HOOK3

{{Short description|Protein-coding gene in the species Homo sapiens}}

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Protein Hook homolog 3 is a protein that in humans is encoded by the HOOK3 gene.{{cite journal |vauthors=Kramer H, Phistry M | title = Genetic analysis of hook, a gene required for endocytic trafficking in drosophila | journal = Genetics | volume = 151 | issue = 2 | pages = 675–84 |date=Mar 1999 | doi = 10.1093/genetics/151.2.675 | pmid = 9927460 | pmc = 1460498 }}{{cite web | title = Entrez Gene: HOOK3 hook homolog 3 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84376}}

Function

Hook proteins are cytosolic coiled coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.

References

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Further reading

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  • {{cite journal |vauthors=Walenta JH, Didier AJ, Liu X, Krämer H |title=The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins. |journal=J. Cell Biol. |volume=152 |issue= 5 |pages= 923–34 |year= 2001 |pmid= 11238449 |doi=10.1083/jcb.152.5.923 | pmc=2198811 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Shotland Y, Krämer H, Groisman EA |title=The Salmonella SpiC protein targets the mammalian Hook3 protein function to alter cellular trafficking. |journal=Mol. Microbiol. |volume=49 |issue= 6 |pages= 1565–76 |year= 2003 |pmid= 12950921 |doi=10.1046/j.1365-2958.2003.03668.x |s2cid=30972454 |doi-access=free }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
  • {{cite journal |vauthors=Kaiser F, Kaufmann SH, Zerrahn J |title=IIGP, a member of the IFN inducible and microbial defense mediating 47 kDa GTPase family, interacts with the microtubule binding protein hook3. |journal=J. Cell Sci. |volume=117 |issue= Pt 9 |pages= 1747–56 |year= 2004 |pmid= 15075236 |doi= 10.1242/jcs.01039 |doi-access= |s2cid=294834 }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Simpson F, Martin S, Evans TM, etal |title=A novel hook-related protein family and the characterization of hook-related protein 1. |journal=Traffic |volume=6 |issue= 6 |pages= 442–58 |year= 2005 |pmid= 15882442 |doi= 10.1111/j.1600-0854.2005.00289.x |s2cid=25389776 |doi-access=free }}
  • {{cite journal |vauthors=Beausoleil SA, Villén J, Gerber SA, etal |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 |s2cid=14294292 }}
  • {{cite journal |vauthors=Sano H, Ishino M, Krämer H, etal |title=The microtubule-binding protein Hook3 interacts with a cytoplasmic domain of scavenger receptor A. |journal=J. Biol. Chem. |volume=282 |issue= 11 |pages= 7973–81 |year= 2007 |pmid= 17237231 |doi= 10.1074/jbc.M611537200 |doi-access= free }}
  • {{cite journal |vauthors=Ciampi R, Giordano TJ, Wikenheiser-Brokamp K, etal |title=HOOK3-RET: a novel type of RET/PTC rearrangement in papillary thyroid carcinoma. |journal=Endocr. Relat. Cancer |volume=14 |issue= 2 |pages= 445–52 |year= 2007 |pmid= 17639057 |doi= 10.1677/ERC-07-0039 |doi-access= free }}

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