HSF4
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Heat shock factor protein 4 is a protein that in humans is encoded by the HSF4 gene.{{cite journal |vauthors=Nakai A, Tanabe M, Kawazoe Y, Inazawa J, Morimoto RI, Nagata K | title = HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator | journal = Mol Cell Biol | volume = 17 | issue = 1 | pages = 469–81 |date=Jan 1997 | pmid = 8972228 | pmc = 231772 | doi = 10.1128/mcb.17.1.469}}{{cite journal |vauthors=Tanabe M, Sasai N, Nagata K, Liu XD, Liu PC, Thiele DJ, Nakai A | title = The mammalian HSF4 gene generates both an activator and a repressor of heat shock genes by alternative splicing | journal = J Biol Chem | volume = 274 | issue = 39 | pages = 27845–56 |date=Nov 1999 | pmid = 10488131 | doi =10.1074/jbc.274.39.27845 | doi-access = free }}{{cite journal |vauthors=Bu L, Jin Y, Shi Y, Chu R, Ban A, Eiberg H, Andres L, Jiang H, Zheng G, Qian M, Cui B, Xia Y, Liu J, Hu L, Zhao G, Hayden MR, Kong X | title = Mutant DNA-binding domain of HSF4 is associated with autosomal dominant lamellar and Marner cataract | journal = Nat Genet | volume = 31 | issue = 3 | pages = 276–8 |date=Jun 2002 | pmid = 12089525 | doi = 10.1038/ng921 | s2cid = 27368940 }}{{cite web | title = Entrez Gene: HSF4 heat shock transcription factor 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3299}}
Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described.
See also
References
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Further reading
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- {{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
- {{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
- {{cite journal |vauthors=Dias Neto E, Correa RG, Verjovski-Almeida S, etal |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=10.1073/pnas.97.7.3491 | pmc=16267 |bibcode=2000PNAS...97.3491D |doi-access=free }}
- {{cite journal |vauthors=Smaoui N, Beltaief O, BenHamed S, etal |title=A homozygous splice mutation in the HSF4 gene is associated with an autosomal recessive congenital cataract. |journal=Invest. Ophthalmol. Vis. Sci. |volume=45 |issue= 8 |pages= 2716–21 |year= 2004 |pmid= 15277496 |doi= 10.1167/iovs.03-1370 |doi-access= free }}
- {{cite journal |vauthors=Somasundaram T, Bhat SP |title=Developmentally dictated expression of heat shock factors: exclusive expression of HSF4 in the postnatal lens and its specific interaction with alphaB-crystallin heat shock promoter. |journal=J. Biol. Chem. |volume=279 |issue= 43 |pages= 44497–503 |year= 2004 |pmid= 15308659 |doi= 10.1074/jbc.M405813200 |doi-access= free }}
- {{cite journal |vauthors=Forshew T, Johnson CA, Khaliq S, etal |title=Locus heterogeneity in autosomal recessive congenital cataracts: linkage to 9q and germline HSF4 mutations. |journal=Hum. Genet. |volume=117 |issue= 5 |pages= 452–9 |year= 2005 |pmid= 15959809 |doi= 10.1007/s00439-005-1309-9 |s2cid=21135251 }}
- {{cite journal |vauthors=Oh JH, Yang JO, Hahn Y, etal |title=Transcriptome analysis of human gastric cancer. |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942–54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2 |s2cid=69278 }}
- {{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
- {{cite journal |vauthors=Tu N, Hu Y, Mivechi NF |title=Heat shock transcription factor (Hsf)-4b recruits Brg1 during the G1 phase of the cell cycle and regulates the expression of heat shock proteins. |journal=J. Cell. Biochem. |volume=98 |issue= 6 |pages= 1528–42 |year= 2006 |pmid= 16552721 |doi= 10.1002/jcb.20865 |s2cid=36553127 }}
- {{cite journal |vauthors=Ke T, Wang QK, Ji B, etal |title=Novel HSF4 mutation causes congenital total white cataract in a Chinese family. |journal=Am. J. Ophthalmol. |volume=142 |issue= 2 |pages= 298–303 |year= 2006 |pmid= 16876512 |doi= 10.1016/j.ajo.2006.03.056 }}
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External links
- {{MeshName|HSF4+protein,+human}}
{{NLM content}}
{{Transcription factors|g3}}
Category:Transcription factors
{{gene-16-stub}}