HSF2

HSF2, as well as the related gene HSF1, encodes a protein that binds specifically to the heat-shock element and has homology to HSFs of other species. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Although the names HSF1 and HSF2 were chosen for historical reasons, these peptides should be referred to as heat-shock transcription factors.

HSF2 has been shown to interact with Nucleoporin 62{{cite journal | vauthors = Yoshima T, Yura T, Yanagi H | title = The trimerization domain of human heat shock factor 2 is able to interact with nucleoporin p62 | journal = Biochem. Biophys. Res. Commun. | volume = 240 | issue = 1 | pages = 228–33 | date = Nov 1997 | pmid = 9367915 | doi = 10.1006/bbrc.1997.7662 }} and HSF1.{{cite journal | vauthors = He H, Soncin F, Grammatikakis N, Li Y, Siganou A, Gong J, Brown SA, Kingston RE, Calderwood SK | title = Elevated expression of heat shock factor (HSF) 2A stimulates HSF1-induced transcription during stress | journal = J. Biol. Chem. | volume = 278 | issue = 37 | pages = 35465–75 | date = Sep 2003 | pmid = 12813038 | doi = 10.1074/jbc.M304663200 | doi-access = free }}

• Heat shock factor

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• {{cite journal | vauthors = Walsh D, Li Z, Wu Y, Nagata K | title = Heat shock and the role of the HSPs during neural plate induction in early mammalian CNS and brain development. | journal = Cell. Mol. Life Sci. | volume = 53 | issue = 2 | pages = 198–211 | year = 1997 | pmid = 9118008 | doi = 10.1007/PL00000592 | s2cid = 32425345 | pmc = 11147247 }}
• {{cite journal | vauthors = Sarge KD, Zimarino V, Holm K, Wu C, Morimoto RI | title = Cloning and characterization of two mouse heat shock factors with distinct inducible and constitutive DNA-binding ability. | journal = Genes Dev. | volume = 5 | issue = 10 | pages = 1902–11 | year = 1991 | pmid = 1717345 | doi = 10.1101/gad.5.10.1902 | doi-access = free }}
• {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
• {{cite journal | vauthors = Sheldon LA, Kingston RE | title = Hydrophobic coiled-coil domains regulate the subcellular localization of human heat shock factor 2. | journal = Genes Dev. | volume = 7 | issue = 8 | pages = 1549–58 | year = 1993 | pmid = 8339932 | doi = 10.1101/gad.7.8.1549 | doi-access = free }}
• {{cite journal | vauthors = Yoshima T, Yura T, Yanagi H | title = The trimerization domain of human heat shock factor 2 is able to interact with nucleoporin p62. | journal = Biochem. Biophys. Res. Commun. | volume = 240 | issue = 1 | pages = 228–33 | year = 1997 | pmid = 9367915 | doi = 10.1006/bbrc.1997.7662 }}
• {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
• {{cite journal | vauthors = Yoshima T, Yura T, Yanagi H | title = Novel testis-specific protein that interacts with heat shock factor 2. | journal = Gene | volume = 214 | issue = 1–2 | pages = 139–46 | year = 1998 | pmid = 9651507 | doi = 10.1016/S0378-1119(98)00208-X }}
• {{cite journal | vauthors = Hong Y, Sarge KD | title = Regulation of protein phosphatase 2A activity by heat shock transcription factor 2. | journal = J. Biol. Chem. | volume = 274 | issue = 19 | pages = 12967–70 | year = 1999 | pmid = 10224043 | doi = 10.1074/jbc.274.19.12967 | doi-access = free }}
• {{cite journal | vauthors = Goodson ML, Hong Y, Rogers R, Matunis MJ, Park-Sarge OK, Sarge KD | title = Sumo-1 modification regulates the DNA binding activity of heat shock transcription factor 2, a promyelocytic leukemia nuclear body associated transcription factor. | journal = J. Biol. Chem. | volume = 276 | issue = 21 | pages = 18513–8 | year = 2001 | pmid = 11278381 | doi = 10.1074/jbc.M008066200 | doi-access = free }}
• {{cite journal | vauthors = Nykänen P, Alastalo TP, Ahlskog J, Horelli-Kuitunen N, Pirkkala L, Sistonen L | title = Genomic organization and promoter analysis of the human heat shock factor 2 gene. | journal = Cell Stress & Chaperones | volume = 6 | issue = 4 | pages = 377–85 | year = 2002 | doi = 10.1379/1466-1268(2001)006<0377:goapao>2.0.co;2 | doi-broken-date = 2024-11-02 | pmid = 11795475 | pmc = 434421 }}
• {{cite journal | vauthors = He H, Soncin F, Grammatikakis N, Li Y, Siganou A, Gong J, Brown SA, Kingston RE, Calderwood SK | title = Elevated expression of heat shock factor (HSF) 2A stimulates HSF1-induced transcription during stress. | journal = J. Biol. Chem. | volume = 278 | issue = 37 | pages = 35465–75 | year = 2003 | pmid = 12813038 | doi = 10.1074/jbc.M304663200 | doi-access = free }}
• {{cite journal | vauthors = Alastalo TP, Hellesuo M, Sandqvist A, Hietakangas V, Kallio M, Sistonen L | title = Formation of nuclear stress granules involves HSF2 and coincides with the nucleolar localization of Hsp70. | journal = J. Cell Sci. | volume = 116 | issue = Pt 17 | pages = 3557–70 | year = 2004 | pmid = 12865437 | doi = 10.1242/jcs.00671 | doi-access = free }}
• {{cite journal | vauthors = Roccisana JL, Kawanabe N, Kajiya H, Koide M, Roodman GD, Reddy SV | title = Functional role for heat shock factors in the transcriptional regulation of human RANK ligand gene expression in stromal/osteoblast cells. | journal = J. Biol. Chem. | volume = 279 | issue = 11 | pages = 10500–7 | year = 2004 | pmid = 14699143 | doi = 10.1074/jbc.M303727200 | doi-access = free }}
• {{cite journal | vauthors = Xing H, Wilkerson DC, Mayhew CN, Lubert EJ, Skaggs HS, Goodson ML, Hong Y, Park-Sarge OK, Sarge KD | title = Mechanism of hsp70i gene bookmarking. | journal = Science | volume = 307 | issue = 5708 | pages = 421–3 | year = 2005 | pmid = 15662014 | doi = 10.1126/science.1106478 | bibcode = 2005Sci...307..421X | s2cid = 37132180 }}
• {{cite journal | vauthors = Anckar J, Hietakangas V, Denessiouk K, Thiele DJ, Johnson MS, Sistonen L | title = Inhibition of DNA binding by differential sumoylation of heat shock factors. | journal = Mol. Cell. Biol. | volume = 26 | issue = 3 | pages = 955–64 | year = 2006 | pmid = 16428449 | pmc = 1347039 | doi = 10.1128/MCB.26.3.955-964.2006 }}

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• {{MeshName|HSF2+protein,+human}}

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{{Transcription factors|g3}}

Category:Transcription factors

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