HLA-DQ9
{{Infobox heteroisoform
| isoformgroup = HLA-DQ9
| polymer_type = MHC Class II, DQ cell surface antigen
| image = DQ_Illustration.PNG
| image_source = Illustration of HLA-DQ with bound peptide.
| isoformCount = 2
| subunit1 = DQA1
| subunit2 = DQB1
| isoform1 = DQ α2β9
| nick1 = DQ9.2
| allele1a = {{HQAA|0201}}
| allele1b = *0303
| isoform2 = DQ α3β9
| nick2 = DQ9.3
| allele2a = {{HQAA|0302}}
| allele2b = *0303
| rareIsoforms = 0
}}
HLA-DQ9 (DQ9) is a human leukocyte antigen serotype within the HLA-DQ (DQ) serotype group. DQ9 is a split antigen of the DQ3 broad antigen. DQ9 is determined by the antibody recognition of β9 and this generally detects the gene product of DQB1*0303.
Serology
| border="0" cellspacing="0" cellpadding="0" align="left" style="text-align:center; background:#ffffff; margin-right: 2em; border:2px #e0e0ff solid;"
|+ DQ2, DQ3, DQ7, DQ8, and DQ9 recognition of DRB1*0303 product[http://www.ebi.ac.uk/imgt/hla/allele.html derived from IMGT/HLA] | ||||||
| style="background:#f0f0ff"
| style="width:60px" | | style="width:60px" | DQ9
| style="width:60px" | DQ3 | style="width:60px" | {{color|red|DQ2}} | style="width:60px" | {{color|red|DQ7}} | style="width:60px" | {{color|red|DQ8}} | style="width:60px" | sample | |
| style="background:#f0f0ff"
| | % | % | % | % | % | (N) |
| style="background:#e8e8f8" | {{HQBA|0303}} | 67 | 12 | {{color|red|11}} | {{color|red|1}} | {{color|red|1}} | 2563 |
| colspan = 7 style="font-size:smaller" | {{color|red|Red indicates the level of 'false' reaction in non-DQ9 serotypes}} | ||||||
| colspan = 7 style="font-size:smaller" | Alleles link-out to IMGT/HLA Databease at EBI |
The serotyping efficiency of DQ9 is poor. The recognition of DQB1*0303 by DQ9 and or DQ3 is poorest, DQ2 which recognizes a different DQB1 subgroup recognizes DQB1*0303 as efficiently as DQ3. For this reason DQ9 serotyping is a poor method of typing for transplantation or disease association prediction or study.
DQB1*0303
(DQ9) is associated with nasal polyps,{{cite journal |vauthors=Zhai L, Sun Y, Tang L, Liu H | s2cid = 31676125 | title = Polymorphism between loci for human leukocyte antigens DR and DQ in patients with nasal polyps | journal = Ann. Otol. Rhinol. Laryngol. | volume = 116 | issue = 1 | pages = 66–8 | year = 2007 | pmid = 17305280 | doi = 10.1177/000348940711600111}} gestational diabetes,{{cite journal |vauthors=Törn C, Gupta M, Sanjeevi CB, Aberg A, Frid A, Landin-Olsson M | title = Different HLA-DR-DQ and MHC class I chain-related gene A (MICA) genotypes in autoimmune and nonautoimmune gestational diabetes in a Swedish population | journal = Hum. Immunol. | volume = 65 | issue = 12 | pages = 1443–50 | year = 2004 | pmid = 15603871 | doi = 10.1016/j.humimm.2004.09.002}} microscopic polyangiitis (Japanese). Primary linkage is with DRB1*0901-DQB1*0303 {{cite journal |vauthors=Tsuchiya N, Kobayashi S, Hashimoto H, Ozaki S, Tokunaga K | title = Association of HLA-DRB1*0901-DQB1*0303 haplotype with microscopic polyangiitis in Japanese | journal = Genes Immun. | volume = 7 | issue = 1 | pages = 81–4 | year = 2006 | pmid = 16208405 | doi = 10.1038/sj.gene.6364262 | s2cid = 44812261 | doi-access = }}
Haplotypes and disease
=DQ9.2=
DQA1*0201:DQB1*0303 is associated with type I psoriasis (vulgaris),{{cite journal |vauthors=Schmitt-Egenolf M, Boehncke WH, Ständer M, Eiermann TH, Sterry W | title = Oligonucleotide typing reveals association of type I psoriasis with the HLA-DRB1*0701/2, -DQA1*0201, -DQB1*0303 extended haplotype | journal = J. Invest. Dermatol. | volume = 100 | issue = 6 | pages = 749–52 | year = 1993 | pmid = 8496614 | doi =10.1111/1523-1747.ep12476080 | doi-access = }}{{cite journal |vauthors=Zhang X, Wei S, Yang S, etal | title = HLA-DQA1 and DQB1 alleles are associated with genetic susceptibility to psoriasis vulgaris in Chinese Han | journal = Int. J. Dermatol. | volume = 43 | issue = 3 | pages = 181–7 | year = 2004 | pmid = 15009387 | doi =10.1111/j.1365-4632.2004.02098.x | s2cid = 36893870 }}
=DQ9.3=
DQA1*0302:DQB1*0303 maybe associated with juvenile diabetes in the orient.{{cite journal |vauthors=Maruyama T, Shimada A, Kasuga A, etal | title = Analysis of MHC class II antigens in Japanese IDDM by a novel HLA-typing method, hybridization protection assay | journal = Diabetes Res. Clin. Pract. | volume = 23 | issue = 2 | pages = 77–84 | year = 1994 | pmid = 8070305 | doi =10.1016/0168-8227(94)90014-0 }}{{cite journal |vauthors=Ikegami H, Kawaguchi Y, Yamato E, etal | title = Analysis by the polymerase chain reaction of histocompatibility leucocyte antigen-DR9-linked susceptibility to insulin-dependent diabetes mellitus | journal = J. Clin. Endocrinol. Metab. | volume = 75 | issue = 5 | pages = 1381–5 | year = 1992 | doi = 10.1210/jcem.75.5.1358911 | pmid = 1358911 }}
(Chinese) Primary linkage of vitiligo is with DQA1*03-DQB1*0303.{{cite journal |vauthors=Xia Q, Zhou WM, Liang YH, etal | title = MHC haplotypic association in Chinese Han patients with vitiligo | journal = Journal of the European Academy of Dermatology and Venereology | volume = 20 | issue = 8 | pages = 941–6 | year = 2006 | pmid = 16922942 | doi = 10.1111/j.1468-3083.2006.01686.x| s2cid = 12831704 }}