HLA-DR1

The serology for the most common DR1 alleles is excellent. The serology for alleles {{HDR1A|01:04}}, {{HDR1A|01:06}}, {{HDR1A|01:09}}, {{HDR1A|01:10}}, {{HDR1A|0112}}, {{HDR1A|0115}}, and {{HDR1A|0116}} is unknown.

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DR1 is associated with seronegative{{cite journal |vauthors=Bardin T, Legrand L, Naveau B, Marcelli-Barge A, Debeyre N, Lathrop G, Poirier J, Schmid M, Ryckewaert A, Dryll A | title = HLA antigens and seronegative rheumatoid arthritis | journal = Ann Rheum Dis | volume = 44 | issue = 1 | pages = 50–53 | year = 1985 | pmid = 3855618 | doi = 10.1136/ard.44.1.50 | pmc = 1001567}}-rheumatoid arthritis,{{cite journal |vauthors=Schiff B, Mizrachi Y, Orgad S, Yaron M, Gazit E | title = Association of HLA-Aw31 and HLA-DR1 with adult rheumatoid arthritis | journal = Ann Rheum Dis | volume = 41 | issue = 4 | pages = 403–404 | year = 1982 | pmid = 6981387 | doi = 10.1136/ard.41.4.403 | pmc = 1000958}}{{cite journal | title = HLA-DR antigens in rheumatoid arthritis. A Swiss collaborative study; final report. Swiss Federal Commission for the Rheumatic Diseases, Subcommission for Research | journal = Rheumatol Int | volume = 6 | issue = 2 | pages = 89–92 | year = 1986 | pmid = 3489975 | doi=10.1007/bf00541511| s2cid = 189901283 }} penicillamine-induced myasthenia,{{cite journal |vauthors=Delamere J, Jobson S, Mackintosh L, Wells L, Walton K | title = Penicillamine-induced myasthenia in rheumatoid arthritis: its clinical and genetic features | journal = Ann Rheum Dis | volume = 42 | issue = 5 | pages = 500–504 | year = 1983 | pmid = 6605118 | doi = 10.1136/ard.42.5.500 | pmc = 1001283}} and schizophrenia.{{cite journal |vauthors=Narita K, Sasaki T, Akaho R, Okazaki Y, Kusumi I, Kato T, Hashimoto O, Fukuda R, Koyama T, Matsuo K, Okabe Y, Nanko S, Hohjoh H, Tokunaga K | title = Human leukocyte antigen and season of birth in Japanese patients with schizophrenia | journal = Am J Psychiatry | volume = 157 | issue = 7 | pages = 1173–1175 | year = 2000 | pmid = 10873932 | doi = 10.1176/appi.ajp.157.7.1173}} DR1 is increased in patients with systemic sclerosis and arthritis{{cite journal | author = Szücs G | title = Systemic sclerosis-rheumatoid arthritis overlap syndrome: a unique combination of features suggests a distinct genetic, serological and clinical entity | journal = Rheumatology | volume = 46 | issue = 6 | pages = 989–993 | year = 2007 | pmid = 17384178 | doi = 10.1093/rheumatology/kem021 |name-list-style=vanc| author2 = Szekanecz Z | author3 = Zilahi E | display-authors = 3 | last4 = Kapitany | first4 = A. | last5 = Barath | first5 = S. | last6 = Szamosi | first6 = S. | last7 = Vegvari | first7 = A. | last8 = Szabo | first8 = Z. | last9 = Szanto | first9 = S.| doi-access = free }} and in ulcerative colitis with patients that have articular manifestations.{{cite journal | author = Núñez C | title = Genetic markers linked to rheumatoid arthritis are also strongly associated with articular manifestations in ulcerative colitis patients | journal = Hum. Immunol. | volume = 67 | issue = 4–5 | pages = 324–330 | year = 2006 | pmid = 16720213 | doi = 10.1016/j.humimm.2006.02.035 |name-list-style=vanc| author2 = Alecsandru DM | author3 = Mendoza JL | display-authors = 3 | last4 = Urcelay | first4 = E | last5 = Diazrubio | first5 = M | last6 = Delaconcha | first6 = E | last7 = Martinez | first7 = A}}

DRB1*01:01 is associated with rheumatoid arthritis,{{cite journal | author = Kapitány A | title = Association of rheumatoid arthritis with HLA-DR1 and HLA-DR4 in Hungary | journal = Ann. N. Y. Acad. Sci. | volume = 1051 | issue = 1| pages = 263–270 | year = 2005 | pmid = 16126967 | doi = 10.1196/annals.1361.067 |name-list-style=vanc| author2 = Zilahi E | author3 = Szántó S | display-authors = 3 | last4 = Szücs | first4 = Gabriella | last5 = Szabó | first5 = Zoltán | last6 = Végvári | first6 = Anikó | last7 = Rass | first7 = Péter | last8 = Sipka | first8 = Sándor | last9 = Szegedi | first9 = Gyula| bibcode = 2005NYASA1051..263K | s2cid = 6515443 }} in anti-Jk(a) mediated hemolytic transfusion reactions,{{cite journal | author = Reviron D | title = HLA-DRB1 alleles and Jk(a) immunization | journal = Transfusion | volume = 45 | issue = 6 | pages = 956–959 | year = 2005 | pmid = 15934994 | doi = 10.1111/j.1537-2995.2005.04366.x |name-list-style=vanc| author2 = Dettori I | author3 = Ferrera V | display-authors = 3 | last4 = Legrand | first4 = Dominique | last5 = Touinssi | first5 = Mhammed | last6 = Mercier | first6 = Pierre | last7 = De Micco | first7 = Philippe | last8 = Chiaroni | first8 = Jacques| s2cid = 20473677 | doi-access = free }} foliaceous pemphigus,{{cite journal |vauthors=del Mar Sáez-de-Ocariz M, Vega-Memije M, Zúñiga J, Salgado N, Ruíz J, Balbuena A, Domínguez-Soto L, Granados J | title = HLA-DRB1*0101 is associated with foliaceous pemphigus in Mexicans | journal = Int J Dermatol | volume = 44 | issue = 4 | pages = 350 | year = 2005 | pmid = 15811100 | doi = 10.1111/j.1365-4632.2005.02038.x| s2cid = 21880556 }} HTLV-1-associated myelopathy/tropical spastic paraparesis, and {{cite journal |vauthors=Sabouri A, Saito M, Usuku K, Bajestan S, Mahmoudi M, Forughipour M, Sabouri Z, Abbaspour Z, Goharjoo M, Khayami E, Hasani A, Izumo S, Arimura K, Farid R, Osame M | title = Differences in viral and host genetic risk factors for development of human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis between Iranian and Japanese HTLV-1-infected individuals | journal = J Gen Virol | volume = 86 | issue = Pt 3 | pages = 773–781 | year = 2005 | pmid = 15722539 | doi = 10.1099/vir.0.80509-0| doi-access = free }} lichen planus.{{cite journal |author=Luis-Montoya P |title=HLA-DRB1*0101 is associated with the genetic susceptibility to develop lichen planus in the Mexican Mestizo population |journal= Archives of Dermatological Research|volume= 299|issue= 8|pages= 405–407|year=2007 |pmid=17665209 |doi=10.1007/s00403-007-0769-2 |name-list-style=vanc|author2=Yamamoto-Furusho JK |author3=Vega-Memije E |display-authors=3 |last4=Rodríguez-Carreón |first4=A. |last5=Ruiz-Morales |first5=J. A. |last6=Vargas-Alarcón |first6=G. |last7=Domínguez-Soto |first7=L. |last8=Granados |first8=J.|s2cid=5986703 }} In lyme disease arthritis, *01:01 appears to play a role in

presentation of triggering microbial antigens.{{cite journal |author=Steere AC |title=Antibiotic-refractory Lyme arthritis is associated with HLA-DR molecules that bind a Borrelia burgdorferi peptide |journal=J. Exp. Med. |volume=203 |issue=4 |pages=961–971 |year=2006 |pmid=16585267 |doi=10.1084/jem.20052471 |name-list-style=vanc|author2=Klitz W |author3=Drouin EE |display-authors=3 |last4=Falk |first4=BA |last5=Kwok |first5=WW |last6=Nepom |first6=GT |last7=Baxter-Lowe |first7=LA |pmc=3212725}}

DRB1*01:02 is associated with rheumatoid arthritis, in anti-Jk(a) mediated hemolytic transfusion reactions, psoriasis vulgaris,{{cite journal |vauthors=Cardoso C, Uthida-Tanaka A, Magalhães R, Magna L, Kraemer M | title = Association between psoriasis vulgaris and MHC-DRB, -DQB genes as a contribution to disease diagnosis | journal = Eur J Dermatol | volume = 15 | issue = 3 | pages = 159–63 | year = 2005| pmid = 15908298}} and recurrent respiratory papillomatosis{{cite journal |vauthors=Bonagura V, Vambutas A, DeVoti J, Rosenthal D, Steinberg B, Abramson A, Shikowitz M, Gjertson D, Reed E | title = HLA alleles, IFN-gamma responses to HPV-11 E6, and disease severity in patients with recurrent respiratory papillomatosis | journal = Hum Immunol | volume = 65 | issue = 8 | pages = 773–782 | year = 2004 | pmid = 15336778 | doi = 10.1016/j.humimm.2004.05.014}}

DRB1*01:03 is associated with colonic Crohn's disease{{cite journal |vauthors=Fernandez L, Mendoza J, Martinez A, Urcelay E, Fernandez-Arquero M, Garcia-Paredes J, Peña A, Diaz-Rubio M, de la Concha E | title = IBD1 and IBD3 determine location of Crohn's disease in the Spanish population | journal = Inflamm Bowel Dis | volume = 10 | issue = 6 | pages = 715–722 | year = 2004 | pmid = 15626888 | doi = 10.1097/00054725-200411000-00004| s2cid = 23790673 | doi-access = free }} and ulcerative colitis.{{cite journal |vauthors=Puzanowska B, Prokopowicz D, Ziarko S, Radziwon P, Lapinski T | title = The incidence of HLA DRB1*0103 in ulcerative colitis patients in north-eastern Poland | journal = Hepatogastroenterology | volume = 50 | issue = 53 | pages = 1436–8 | year = 2003| pmid = 14571756}}{{cite journal |vauthors=Roussomoustakaki M, Satsangi J, Welsh K, Louis E, Fanning G, Targan S, Landers C, Jewell D | title = Genetic markers may predict disease behavior in patients with ulcerative colitis | journal = Gastroenterology | volume = 112 | issue = 6 | pages = 1845–1853 | year = 1997 | pmid = 9178675 | doi = 10.1053/gast.1997.v112.pm9178675| doi-access = free }}

DRB1*01:01/*0404 and *01:01/*0401 increases risk of mortality in rheumatoid arthritis, with ischemic heart disease and smoking.{{cite journal |author=Mattey DL |title=Association of DRB1 shared epitope genotypes with early mortality in rheumatoid arthritis: results of eighteen years of followup from the early rheumatoid arthritis study |journal=Arthritis Rheum. |volume=56 |issue=5 |pages=1408–1416 |year=2007 |pmid=17469097 |doi=10.1002/art.22527 |name-list-style=vanc|author2=Thomson W |author3=Ollier WE |display-authors=3 |last4=Batley |first4=M. |last5=Davies |first5=P. G. |last6=Gough |first6=A. K. |last7=Devlin |first7=J. |last8=Prouse |first8=P. |last9=James |first9=D. W.}} these same genotypes are associated with rheumatoid vasculitis.{{cite journal |vauthors=Gorman JD, David-Vaudey E, Pai M, Lum RF, Criswell LA |title=Particular HLA-DRB1 shared epitope genotypes are strongly associated with rheumatoid vasculitis |journal=Arthritis Rheum. |volume=50 |issue=11 |pages=3476–3484 |year=2004 |pmid=15529352 |doi=10.1002/art.20588}}

Image:DR beta 1 SEI topdown.JPG

DRB1*01:02:DQB1*05:01 is associated with psoriasis vulgaris and tubulointerstitial nephritis & uveitis syndrome,{{cite journal |vauthors=Levinson R, Park M, Rikkers S, Reed E, Smith J, Martin T, Rosenbaum J, Foster C, Sherman M, Holland G | title = Strong associations between specific HLA-DQ and HLA-DR alleles and the tubulointerstitial nephritis and uveitis syndrome | journal = Invest Ophthalmol Vis Sci | volume = 44 | issue = 2 | pages = 653–657 | year = 2003 | pmid = 12556395 | doi = 10.1167/iovs.02-0376| doi-access = }} but is relatively protective against juvenile diabetes.{{cite journal | author = Thomson G | title = Relative predispositional effects of HLA class II DRB1-DQB1 haplotypes and genotypes on type 1 diabetes: a meta-analysis | journal = Tissue Antigens | volume = 70 | issue = 2 | pages = 110–127 | year = 2007 | pmid = 17610416 | doi = 10.1111/j.1399-0039.2007.00867.x |name-list-style=vanc| author2 = Valdes AM | author3 = Noble JA | display-authors = 3 | last4 = Kockum | first4 = I. | last5 = Grote | first5 = M. N. | last6 = Najman | first6 = J. | last7 = Erlich | first7 = H. A. | last8 = Cucca | first8 = F. | last9 = Pugliese | first9 = A.| doi-access = free }}

DR1-DQ5 is associated with tubulointerstitial nephritis & uveitis syndrome.

{{HLA haplotypes}}

{{Clarify|text=DR1 are associated with rheumatoid arthritis, and while not the strongest association with the highest risk for early onset arthritis is within the DR4-bearing Native American population.|date=March 2023}} There frequency of DR4-DQ8 haplotypes reach extreme nodal levels. Arthritis has been identified in a pre-Columbian remains from Italy, the affected individual bearing the DRB1*01:01 allele.{{cite journal |author=Fontecchio G |title=Genetic predisposition to rheumatoid arthritis in a Tuscan (Italy) ancient human remain |journal=International Journal of Immunopathology and Pharmacology |volume=20 |issue=1 |pages=103–9 |year=2007 |pmid=17346433 |doi= 10.1177/039463200702000112|name-list-style=vanc|author2=Fioroni MA |author3=Azzarone R |display-authors=3 |last4=Battistoni |first4=C |last5=Cervelli |first5=C |last6=Ventura |first6=L |last7=Mercurio |first7=C |last8=Fornaciari |first8=G |last9=Papola |first9=F|s2cid=2067413 |doi-access=free }} DRB1*01:01 and most DR4 have in common a 'shared epitope'.{{cite journal |vauthors=Gregersen PK, Silver J, Winchester RJ |title=The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis |journal=Arthritis Rheum. |volume=30 |issue=11 |pages=1205–1213 |year=1987 |pmid=2446635 |doi= 10.1002/art.1780301102|doi-access=free }}{{cite journal |vauthors=Morel PA, Erlich HA, Fathman CG |title=A new look at the shared epitope hypothesis |journal=Am. J. Med. |volume=85 |issue=6A |pages=20–22 |year=1988 |pmid=2462347 |doi= 10.1016/0002-9343(88)90375-0}} In this hypothesis a common region of the beta chain, positions 67 to 74, are common and may be integral to presenting auto-immunological peptides.

HLA-DR1 is not genetically linked to DR51, DR52 or DR53, but is linked to HLA-DQ1 and DQ5 serotypes.

{{reflist}}

{{DR serotypes}}

{{DEFAULTSORT:Hla-Dr1}}

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