HSR

• Historical Social Research, a quarterly journal
• Honkai: Star Rail, a 2023 gacha video game

• Health services research
• Heat shock response, via HSPA1A gene
• Homogeneously staining region

• Hidden surface removal
• Hierarchical state routing
• High-availability Seamless Redundancy

{{seealso|#Transport}}

• Haliburton Scout Reserve, a Scouts Canada camp
• Hochschule für Technik Rapperswil, a university in St. Gallen, Switzerland
• HSR Layout, a suburb of Bangalore, India

• Hamilton Street Railway, a transit agency in Ontario, Canada
• High-speed rail
• Higher-speed rail
• High-Speed Research Program, a 1990–1999 NASA supersonic jet program
• Hisar Junction railway station, in Haryana, India
• Historic Sportscar Racing, an American historic motorsport series
• Holyoke Street Railway, a former transit system in western Massachusetts
• Hot Springs Municipal Airport, South Dakota, US
• Mitsubishi HSR, a concept car

• Hart–Scott–Rodino Antitrust Improvements Act, a 1976 US federal law

{{Disambiguation}}