HRBL
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Arf-GAP domain and FG repeats-containing protein 2 is a protein that in humans is encoded by the AGFG2 gene.{{cite journal |vauthors=Glockner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A | title = Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes | journal = Genome Res | volume = 8 | issue = 10 | pages = 1060–73 |date=Dec 1998 | pmid = 9799793 | pmc = 310788 | doi = 10.1101/gr.8.10.1060}}{{cite web | title = Entrez Gene: HRBL HIV-1 Rev binding protein-like| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3268| accessdate = }}
This gene is a member of the HIV-1 Rev binding protein (HRB) family and encodes a protein with one Arf-GAP zinc finger domain, several phe-gly (FG) motifs, and four asn-pro-phe (NPF) motifs. This protein interacts with Eps15 homology (EH) domains and plays a role in the Rev export pathway, which mediates the nucleocytoplasmic transfer of proteins and RNAs. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
References
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Further reading
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- {{cite journal |vauthors=Wong WT, Schumacher C, Salcini AE, etal |title=A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 21 |pages= 9530–4 |year= 1995 |pmid= 7568168 |doi=10.1073/pnas.92.21.9530 | pmc=40835 |bibcode=1995PNAS...92.9530W |doi-access=free }}
- {{cite journal |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 |doi-access=free }}
- {{cite journal |vauthors=Salcini AE, Confalonieri S, Doria M, etal |title=Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module. |journal=Genes Dev. |volume=11 |issue= 17 |pages= 2239–49 |year= 1997 |pmid= 9303539 |doi=10.1101/gad.11.17.2239 | pmc=275390 }}
- {{cite journal |vauthors=Doria M, Salcini AE, Colombo E, etal |title=The eps15 homology (EH) domain-based interaction between eps15 and hrb connects the molecular machinery of endocytosis to that of nucleocytosolic transport. |journal=J. Cell Biol. |volume=147 |issue= 7 |pages= 1379–84 |year= 2000 |pmid= 10613896 |doi=10.1083/jcb.147.7.1379 | pmc=2174238 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Scherer SW, Cheung J, MacDonald JR, etal |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 | pmc=2882961 |doi= 10.1126/science.1083423 |bibcode=2003Sci...300..767S }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
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