HOOK2
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Protein Hook homolog 2 (HK2) is a protein{{cite journal |vauthors=Krämer H, Phistry M | title = Genetic analysis of hook, a gene required for endocytic trafficking in drosophila | journal = Genetics | volume = 151 | issue = 2 | pages = 675–84 |date=February 1999 | doi = 10.1093/genetics/151.2.675 | pmid = 9927460 | pmc = 1460498 }} that in humans is encoded by the HOOK2 gene.{{cite journal |vauthors=Walenta JH, Didier AJ, Liu X, Krämer H | title = The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins | journal = J. Cell Biol. | volume = 152 | issue = 5 | pages = 923–34 |date=March 2001 | pmid = 11238449 | pmc = 2198811 | doi = 10.1083/jcb.152.5.923}}{{cite web | title = Entrez Gene: hook homolog 2 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29911}}
Function
Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.
References
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Further reading
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- {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }}
- {{cite journal |vauthors=Xu L, Sowa ME, Chen J, etal |title=An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex. |journal=Mol. Biol. Cell |volume=19 |issue= 12 |pages= 5059–71 |year= 2008 |pmid= 18799622 |doi= 10.1091/mbc.E08-05-0473 |pmc=2592673}}
- {{cite journal |vauthors=Moynihan KL, Pooley R, Miller PM, etal |title=Murine CENP-F regulates centrosomal microtubule nucleation and interacts with Hook2 at the centrosome. |journal=Mol. Biol. Cell |volume=20 |issue= 22 |pages= 4790–803 |year= 2009 |pmid= 19793914 |doi= 10.1091/mbc.E09-07-0560 |pmc=2777108}}
- {{cite journal |vauthors=Szebenyi G, Wigley WC, Hall B, etal |title=Hook2 contributes to aggresome formation. |journal=BMC Cell Biol. |volume=8 |pages= 19 |year= 2007 |pmid= 17540036 |doi= 10.1186/1471-2121-8-19 |pmc=1896156 |doi-access=free }}
- {{cite journal |vauthors=Szebenyi G, Hall B, Yu R, etal |title=Hook2 localizes to the centrosome, binds directly to centriolin/CEP110 and contributes to centrosomal function. |journal=Traffic |volume=8 |issue= 1 |pages= 32–46 |year= 2007 |pmid= 17140400 |doi= 10.1111/j.1600-0854.2006.00511.x |s2cid=19664393 }}
- {{cite journal |vauthors=Simpson F, Martin S, Evans TM, etal |title=A novel hook-related protein family and the characterization of hook-related protein 1. |journal=Traffic |volume=6 |issue= 6 |pages= 442–58 |year= 2005 |pmid= 15882442 |doi= 10.1111/j.1600-0854.2005.00289.x |s2cid=25389776 |doi-access=free }}
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