HTATSF1

Whereas most DNA sequence-specific transcription factors increase the rate of initiation and interact with enhancer or promoter DNA, human immunodeficiency virus-1 (HIV-1) Tat predominantly stimulates elongation and interacts with the trans-acting responsive (TAR) RNA element. Tat is essential for HIV replication.

HTATSF1 has also been shown to be involved in intron retention, and is associated with splicing of mRNAs that encode ribosomal proteins.{{Cite journal |last1=Corsini |first1=Nina S. |last2=Peer |first2=Angela M. |last3=Moeseneder |first3=Paul |last4=Roiuk |first4=Mykola |last5=Burkard |first5=Thomas R. |last6=Theussl |first6=Hans-Christian |last7=Moll |first7=Isabella |last8=Knoblich |first8=Juergen A. |date=April 2018 |title=Coordinated Control of mRNA and rRNA Processing Controls Embryonic Stem Cell Pluripotency and Differentiation |journal=Cell Stem Cell |language=English |volume=22 |issue=4 |pages=543–558.e12 |doi=10.1016/j.stem.2018.03.002 |issn=1934-5909 |pmid=29625069|doi-access=free }} It is also associated with a naïve pluripotent state, although the relationship is complex and is strongly affected by other pluripotency factors such as Nanog and KLF2.

HTATSF1 has been shown to interact with SUPT5H{{cite journal |last=Kim |first=J B |author2=Yamaguchi Y |author3=Wada T |author4=Handa H |author5=Sharp P A |date=Sep 1999 |title=Tat-SF1 protein associates with RAP30 and human SPT5 proteins |journal=Mol. Cell. Biol. |volume=19 |issue=9 |pages=5960–8 | issn = 0270-7306| pmid = 10454543 |pmc=84462 | doi=10.1128/mcb.19.9.5960}} and GTF2F2.

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{{refbegin | 2}}

• {{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
• {{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
• {{cite journal |vauthors=Zhou Q, Chen D, Pierstorff E, Luo K |title=Transcription elongation factor P-TEFb mediates Tat activation of HIV-1 transcription at multiple stages |journal=EMBO J. |volume=17 |issue= 13 |pages= 3681–91 |year= 1998 |pmid= 9649438 |doi= 10.1093/emboj/17.13.3681 | pmc=1170704 }}
• {{cite journal |vauthors=Yan D, Perriman R, Igel H, etal |title=CUS2, a yeast homolog of human Tat-SF1, rescues function of misfolded U2 through an unusual RNA recognition motif |journal=Mol. Cell. Biol. |volume=18 |issue= 9 |pages= 5000–9 |year= 1998 |pmid= 9710584 |doi= 10.1128/MCB.18.9.5000| pmc=109085 }}
• {{cite journal |vauthors=Li XY, Green MR |title=The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor |journal=Genes Dev. |volume=12 |issue= 19 |pages= 2992–6 |year= 1998 |pmid= 9765201 |doi=10.1101/gad.12.19.2992 | pmc=317190 }}
• {{cite journal |vauthors=Parada CA, Roeder RG |title=A novel RNA polymerase II-containing complex potentiates Tat-enhanced HIV-1 transcription |journal=EMBO J. |volume=18 |issue= 13 |pages= 3688–701 |year= 1999 |pmid= 10393184 |doi= 10.1093/emboj/18.13.3688 | pmc=1171446 }}
• {{cite journal |vauthors=Kim JB, Yamaguchi Y, Wada T, etal |title=Tat-SF1 protein associates with RAP30 and human SPT5 proteins |journal=Mol. Cell. Biol. |volume=19 |issue= 9 |pages= 5960–8 |year= 1999 |pmid= 10454543 |doi= 10.1128/mcb.19.9.5960| pmc=84462 }}
• {{cite journal |vauthors=Fong YW, Zhou Q |title=Relief of two built-In autoinhibitory mechanisms in P-TEFb is required for assembly of a multicomponent transcription elongation complex at the human immunodeficiency virus type 1 promoter |journal=Mol. Cell. Biol. |volume=20 |issue= 16 |pages= 5897–907 |year= 2000 |pmid= 10913173 |doi=10.1128/MCB.20.16.5897-5907.2000 | pmc=86067 }}
• {{cite journal |vauthors=Suñé C, Goldstrohm AC, Peng J, etal |title=An in vitro transcription system that recapitulates equine infectious anemia virus tat-mediated inhibition of human immunodeficiency virus type 1 Tat activity demonstrates a role for positive transcription elongation factor b and associated proteins in the mechanism of Tat activation |journal=Virology |volume=274 |issue= 2 |pages= 356–66 |year= 2000 |pmid= 10964778 |doi= 10.1006/viro.2000.0480 |doi-access= free }}
• {{cite journal |vauthors=Simmons A, Aluvihare V, McMichael A |title=Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators |journal=Immunity |volume=14 |issue= 6 |pages= 763–77 |year= 2001 |pmid= 11420046 |doi=10.1016/S1074-7613(01)00158-3 |doi-access=free }}
• {{cite journal |vauthors=Fong YW, Zhou Q |title=Stimulatory effect of splicing factors on transcriptional elongation |journal=Nature |volume=414 |issue= 6866 |pages= 929–33 |year= 2002 |pmid= 11780068 |doi= 10.1038/414929a |s2cid=1518837 }}
• {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
• {{cite journal |vauthors=Zhou BY, He JJ |title=Proliferation inhibition of astrocytes, neurons, and non-glial cells by intracellularly expressed human immunodeficiency virus type 1 (HIV-1) Tat protein |journal=Neurosci. Lett. |volume=359 |issue= 3 |pages= 155–8 |year= 2004 |pmid= 15050687 |doi= 10.1016/j.neulet.2004.02.012 |s2cid=3048557 }}
• {{cite journal |vauthors=Ballif BA, Villén J, Beausoleil SA, etal |title=Phosphoproteomic analysis of the developing mouse brain |journal=Mol. Cell. Proteomics |volume=3 |issue= 11 |pages= 1093–101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 |doi-access= free |citeseerx= 10.1.1.567.1545 }}
• {{cite journal |vauthors=Smith MJ, Kulkarni S, Pawson T |title=FF domains of CA150 bind transcription and splicing factors through multiple weak interactions |journal=Mol. Cell. Biol. |volume=24 |issue= 21 |pages= 9274–85 |year= 2004 |pmid= 15485897 |doi= 10.1128/MCB.24.21.9274-9285.2004 | pmc=522232 }}
• {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
• {{cite journal |vauthors=Zhou M, Deng L, Lacoste V, etal |title=Coordination of transcription factor phosphorylation and histone methylation by the P-TEFb kinase during human immunodeficiency virus type 1 transcription |journal=J. Virol. |volume=78 |issue= 24 |pages= 13522–33 |year= 2004 |pmid= 15564463 |doi= 10.1128/JVI.78.24.13522-13533.2004 | pmc=533906 }}
• {{cite journal |vauthors=Ross MT, Grafham DV, Coffey AJ, etal |title=The DNA sequence of the human X chromosome |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 | pmc=2665286 |bibcode=2005Natur.434..325R }}
• {{cite journal |vauthors=Missé D, Gajardo J, Oblet C, etal |title=Soluble HIV-1 gp120 enhances HIV-1 replication in non-dividing CD4+ T cells, mediated via cell signaling and Tat cofactor overexpression |journal=AIDS |volume=19 |issue= 9 |pages= 897–905 |year= 2005 |pmid= 15905670 |doi=10.1097/01.aids.0000171403.07995.92 |s2cid=23688259 |doi-access=free }}

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