HLA-DQ6

DQB1*0601 is generally linked to DQA1*0103 as 6.1 haplotype. This haplotype is more common in Japan and other parts of East Asia.

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DQB1*0602 is commonly linked to DQA1*0102 to form 6.2 haplotype. DQ6.2 and is common from Central Asia into Western Europe, *0602 is also linked to DQA1*0103 in parts of Asia.

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DQB1*0603 is commonly linked to DQA1*0103 as 6.3 and is common from Central Asia into Western Europe, *0603 is also linked to DQA1*0102 in parts of Asia. In Europe it is most common in the Netherlands.

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DQB1*0604 is found at higher frequencies in parts Africa and Asia and is linked almost exclusively to DQA1*0102 as 6.4. This haplotype is found at its highest Eurasian frequencies in Japan.

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DQB1*0609 is found in Africa and proximal regions of Eurasia.

Susceptibility to Leptospirosis infection was found associated with undifferentiated DQ6.{{cite journal |author=Lingappa J |title=HLA-DQ6 and ingestion of contaminated water: possible gene-environment interaction in an outbreak of Leptospirosis |journal=Genes Immun. |volume=5 |issue=3 |pages=197–202 |date=May 2004 |pmid=15014429 |doi=10.1038/sj.gene.6364058 |author2=Kuffner T |author3=Tappero J |last4=Whitworth |first4=W |last5=Mize |first5=A |last6=Kaiser |first6=R |last7=McNicholl |first7=J|s2cid=1771348 |doi-access= }} Whereas DQ6 was protective against death (or need for liver transplantion) in primary sclerosing cholangitis.{{cite journal |author=Boberg KM |title=The HLA-DR3,DQ2 heterozygous genotype is associated with an accelerated progression of primary sclerosing cholangitis |journal=Scand. J. Gastroenterol. |volume=36 |issue=8 |pages=886–890 |date=August 2001 |pmid=11495087 |doi= 10.1080/003655201750313441|author2=Spurkland A |author3=Rocca G |last4=Egeland |first4=T. |last5=Saarinen |first5=S. |last6=Mitchell |first6=S. |last7=Broomé |first7=U. |last8=Chapman |first8=R. |last9=Olerup |first9=O.}}

DQA1*0103:DQB1*0601 (DQ6.1) is found at increased frequencies in Asia and is almost

absent in Western Europe. It confers protection from narcolepsy,{{cite journal | author = Hong SC | title = DQB1*0301 and DQB1*0601 modulate narcolepsy susceptibility in Koreans | journal = Hum. Immunol. | volume = 68 | issue = 1 | pages = 59–68 | year = 2007 | pmid = 17207713 | doi = 10.1016/j.humimm.2006.10.006 | author2 = Lin L | author3 = Lo B | last4 = Jeong | first4 = J | last5 = Shin | first5 = Y | last6 = Kim | first6 = S | last7 = Kweon | first7 = Y | last8 = Zhang | first8 = J | last9 = Einen | first9 = M}} juvenile diabetes,{{cite journal |vauthors=Sang Y, Yan C, Zhu C, Ni G | title = Relationship between HLA-DRB1 and DQ alleles and the genetic susceptibility to type 1 diabetes | journal = Chin. Med. J. | volume = 114 | issue = 4 | pages = 407–9 | year = 2001 | pmid = 11780465 }}{{cite journal | author = Saruhan-Direskeneli G | title = HLA-DR and -DQ associations with insulin-dependent diabetes mellitus in a population of Turkey | journal = Hum. Immunol. | volume = 61 | issue = 3 | pages = 296–302 | year = 2000 | pmid = 10689119 | doi =10.1016/S0198-8859(99)00182-2 | author2 = Uyar FA | author3 = Bas F | last4 = Günöz | first4 = H | last5 = Bundak | first5 = R | last6 = Saka | first6 = N | last7 = Darendeliler | first7 = F }} Vogt-Koyanagi-Harada (VKH) syndrome,{{cite journal | author = Kim MH | title = Association of HLA with Vogt-Koyanagi-Harada syndrome in Koreans | journal = Am. J. Ophthalmol. | volume = 129 | issue = 2 | pages = 173–177 | year = 2000 | pmid = 10682969 | doi =10.1016/S0002-9394(99)00434-1 | author2 = Seong MC | author3 = Kwak NH | last4 = Yoo | first4 = Jin-Seong | last5 = Huh | first5 = Warne | last6 = Kim | first6 = Tai-Gyu | last7 = Han | first7 = Hoon }} pemphigus vulgaris,{{cite journal | author = Niizeki H | title = HLA-DQA1, -DQB1 and -DRB1 genotyping in Japanese pemphigus vulgaris patients by the PCR-RFLP method | journal = Tissue Antigens | volume = 44 | issue = 4 | pages = 248–251 | year = 1994 | pmid = 7871526 | doi =10.1111/j.1399-0039.1994.tb02390.x | author2 = Inoko H | author3 = Mizuki N | last4 = Inamoto | first4 = Nobuko | last5 = Watababe | first5 = Kyoko | last6 = Hashimoto | first6 = Takashi | last7 = Nishikawa | first7 = Takeji }} multiple sclerosis,{{cite journal | author = Amirzargar A | title = HLA class II (DRB1, DQA1 and DQB1) associated genetic susceptibility in Iranian multiple sclerosis (MS) patients | journal = Eur. J. Immunogenet. | volume = 25 | issue = 4 | pages = 297–301 | year = 1998 | pmid = 9777330 | doi =10.1046/j.1365-2370.1998.00101.x | author2 = Mytilineos J | author3 = Yousefipour A | last4 = Farjadian | first4 = Sh. | last5 = Scherer | first5 = S. | last6 = Opelz | first6 = G. | last7 = Ghaderi | first7 = A. | doi-access = free }} myasthenia gravis.

DQ6.2 (DQA1{{color|DarkOrchid|*0102}} : DQB1{{color|DarkGreen|*0602}}) is commonly linked to DR15 and as such is part of the HLA B7-DR15-DQ6 haplotype. This haplotype is considered to be the longest multigene haplotype known within the human genome as it covers over 4.7 million nucleotides. The DR15-DQ6.2 haplotype is the most common DR-DQ haplotype in Europe, and approximately 30% of Americans carry at least DQ6.2. The haplotype is even more common in Central Asia.

For myasthenia gravis, recognition α34-49 of AChR increased with DQ6.2.{{cite journal |vauthors=Deitiker PR, Oshima M, Smith RG, Mosier DR, Atassi MZ | title = Subtle differences in HLA DQ haplotype-associated presentation of AChR alpha-chain peptides may suffice to mediate myasthenia gravis | journal = Autoimmunity | volume = 39 | issue = 4 | pages = 277–288 | year = 2006 | pmid = 16891216 | doi = 10.1080/08916930600738581| s2cid = 23462117 }} DQA1{{color|DarkOrchid|*0102}} increases risk cervical cancer.{{cite journal |author=Ghaderi M |title=Tumor necrosis factor a-11 and DR15-DQ6 (B*0602) haplotype increase the risk for cervical intraepithelial neoplasia in human papillomavirus 16 seropositive women in Northern Sweden |journal=Cancer Epidemiol. Biomarkers Prev. |volume=9 |issue=10 |pages=1067–70 |date=October 2000 |pmid=11045789 |url=http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=11045789 |author2=Nikitina L |author3=Peacock CS |last4=Hjelmström |first4=P |last5=Hallmans |first5=G |last6=Wiklund |first6=F |last7=Lenner |first7=P |last8=Blackwell |first8=JM |last9=Dillner |first9=J}}{{cite journal |vauthors=Schiff MA, Apple RJ, Lin P, Nelson JL, Wheeler CM, Becker TM | title = HLA alleles and risk of cervical intraepithelial neoplasia among southwestern American Indian women | journal = Hum. Immunol. | volume = 66 | issue = 10 | pages = 1050–1056 | year = 2005 | pmid = 16386646 | doi = 10.1016/j.humimm.2005.09.002}} In multiple sclerosis DQA1{{color|DarkOrchid|*0102}} was the most frequent allele and DQB1{{color|DarkGreen|*0602}} increased significantly in the MS patients.{{cite journal |vauthors=Kolstad A, Hannestad K, Vandvik B, Vartdal F |title=Multiple sclerosis patients have a high frequency of an HLA-DQ beta epitope defined by a human-human hybridoma antibody |journal=Tissue Antigens |volume=33 |issue=5 |pages=546–549 |date=May 1989 |pmid=2477915 |doi= 10.1111/j.1399-0039.1989.tb01706.x}}{{cite journal | author = Amirzargar AA | title = Optic neuritis, multiple sclerosis and human leukocyte antigen: results of a 4-year follow-up study | journal = Eur. J. Neurol. | volume = 12 | issue = 1 | pages = 25–30 | year = 2005 | pmid = 15613143 | doi = 10.1111/j.1468-1331.2004.00901.x | author2 = Tabasi A | author3 = Khosravi F | last4 = Kheradvar | first4 = A. | last5 = Rezaei | first5 = N. | last6 = Naroueynejad | first6 = M. | last7 = Ansaripour | first7 = B. | last8 = Moradi | first8 = B. | last9 = Nikbin | first9 = B.| s2cid = 11114806 }}{{cite journal|author=Fernández O|author2=Fernández V|author3=Alonso A|last4=Caballero|first4=A.|last5=Luque|first5=G.|last6=Bravo|first6=M.|last7=León|first7=A.|last8=Mayorga|first8=C.|last9=Leyva|first9=L.|year=2004|title=DQB1*0602 allele shows a strong association with multiple sclerosis in patients in Malaga, Spain|journal=J. Neurol.|volume=251|issue=4|pages=440–444|doi=10.1007/s00415-004-0350-2|pmid=15083289|s2cid=6388921 }}

In primary biliary cirrhosis DQ6.2 appears to have a negative association with disease.{{cite journal | author = Mullarkey ME | title = Human leukocyte antigen class II alleles in Caucasian women with primary biliary cirrhosis | journal = Tissue Antigens | volume = 65 | issue = 2 | pages = 199–205 | year = 2005 | pmid = 15713222 | doi = 10.1111/j.1399-0039.2005.00351.x | author2 = Stevens AM | author3 = McDonnell WM | last4 = Loubiere | first4 = L.S. | last5 = Brackensick | first5 = J.A. | last6 = Pang | first6 = J.M. | last7 = Porter | first7 = A.J. | last8 = Galloway | first8 = D.A. | last9 = Nelson | first9 = J.L.}} DQ6.2 also appears to have a protective effect in juvenile diabetes.{{cite journal |vauthors=Rayner ML, Kelly MA, Mijovic CH, Barnett AH |title=Sequencing of the second exon of the MHC class II DQ6 alleles in patients with type 1 diabetes |journal=Autoimmunity |volume=35 |issue=2 |pages=155–157 |date=March 2002 |pmid=12071438 |doi= 10.1080/08916930290016637|s2cid=46348916 }}{{cite journal |vauthors=Pociot F, McDermott MF |title=Genetics of type 1 diabetes mellitus |journal=Genes Immun. |volume=3 |issue=5 |pages=235–249 |date=August 2002 |pmid=12140742 |doi=10.1038/sj.gene.6363875 |s2cid=19983853 |doi-access= }} DQ6.2 is also protective against infantile spasms in mestizos.{{cite journal |vauthors=Suastegui RA, De La Rosa G, Carranza JM, Gonzalez-Astiazaran A, Gorodezky C |title=Contribution of the MHC class II antigens to the etiology of infantile spasm in Mexican Mestizos |journal=Epilepsia |volume=42 |issue=2 |pages=210–215 |date=February 2001 |pmid=11240591 |doi=10.1046/j.1528-1157.2001.22700.x |doi-access=free }}

DQ6.3 (DQA1{{color|DarkOrchid|*0103}} : DQB1{{color|DarkGreen|*0603}}) is found in northcentral Europe at moderate frequencies, it is a protective against many autoimmune diseases. It also affords some protection to HIV infection.{{cite journal |vauthors=Achord AP, Lewis RE, Brackin MN, Henderson H, Cruse JM |title=HIV-1 disease association with HLA-DQ antigens in African Americans and Caucasians |journal=Pathobiology |volume=64 |issue=4 |pages=204–208 |year=1996 |pmid=9031330 |doi= 10.1159/000164049}}

DQ6.4 (DQA1{{color|DarkOrchid|*0102}} : DQB1{{color|DarkGreen|*0604}}) might be associated with thymoma-induced myasthenia gravis.{{cite journal |vauthors=Vieira M, Caillat-Zucman S, Gajdos P, Cohen-Kaminsky S, Casteur A, Bach J | title = Identification by genomic typing of non-DR3 HLA class II genes associated with myasthenia gravis | journal = J Neuroimmunol | volume = 47 | issue = 2 | pages = 115–122 | year = 1993 | pmid = 8370765 | doi = 10.1016/0165-5728(93)90021-P| s2cid = 3771373 }}

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{{DQ serotypes}}

{{DEFAULTSORT:Hla-Dq6}}

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