HLA-DR17

DR17 recognizes the DRB1*0301, *0304 alleles.

DR17 is associated with non-chronic sarcoidosis,{{cite journal |vauthors=Berlin M, Fogdell-Hahn A, Olerup O, Eklund A, Grunewald J | title = HLA-DR predicts the prognosis in Scandinavian patients with pulmonary sarcoidosis. | journal = Am J Respir Crit Care Med | volume = 156 | issue = 5 | pages = 1601–5 | year = 1997 | pmid = 9372682 | doi=10.1164/ajrccm.156.5.9704069}}{{cite journal |vauthors=Planck A, Katchar K, Eklund A, Gripenbäck S, Grunewald J | title = T-lymphocyte activity in HLA-DR17 positive patients with active and clinically recovered sarcoidosis. | journal = Sarcoidosis Vasc Diffuse Lung Dis | volume = 20 | issue = 2 | pages = 110–7 | year = 2003 | pmid = 12870720}} infantile spasm/epilepsy,{{cite journal |vauthors=Suastegui R, De La Rosa G, Carranza J, Gonzalez-Astiazaran A, Gorodezky C | title = Contribution of the MHC class II antigens to the etiology of infantile spasm in Mexican Mestizos. | journal = Epilepsia | volume = 42 | issue = 2 | pages = 210–5 | year = 2001 | pmid = 11240591 | doi = 10.1046/j.1528-1157.2001.22700.x| doi-access = free }} rabies vaccine-induced autoimmune encephalomyelitis{{cite journal |vauthors=Piyasirisilp S, Schmeckpeper B, Chandanayingyong D, Hemachudha T, Griffin D | title = Association of HLA and T-cell receptor gene polymorphisms with Semple rabies vaccine-induced autoimmune encephalomyelitis. | journal = Ann Neurol | volume = 45 | issue = 5 | pages = 595–600 | year = 1999 | pmid = 10319881 | doi = 10.1002/1531-8249(199905)45:5<595::AID-ANA7>3.0.CO;2-M| s2cid = 28870098 }} and cardiovascular hypertrophy in subjects with arterial hypertension{{cite journal |vauthors=Diamantopoulos E, Andreadis E, Vassilopoulos C, Vlachonikolis I, Tarassi K, Chatzis N, Giannakopoulos N, Papasteriades C | title = Association of specific HLA phenotypes with left ventricular mass and carotid intima-media thickness in hypertensives. | journal = Am J Hypertens | volume = 14 | issue = 7 Pt 1 | pages = 632–6 | year = 2001 | pmid = 11465646 | doi = 10.1016/S0895-7061(01)01283-3| doi-access = free }} People with DR17 show a tendency toward benzylpenicilloyl allergies.{{cite journal |vauthors=Yang J, Qiao HL, Zhang YW, Jia LJ, Tian X, Gao N | title = HLA-DRB genotype and specific IgE responses in patients with allergies to penicillins | journal = Chin. Med. J. | volume = 119 | issue = 6 | pages = 458–66 | year = 2006 | pmid = 16584643 | doi = 10.1097/00029330-200603020-00005| doi-access = free }}

DRB1*0301: diabetes mellitus type 1,{{cite journal |vauthors=Shawkatova I, Michalkova D, Barak L, Fazekasova H, Kuba D, Buc M | title = HLA class II allele frequencies in type 1A diabetes mellitus Slovak patients. | journal = Bratisl Lek Listy | volume = 107 | issue = 3 | pages = 76–9 | year = 2006 | pmid = 16796128}} myositis,{{cite journal |vauthors=O'Hanlon T, Carrick D, Targoff I, Arnett F, Reveille J, Carrington M, Gao X, Oddis C, Morel P, Malley J, Malley K, Shamim E, Rider L, Chanock S, Foster C, Bunch T, Blackshear P, Plotz P, Love L, Miller F | title = Immunogenetic risk and protective factors for the idiopathic inflammatory myopathies: distinct HLA-A, -B, -Cw, -DRB1, and -DQA1 allelic profiles distinguish European American patients with different myositis autoantibodies. | journal = Medicine (Baltimore) | volume = 85 | issue = 2 | pages = 111–27 | year = 2006 | pmid = 16609350 | doi = 10.1097/01.md.0000217525.82287.eb| s2cid = 25224623 | url = https://zenodo.org/record/1234859 }} early onset Graves disease,{{cite journal |vauthors=Lavard L, Madsen H, Perrild H, Jacobsen B, Svejgaard A | title = HLA class II associations in juvenile Graves' disease: indication of a strong protective role of the DRB1*0701,DQA1*0201 haplotype. | journal = Tissue Antigens | volume = 50 | issue = 6 | pages = 639–41 | year = 1997 | pmid = 9458117 | doi = 10.1111/j.1399-0039.1997.tb02922.x}} type 1 autoimmune hepatitis,{{cite journal |vauthors=Czaja A, Strettell M, Thomson L, Santrach P, Moore S, Donaldson P, Williams R | title = Associations between alleles of the major histocompatibility complex and type 1 autoimmune hepatitis. | journal = Hepatology | volume = 25 | issue = 2 | pages = 317–23 | year = 1997 | pmid = 9021941 | doi = 10.1002/hep.510250211| s2cid = 42248704 | doi-access = }} inflammatory inclusion body myositis.{{cite journal |vauthors=Sivakumar K, Semino-Mora C, Dalakas M | title = An inflammatory, familial, inclusion body myositis with autoimmune features and a phenotype identical to sporadic inclusion body myositis. Studies in three families | journal = Brain | volume = 120 | issue = 4| pages = 653–61 | year = 1997| pmid = 9153127 | doi=10.1093/brain/120.4.653| doi-access = }} In autoimmune hepatitis,

DRB1*0301 correlates with more severe and difficult to treat disease.{{cite journal |vauthors=Montano Loza AJ, Czaja AJ | title = Current therapy for autoimmune hepatitis | journal = Nature Clinical Practice Gastroenterology & Hepatology | volume = 4 | issue = 4 | pages = 202–14 | year = 2007 | pmid = 17404588 | doi = 10.1038/ncpgasthep0768| s2cid = 24280843 }}

DRB1*0301:DQA1*05:DQB1*0201 is associated with diabetes mellitus type 1,{{cite journal |vauthors=Deja G, Jarosz-Chobot P, Polańska J, Siekiera U, Małecka-Tendera E | title = Is the Association Between TNF-α-308 A Allele and DMT1 Independent of HLA-DRB1, DQB1 Alleles? | journal = Mediators Inflamm | volume = 2006 | issue = 4 | pages = 1–7 | year = 2006 | pmid = 17047287 | doi = 10.1155/MI/2006/19724 | pmc = 1618952| doi-access = free }} ovarian cancer,{{cite journal |vauthors=Kübler K, Arndt P, Wardelmann E, Krebs D, Kuhn W, van der Ven K | title = HLA-class II haplotype associations with ovarian cancer | journal = Int J Cancer | volume = 119 | issue = 12 | pages = 2980–5 | year = 2006 | pmid = 17016821 | doi = 10.1002/ijc.22266| doi-access = free }} non-thymomic myasthenia gravis,{{cite journal |vauthors=Machens A, Löliger C, Pichlmeier U, Emskötter T, Busch C, Izbicki J | title = Correlation of thymic pathology with HLA in myasthenia gravis | journal = Clinical Immunology | volume = 91 | issue = 3 | pages = 296–301 | year = 1999 | pmid = 10370374 | doi = 10.1006/clim.1999.4710}} idiopathic inflammatory myopathies,{{cite journal |vauthors=Shamim E, Rider L, Miller F | title = Update on the genetics of the idiopathic inflammatory myopathies | journal = Curr Opin Rheumatol | volume = 12 | issue = 6 | pages = 482–91 | year = 2000 | pmid = 11092196 | doi = 10.1097/00002281-200011000-00002| url = https://zenodo.org/record/1234776 }} non-cancer associated Lambert-Eaton myasthenic syndrome{{cite journal |vauthors=Parsons K, Kwok W, Gaur L, Nepom G | title = Increased frequency of HLA class II alleles DRB1*0301 and DQB1*0201 in Lambert-Eaton myasthenic syndrome without associated cancer | journal = Hum Immunol | volume = 61 | issue = 8 | pages = 828–33 | year = 2000 | pmid = 10980394 | doi = 10.1016/S0198-8859(00)00135-X}} and sarcoidosis {{cite journal |vauthors=Grubić R, Žunec T, Peroš-Golubičić J, etal | title = HLA class I and class II frequencies in patients with sarcoidosis from Croatia: role of HLA-B8, −DRB1*0301, and −DQB1*0201 haplotype in clinical variations of the disease | journal = Tissue Antigens | volume = 70 | issue = 4 | pages = 301–6 | year = 2007 | doi = 10.1111/j.1399-0039.2007.00904.x | pmid = 17767551}}

The DRB1*0301/DRB1*1501 heterozygote is linked to primary Sjögren's syndrome{{cite journal |vauthors=Jean S, Quelvennec E, Alizadeh M, Guggenbuhl P, Birebent B, Perdriger A, Grosbois B, Pawlotsky P, Semana G | title = DRB1*15 and DRB1*03 extended haplotype interaction in primary Sjögren's syndrome genetic susceptibility | journal = Clin Exp Rheumatol | volume = 16 | issue = 6 | pages = 725–8 | year = 1998| pmid = 9844767}}

HLA-DR17 is genetically linked to DR52 and HLA-DQ2 serotypes. These serotypes

are the result of gene products from the HLA-DRB3* and HLA DQA1*0501 and HLA DQB1*0201 alleles.

DRB1*0301 is frequently within by the "Super-B8" or ancestral HLA haplotype:

A*0101 : Cw*0701 : B*0801 : DRB1*0301 : DQA1*0501 : DQB1*0201

This haplotype is known as "Super B8", "European ancestral haplotype", or "AH8.1"

{{reflist}}

{{DR serotypes}}

{{DEFAULTSORT:Hla-Dr17}}

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