Halimadienyl-diphosphate synthase

{{Short description|Class of enzymes}}

{{Infobox enzyme

| Name = Halimadienyl-diphosphate synthase

| EC_number = 5.5.1.16

| CAS_number =

| GO_code =

| image =

| width =

| caption =

}}

Halimadienyl-diphosphate synthase ({{EnzExplorer|5.5.1.16}}, Rv3377c, halimadienyl diphosphate synthase, tuberculosinol diphosphate synthase, halima-5(6),13-dien-15-yl-diphosphate lyase (cyclizing)) is an enzyme with systematic name halima-5,13-dien-15-yl-diphosphate lyase (decyclizing).{{cite journal | vauthors = Nakano C, Okamura T, Sato T, Dairi T, Hoshino T | title = Mycobacterium tuberculosis H37Rv3377c encodes the diterpene cyclase for producing the halimane skeleton | journal = Chemical Communications | issue = 8 | pages = 1016–8 | date = February 2005 | pmid = 15719101 | doi = 10.1039/b415346d }} This enzyme catalyses the following chemical reaction

: geranylgeranyl diphosphate $\backslash rightleftharpoons$ tuberculosinyl diphosphate

This enzyme requires Mg²⁺ for activity.