HSC

• Hughes Systique Corporation
• Halifax Shopping Centre
• Harmonized System Code
• Harsco Corporation

• HSC50 (Hierarchical Storage Controller), using DEC Mass Storage Control Protocol
• Hughes Systique Corporation

• Health and Social Care in Northern Ireland
• Hematopoietic stem cell
• Hepatic stellate cell
• Hospital for Sick Children, Toronto, Canada
• Hydraulic Sinus Condensing, a technique used in dentistry to lift the sinus
• Hysteroscopy, a method for looking into the uterus via the cervix

• Harare Sports Club, sports venue in Zimbabwe
• Health Service Commissioner for England
• Health Sponsorship Council
• Heraldry Society of Canada
• Huntington Society of Canada
• Health and Safety Commission
• Horizon Scanning Centre (HSC)
• United States Homeland Security Council

• Higher School Certificate (New South Wales), Australia
• Higher School Certificate (Victoria), Australia
• Higher School Certificate (UK)
• Higher Secondary Certificate (South Asian countries)

• Hampden–Sydney College
• Hillfield Strathallan College, private school in Hamilton, Ontario, Canada
• Hsin Sheng College of Medical Care and Management, private junior college in Taoyuan City, Taiwan

• Hindu Students Council

• High-speed craft
• Houston Ship Channel
• Hyper Suprime-Cam, camera for Subaru Telescope
• Mauser HSc, pistol
• Shaoguan Guitou Airport, IATA code

{{disambig}}