HOXB5

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue.

• Myeloid tissue

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• {{cite journal | vauthors = Galang CK, Hauser CA | title = Cooperative DNA binding of the highly conserved human Hox 2.1 homeodomain gene product | journal = The New Biologist | volume = 4 | issue = 5 | pages = 558–68 | date = May 1992 | pmid = 1355360 }}
• {{cite journal | vauthors = Peverali FA, D'Esposito M, Acampora D, Bunone G, Negri M, Faiella A, Stornaiuolo A, Pannese M, Migliaccio E, Simeone A | title = Expression of HOX homeogenes in human neuroblastoma cell culture lines | journal = Differentiation; Research in Biological Diversity | volume = 45 | issue = 1 | pages = 61–9 | date = Oct 1990 | pmid = 1981366 | doi = 10.1111/j.1432-0436.1990.tb00458.x }}
• {{cite journal | vauthors = Giampaolo A, Acampora D, Zappavigna V, Pannese M, D'Esposito M, Carè A, Faiella A, Stornaiuolo A, Russo G, Simeone A | title = Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system | journal = Differentiation; Research in Biological Diversity | volume = 40 | issue = 3 | pages = 191–7 | date = Jun 1989 | pmid = 2570724 | doi = 10.1111/j.1432-0436.1989.tb00598.x }}
• {{cite journal | vauthors = Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E | title = The human HOX gene family | journal = Nucleic Acids Research | volume = 17 | issue = 24 | pages = 10385–402 | date = Dec 1989 | pmid = 2574852 | pmc = 335308 | doi = 10.1093/nar/17.24.10385 }}
• {{cite journal | vauthors = Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A | title = Organization of human class I homeobox genes | journal = Genome | volume = 31 | issue = 2 | pages = 745–56 | year = 1990 | pmid = 2576652 | doi = 10.1139/g89-133 }}
• {{cite journal | vauthors = Rabin M, Ferguson-Smith A, Hart CP, Ruddle FH | title = Cognate homeo-box loci mapped on homologous human and mouse chromosomes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 83 | issue = 23 | pages = 9104–8 | date = Dec 1986 | pmid = 2878432 | pmc = 387083 | doi = 10.1073/pnas.83.23.9104 | bibcode = 1986PNAS...83.9104R | doi-access = free }}
• {{cite journal | vauthors = Hart CP, Awgulewitsch A, Fainsod A, McGinnis W, Ruddle FH | title = Homeo box gene complex on mouse chromosome 11: molecular cloning, expression in embryogenesis, and homology to a human homeo box locus | journal = Cell | volume = 43 | issue = 1 | pages = 9–18 | date = Nov 1985 | pmid = 3000607 | doi = 10.1016/0092-8674(85)90007-8 | s2cid = 44802225 }}
• {{cite journal | vauthors = Xu WM, Gorman PA, Rider SH, Hedge PJ, Moore G, Prichard C, Sheer D, Solomon E | title = Construction of a genetic map of human chromosome 17 by use of chromosome-mediated gene transfer | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 85 | issue = 22 | pages = 8563–7 | date = Nov 1988 | pmid = 3186746 | pmc = 282499 | doi = 10.1073/pnas.85.22.8563 | bibcode = 1988PNAS...85.8563X | doi-access = free }}
• {{cite journal | vauthors = Simeone A, Mavilio F, Bottero L, Giampaolo A, Russo G, Faiella A, Boncinelli E, Peschle C | title = A human homoeo box gene specifically expressed in spinal cord during embryonic development | journal = Nature | volume = 320 | issue = 6064 | pages = 763–5 | year = 1986 | pmid = 3453105 | doi = 10.1038/320763a0 | bibcode = 1986Natur.320..763S | s2cid = 4322447 }}
• {{cite journal | vauthors = Hauser CA, Joyner AL, Klein RD, Learned TK, Martin GR, Tjian R | title = Expression of homologous homeo-box-containing genes in differentiated human teratocarcinoma cells and mouse embryos | journal = Cell | volume = 43 | issue = 1 | pages = 19–28 | date = Nov 1985 | pmid = 4075393 | doi = 10.1016/0092-8674(85)90008-X | s2cid = 46477046 }}
• {{cite journal | vauthors = Levine M, Rubin GM, Tjian R | title = Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila | journal = Cell | volume = 38 | issue = 3 | pages = 667–73 | date = Oct 1984 | pmid = 6091895 | doi = 10.1016/0092-8674(84)90261-7 | s2cid = 28848659 }}
• {{cite journal | vauthors = Galang CK, Hauser CA | title = Cooperative DNA binding of the human HoxB5 (Hox-2.1) protein is under redox regulation in vitro | journal = Molecular and Cellular Biology | volume = 13 | issue = 8 | pages = 4609–17 | date = Aug 1993 | pmid = 8101633 | pmc = 360087 | doi = 10.1128/mcb.13.8.4609}}
• {{cite journal | vauthors = Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B | title = Fine mapping of human HOX gene clusters | journal = Cytogenetics and Cell Genetics | volume = 73 | issue = 1–2 | pages = 114–5 | year = 1996 | pmid = 8646877 | doi = 10.1159/000134320 }}
• {{cite journal | vauthors = Kuliev A, Kukharenko V, Morozov G, Freidine M, Rechitsky S, Verlinsky O, Ivakhnenko V, Gindilis V, Strom C, Verlinsky Y | title = Expression of homebox-containing genes in human preimplantation development and in embryos with chromosomal aneuploidies | journal = Journal of Assisted Reproduction and Genetics | volume = 13 | issue = 2 | pages = 177–81 | date = Feb 1996 | pmid = 8688592 | doi = 10.1007/BF02072541 | s2cid = 28126784 }}
• {{cite journal | vauthors = Sakach M, Safaei R | title = Localization of the HoxB5 protein in the developing CNS of late gestational mouse embryos | journal = International Journal of Developmental Neuroscience | volume = 14 | issue = 5 | pages = 567–73 | date = Aug 1996 | pmid = 8930688 | doi = 10.1016/0736-5748(96)00052-4 | s2cid = 137937 }}
• {{cite journal | vauthors = Archavachotikul K, Ciccone TJ, Chinoy MR, Nielsen HC, Volpe MV | title = Thyroid hormone affects embryonic mouse lung branching morphogenesis and cellular differentiation | journal = American Journal of Physiology. Lung Cellular and Molecular Physiology | volume = 282 | issue = 3 | pages = L359-69 | date = Mar 2002 | pmid = 11839528 | doi = 10.1152/ajplung.00400.2000 | s2cid = 88376626 }}
• {{cite journal | vauthors = Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N | title = Complete mutation analysis panel of the 39 human HOX genes | journal = Teratology | volume = 65 | issue = 2 | pages = 50–62 | date = Feb 2002 | pmid = 11857506 | doi = 10.1002/tera.10009 }}

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• {{MeshName|HOXB5+protein,+human}}
• {{PDBe-KB2|P02833|Drosophila melanogaster Homeotic protein antennapedia}}

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Category:Transcription factors

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