HMOX2

Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 (this enzyme) belong to the heme oxygenase family.{{cite web | title = Entrez Gene: HMOX2 heme oxygenase (decycling) 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3163}}

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• {{cite journal | vauthors = Bianchetti CM, Yi L, Ragsdale SW, Phillips GN | title = Comparison of Apo- and Heme-bound Crystal Structures of a Truncated Human Heme Oxygenase-2 | journal = J Biol Chem | volume = 282 | issue = 52 | pages = 37624–31 | year = 2007 | pmid = 17965015 | pmc = 2896506 | doi = 10.1074/jbc.M707396200 | doi-access = free }}
• {{cite journal | vauthors = Wang J, Zhuang H, Doré S | title = Heme oxygenase 2 is neuroprotective against intracerebral hemorrhage. | journal = Neurobiol. Dis. | volume = 22 | issue = 3 | pages = 473–6 | year = 2006 | pmid = 16459095 | doi = 10.1016/j.nbd.2005.12.009 | s2cid = 43195015 }}
• {{cite journal | vauthors = Wang J, Doré S | title = Heme oxygenase 2 deficiency increases brain swelling and inflammation after intracerebral hemorrhage | journal = Neuroscience | volume = 155 | issue = 4 | pages = 1133–41 | year = 2008 | pmid = 18674596 | pmc = 4696610 | doi = 10.1016/j.neuroscience.2008.07.004 }}
• {{cite journal | vauthors = Barañano DE, Snyder SH | title = Neural roles for heme oxygenase: Contrasts to nitric oxide synthase | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 20 | pages = 10996–1002 | year = 2001 | pmid = 11572959 | pmc = 58673 | doi = 10.1073/pnas.191351298 | bibcode = 2001PNAS...9810996B | doi-access = free }}
• {{cite journal | vauthors = Doré S | title = Decreased activity of the antioxidant heme oxygenase enzyme: implications in ischemia and in Alzheimer's disease | journal = Free Radic. Biol. Med. | volume = 32 | issue = 12 | pages = 1276–82 | year = 2002 | pmid = 12057765 | doi = 10.1016/S0891-5849(02)00805-5 }}
• {{cite journal | vauthors = Kemp PJ | title = Hemeoxygenase-2 as an O2 sensor in K+ channel-dependent chemotransduction | journal = Biochem. Biophys. Res. Commun. | volume = 338 | issue = 1 | pages = 648–52 | year = 2005 | pmid = 16137652 | doi = 10.1016/j.bbrc.2005.08.110 }}
• {{cite journal | vauthors = Ishikawa K, Takeuchi N, Takahashi S, Matera KM, Sato M, Shibahara S, Rousseau DL, Ikeda-Saito M, Yoshida T | title = Heme oxygenase-2. Properties of the heme complex of the purified tryptic fragment of recombinant human heme oxygenase-2 | journal = J. Biol. Chem. | volume = 270 | issue = 11 | pages = 6345–50 | year = 1995 | pmid = 7890772 | doi = 10.1074/jbc.270.11.6345 | doi-access = free }}
• {{cite journal | vauthors = Kutty RK, Kutty G, Rodriguez IR, Chader GJ, Wiggert B | title = Chromosomal localization of the human heme oxygenase genes: heme oxygenase-1 (HMOX1) maps to chromosome 22q12 and heme oxygenase-2 (HMOX2) maps to chromosome 16p13.3 | journal = Genomics | volume = 20 | issue = 3 | pages = 513–6 | year = 1994 | pmid = 8034330 | doi = 10.1006/geno.1994.1213 | url = https://zenodo.org/record/1229632 }}
• {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
• {{cite journal | vauthors = Takahashi K, Hara E, Suzuki H, Sasano H, Shibahara S | title = Expression of heme oxygenase isozyme mRNAs in the human brain and induction of heme oxygenase-1 by nitric oxide donors | journal = J. Neurochem. | volume = 67 | issue = 2 | pages = 482–9 | year = 1996 | pmid = 8764571 | doi = 10.1046/j.1471-4159.1996.67020482.x | s2cid = 12552519 }}
• {{cite journal | vauthors = Saito-Ohara F, Ikeuchi T, Matsumoto M, Kurata S | title = Assignment of the mouse heme oxygenase genes: heme oxygenase-1 (Hmox1) to chromosome 10 band C1 and heme oxygenase-2 (Hmox2) to chromosome 16 band B1 | journal = Cytogenet. Cell Genet. | volume = 77 | issue = 3–4 | pages = 180–1 | year = 1997 | pmid = 9284910 | doi = 10.1159/000134570 }}
• {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
• {{cite journal | vauthors = Yoshiki N, Kubota T, Aso T | title = Expression and localization of heme oxygenase in human placental villi | journal = Biochem. Biophys. Res. Commun. | volume = 276 | issue = 3 | pages = 1136–42 | year = 2000 | pmid = 11027601 | doi = 10.1006/bbrc.2000.3551 }}
• {{cite journal | vauthors = Hanselmann C, Mauch C, Werner S | title = Haem oxygenase-1: a novel player in cutaneous wound repair and psoriasis? | journal = Biochem. J. | volume = 353 | issue = Pt 3 | pages = 459–66 | year = 2001 | pmid = 11171041 | pmc = 1221590 | doi = 10.1042/0264-6021:3530459 }}
• {{cite journal | vauthors = Appleton SD, Marks GS, Nakatsu K, Brien JF, Smith GN, Graham CH, Lash GE | title = Effects of hypoxia on heme oxygenase expression in human chorionic villi explants and immortalized trophoblast cells | journal = Am. J. Physiol. Heart Circ. Physiol. | volume = 284 | issue = 3 | pages = H853–8 | year = 2003 | pmid = 12578814 | doi = 10.1152/ajpheart.00655.2002 }}
• {{cite journal | vauthors = Galey D, Becker K, Haughey N, Kalehua A, Taub D, Woodward J, Mattson MP, Nath A | title = Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes | journal = J. Neurovirol. | volume = 9 | issue = 3 | pages = 358–71 | year = 2003 | pmid = 12775419 | doi = 10.1080/13550280390201119 | s2cid = 22016092 }}
• {{cite journal | vauthors = Zenclussen AC, Lim E, Knoeller S, Knackstedt M, Hertwig K, Hagen E, Klapp BF, Arck PC | title = Heme oxygenases in pregnancy II: HO-2 is downregulated in human pathologic pregnancies | journal = Am. J. Reprod. Immunol. | volume = 50 | issue = 1 | pages = 66–76 | year = 2004 | pmid = 14506930 | doi = 10.1034/j.1600-0897.2003.00047.x | s2cid = 35763984 }}
• {{cite journal | vauthors = Boehning D, Moon C, Sharma S, Hurt KJ, Hester LD, Ronnett GV, Shugar D, Snyder SH | title = Carbon monoxide neurotransmission activated by CK2 phosphorylation of heme oxygenase-2 | journal = Neuron | volume = 40 | issue = 1 | pages = 129–37 | year = 2003 | pmid = 14527438 | doi = 10.1016/S0896-6273(03)00596-8 | s2cid = 11562548 | doi-access = free }}
• {{cite journal | vauthors = Appleton SD, Lash GE, Marks GS, Nakatsu K, Brien JF, Smith GN, Graham CH | title = Effect of glucose and oxygen deprivation on heme oxygenase expression in human chorionic villi explants and immortalized trophoblast cells | journal = Am. J. Physiol. Regul. Integr. Comp. Physiol. | volume = 285 | issue = 6 | pages = R1453–60 | year = 2004 | pmid = 14615405 | doi = 10.1152/ajpregu.00234.2003 }}

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