HOXB2

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with pancreatic cancer.

• Homeobox

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• {{cite journal | vauthors = Lavelle D, Ducksworth J, Eves E, Gomes G, Keller M, Heller P, DeSimone J | title = A homeodomain protein binds to gamma-globin gene regulatory sequences | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 88 | issue = 16 | pages = 7318–22 | date = Aug 1991 | pmid = 1871139 | pmc = 52286 | doi = 10.1073/pnas.88.16.7318 | bibcode = 1991PNAS...88.7318L | doi-access = free }}
• {{cite journal | vauthors = Giampaolo A, Acampora D, Zappavigna V, Pannese M, D'Esposito M, Carè A, Faiella A, Stornaiuolo A, Russo G, Simeone A | title = Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system | journal = Differentiation; Research in Biological Diversity | volume = 40 | issue = 3 | pages = 191–7 | date = Jun 1989 | pmid = 2570724 | doi = 10.1111/j.1432-0436.1989.tb00598.x }}
• {{cite journal | vauthors = Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E | title = The human HOX gene family | journal = Nucleic Acids Research | volume = 17 | issue = 24 | pages = 10385–402 | date = Dec 1989 | pmid = 2574852 | pmc = 335308 | doi = 10.1093/nar/17.24.10385 }}
• {{cite journal | vauthors = Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A | title = Organization of human class I homeobox genes | journal = Genome | volume = 31 | issue = 2 | pages = 745–56 | year = 1990 | pmid = 2576652 | doi = 10.1139/g89-133 }}
• {{cite journal | vauthors = Kongsuwan K, Webb E, Housiaux P, Adams JM | title = Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages | journal = The EMBO Journal | volume = 7 | issue = 7 | pages = 2131–8 | date = Jul 1988 | pmid = 2901346 | pmc = 454515 | doi = 10.1002/j.1460-2075.1988.tb03052.x}}
• {{cite journal | vauthors = Vieille-Grosjean I, Huber P | title = Transcription factor GATA-1 regulates human HOXB2 gene expression in erythroid cells | journal = The Journal of Biological Chemistry | volume = 270 | issue = 9 | pages = 4544–50 | date = Mar 1995 | pmid = 7876223 | doi = 10.1074/jbc.270.9.4544 | doi-access = free }}
• {{cite journal | vauthors = Guazzi S, Lonigro R, Pintonello L, Boncinelli E, Di Lauro R, Mavilio F | title = The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins | journal = The EMBO Journal | volume = 13 | issue = 14 | pages = 3339–47 | date = Jul 1994 | pmid = 7913891 | pmc = 395231 | doi = 10.1002/j.1460-2075.1994.tb06636.x}}
• {{cite journal | vauthors = Guazzi S, Pintonello ML, Viganò A, Boncinelli E | title = Regulatory interactions between the human HOXB1, HOXB2, and HOXB3 proteins and the upstream sequence of the Otx2 gene in embryonal carcinoma cells | journal = The Journal of Biological Chemistry | volume = 273 | issue = 18 | pages = 11092–9 | date = May 1998 | pmid = 9556594 | doi = 10.1074/jbc.273.18.11092 | doi-access = free }}
• {{cite journal | vauthors = Davenne M, Maconochie MK, Neun R, Pattyn A, Chambon P, Krumlauf R, Rijli FM | title = Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal development in the rostral hindbrain | journal = Neuron | volume = 22 | issue = 4 | pages = 677–91 | date = Apr 1999 | pmid = 10230789 | doi = 10.1016/S0896-6273(00)80728-X | doi-access = free }}
• {{cite journal | vauthors = Case SS, Huber P, Lloyd JA | title = The gammaPE complex contains both SATB1 and HOXB2 and has positive and negative roles in human gamma-globin gene regulation | journal = DNA and Cell Biology | volume = 18 | issue = 11 | pages = 805–17 | date = Nov 1999 | pmid = 10595394 | doi = 10.1089/104454999314809 }}
• {{cite journal | vauthors = Golpon HA, Geraci MW, Moore MD, Miller HL, Miller GJ, Tuder RM, Voelkel NF | title = HOX genes in human lung: altered expression in primary pulmonary hypertension and emphysema | journal = The American Journal of Pathology | volume = 158 | issue = 3 | pages = 955–66 | date = Mar 2001 | pmid = 11238043 | pmc = 1850338 | doi = 10.1016/S0002-9440(10)64042-4 }}
• {{cite journal | vauthors = Shen WF, Krishnan K, Lawrence HJ, Largman C | title = The HOX homeodomain proteins block CBP histone acetyltransferase activity | journal = Molecular and Cellular Biology | volume = 21 | issue = 21 | pages = 7509–22 | date = Nov 2001 | pmid = 11585930 | pmc = 99922 | doi = 10.1128/MCB.21.21.7509-7522.2001 }}
• {{cite journal | vauthors = Liu X, Zhang X | title = Effect of anti-sense oligodeoxynucleotides homeobox B2 on the proliferation and expression of primary human umbilical vein endothelial cells | journal = Chinese Journal of Traumatology = Zhonghua Chuang Shang Za Zhi | volume = 5 | issue = 1 | pages = 12–5 | date = Feb 2002 | pmid = 11835749 }}
• {{cite journal | vauthors = Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N | title = Complete mutation analysis panel of the 39 human HOX genes | journal = Teratology | volume = 65 | issue = 2 | pages = 50–62 | date = Feb 2002 | pmid = 11857506 | doi = 10.1002/tera.10009 }}
• {{cite journal | vauthors = Ivins S, Pemberton K, Guidez F, Howell L, Krumlauf R, Zelent A | title = Regulation of Hoxb2 by APL-associated PLZF protein | journal = Oncogene | volume = 22 | issue = 24 | pages = 3685–97 | date = Jun 2003 | pmid = 12802276 | doi = 10.1038/sj.onc.1206328 | doi-access = free }}
• {{cite journal | vauthors = Segara D, Biankin AV, Kench JG, Langusch CC, Dawson AC, Skalicky DA, Gotley DC, Coleman MJ, Sutherland RL, Henshall SM | title = Expression of HOXB2, a retinoic acid signaling target in pancreatic cancer and pancreatic intraepithelial neoplasia | journal = Clinical Cancer Research | volume = 11 | issue = 9 | pages = 3587–96 | date = May 2005 | pmid = 15867264 | doi = 10.1158/1078-0432.CCR-04-1813 | s2cid = 15485235 | doi-access = }}

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• {{MeshName|HOXB2+protein,+human}}

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{{Transcription factors|g3}}

Category:Transcription factors

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