Hartmut Oschkinat
{{Short description|German structural biologist and professor}}
{{Infobox scientist
| name = Hartmut Oschkinat
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| image = Hartmut Oschkinat group retreat 20171122.jpg
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| caption = Oschkinat in 2016
| birth_date = {{birth date and age|1957|02|28|df=y}}
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| citizenship = German
| nationality = German
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| workplaces = FMP Berlin
Free University of Berlin
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| alma_mater = Goethe University Frankfurt
| thesis_title = Analysis of the conformation of Cyclosporin in solution using NMR-spectroscopy: development and use of new methods
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| thesis_year = 1986
| doctoral_advisor = Horst Kessler
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| awards = Günther Laukien Prize
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| website = {{URL|http://www.leibniz-fmp.de/research/structuralbiology/researchgroups/oschkinat/intro.html}}
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Hartmut Oschkinat (born 28 February 1957) is a German structural biologist and professor for chemistry at the Free University of Berlin. His research focuses on the study of biological systems with solid-state nuclear magnetic resonance.
He is a member of the Editorial Boards of the Journal of Biomolecular NMR and Structure.{{Cite web|url=https://www.springer.com/physics/biophysics+%26+biological+physics/journal/10858?detailsPage=editorialBoard|title=Editorial Board of Journal of Biomolecular NMR|access-date=2017-02-14}}{{Cite web|url=http://www.cell.com/structure/editorial-board|title=Staff and Editorial Board of Structure|access-date=2017-02-14}}
Life and career
Oschkinat studied chemistry at the Johann-Wolfgang-Goethe University of Frankfurt. He received his doctoral degree in 1986 under the supervision of Horst Kessler with the title "Analysis of the conformation of Cyclosporin in solution using NMR-spectroscopy: development and use of new methods." in the field of nuclear magnetic resonance spectroscopy (NMR). After his work as a postdoctoral researcher with Geoffrey Bodenhausen at the University of Lausanne, Oschkinat moved to the Max Planck Institute of Biochemistry in Martinsried in 1987 as a post-doc in the Lab of Marius Clore and Angela Gronenborn. There, he was working with Marius Clore, Angela Gronenborn and the Nobel laureate Robert Huber. After his habilitation at the Technical University of Munich in 1992, Hartmut Oschkinat moved to the European Molecular Biology Laboratory in Heidelberg. Since 1998, he is the head of the department NMR-supported Structural Biology at the Leibniz-Institut für Molekulare Pharmakologie in Berlin.
Research
At the beginning of his career, Oschkinat worked in the field of solution-state NMR, and made fundamental contributions to establish the role of multidimensional NMR spectroscopy in structural biology. After using solution-state NMR spectroscopy to determine three-dimensional structures of soluble proteins such as the pleckstrin homology domain and the WW domain, characterise protein–protein interactions involving the latter, with applications in fragment-based drug discovery, he moved on to focus on the investigation of biological systems by solid-state NMR (ssNMR) with magic angle spinning. His group was the first to solve a protein structure using ssNMR; the structure solved was that of a microcrystalline preparation of a SH3 domain. Since 2005, his research group investigates complex biomolecular systems such as membrane proteins within the native lipid environment, amyloid fibrils, and oligomers. Moreover, he develops methods to address challenging questions in structural biology where ssNMR can be applied with particular advantages, and have made particular contributions to the development of dynamic nuclear polarisation and proton detection using fast magic angle spinning.
Notable Achievements
- 1998: elected to membership of the European Molecular Biology Organization.
- 2009–2011: Acting Director of the Leibniz-Institut für Molekulare Pharmakologie.
- 2012: International Scientific Review Board for the Central European Institute of Technology in Brno, Czech Republic.
- 2013: elected to honorary membership of the National Magnetic Resonance Society of India.
- 2014: one of six awardees of the Günther Laukien Prize, awarded annually at the Experimental Nuclear Magnetic Resonance Conference in the USA.
References
{{Reflist|
refs=
{{cite journal |vauthors=Oschkinat H, Griesinger C, Kraulis PJ, Sørensen OW, Ernst RR, Gronenborn AM, Clore GM |title=Three-dimensional NMR spectroscopy of a protein in solution |journal=Nature |volume=332 |issue=6162 |pages=374–6 |year=1988 |pmid=3352736 |doi=10.1038/332374a0 |bibcode=1988Natur.332..374O |s2cid=4261068 }}
{{cite journal |vauthors=Macias MJ, Musacchio A, Ponstingl H, Nilges M, Saraste M, Oschkinat H |title=Structure of the pleckstrin homology domain from beta-spectrin |journal=Nature |volume=369 |issue=6482 |pages=675–7 |year=1994 |pmid=8208297 |doi=10.1038/369675a0 |bibcode=1994Natur.369..675M |s2cid=4358947 }}
{{cite journal |vauthors=Macias MJ, Hyvönen M, Baraldi E, Schultz J, Sudol M, Saraste M, Oschkinat H |title=Structure of the WW domain of a kinase-associated protein complexed with a proline-rich peptide |journal=Nature |volume=382 |issue=6592 |pages=646–9 |year=1996 |pmid=8757138 |doi=10.1038/382646a0 |bibcode=1996Natur.382..646M |s2cid=4306964 }}
{{cite journal |vauthors=Macias MJ, Gervais V, Civera C, Oschkinat H |title=Structural analysis of WW domains and design of a WW prototype |journal=Nat. Struct. Biol. |volume=7 |issue=5 |pages=375–9 |year=2000 |pmid=10802733 |doi=10.1038/75144 |s2cid=1328841 }}
{{cite journal |vauthors=Hiller M, Krabben L, Vinothkumar KR, Castellani F, van Rossum BJ, Kühlbrandt W, Oschkinat H |title=Solid-state magic-angle spinning NMR of outer-membrane protein G from Escherichia coli |journal=ChemBioChem |volume=6 |issue=9 |pages=1679–84 |year=2005 |pmid=16138308 |doi=10.1002/cbic.200500132 |s2cid=39312280 }}
{{cite journal |vauthors=Ferguson N, Becker J, Tidow H, Tremmel S, Sharpe TD, Krause G, Flinders J, Petrovich M, Berriman J, Oschkinat H, Fersht AR |title=General structural motifs of amyloid protofilaments |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue=44 |pages=16248–53 |year=2006 |pmid=17060612 |pmc=1637568 |doi=10.1073/pnas.0607815103 |doi-access=free |bibcode=2006PNAS..10316248F}}
{{cite journal |vauthors=Joshi M, Vargas C, Boisguerin P, Diehl A, Krause G, Schmieder P, Moelling K, Hagen V, Schade M, Oschkinat H |title=Discovery of low-molecular-weight ligands for the AF6 PDZ domain |journal=Angew. Chem. Int. Ed. Engl. |volume=45 |issue=23 |pages=3790–5 |year=2006 |pmid=16671149 |doi=10.1002/anie.200503965 }}
{{cite journal |vauthors=Pellecchia M, Bertini I, Cowburn D, Dalvit C, Giralt E, Jahnke W, James TL, Homans SW, Kessler H, Luchinat C, Meyer B, Oschkinat H, Peng J, Schwalbe H, Siegal G |title=Perspectives on NMR in drug discovery: a technique comes of age |journal=Nat Rev Drug Discov |volume=7 |issue=9 |pages=738–45 |year=2008 |pmid=19172689 |pmc=2891904 |doi=10.1038/nrd2606 }}
{{cite journal |vauthors=Comellas G, Rienstra CM |title=Protein structure determination by magic-angle spinning solid-state NMR, and insights into the formation, structure, and stability of amyloid fibrils |journal=Annu Rev Biophys |volume=42 |pages=515–36 |year=2013 |pmid=23527778 |doi=10.1146/annurev-biophys-083012-130356 }}
{{cite journal |vauthors=Castellani F, van Rossum B, Diehl A, Schubert M, Rehbein K, Oschkinat H |title=Structure of a protein determined by solid-state magic-angle-spinning NMR spectroscopy |journal=Nature |volume=420 |issue=6911 |pages=98–102 |year=2002 |pmid=12422222 |doi=10.1038/nature01070 |bibcode=2002Natur.420...98C|s2cid=4422584 }}
{{cite journal |vauthors=Jehle S, Rajagopal P, Bardiaux B, Markovic S, Kühne R, Stout JR, Higman VA, Klevit RE, van Rossum BJ, Oschkinat H |title=Solid-state NMR and SAXS studies provide a structural basis for the activation of alphaB-crystallin oligomers |journal=Nat. Struct. Mol. Biol. |volume=17 |issue=9 |pages=1037–42 |year=2010 |pmid=20802487 |pmc=2957905 |doi=10.1038/nsmb.1891}}
{{cite journal |vauthors=Krabben L, van Rossum BJ, Jehle S, Bocharov E, Lyukmanova EN, Schulga AA, Arseniev A, Hucho F, Oschkinat H |title=Loop 3 of short neurotoxin II is an additional interaction site with membrane-bound nicotinic acetylcholine receptor as detected by solid-state NMR spectroscopy |journal=J. Mol. Biol. |volume=390 |issue=4 |pages=662–71 |year=2009 |pmid=19447114 |doi=10.1016/j.jmb.2009.05.016}}
{{cite journal |vauthors=Nieuwkoop AJ, Franks WT, Rehbein K, Diehl A, Akbey Ü, Engelke F, Emsley L, Pintacuda G, Oschkinat H |title=Sensitivity and resolution of proton detected spectra of a deuterated protein at 40 and 60 kHz magic-angle-spinning |journal=J. Biomol. NMR |volume=61 |issue=2 |pages=161–71 |year=2015 |pmid=25663049 |doi=10.1007/s10858-015-9904-0 |s2cid=27308791 }}
{{cite journal |vauthors=Geiger MA, Orwick-Rydmark M, Märker K, Franks WT, Akhmetzyanov D, Stöppler D, Zinke M, Specker E, Nazaré M, Diehl A, van Rossum BJ, Aussenac F, Prisner T, Akbey Ü, Oschkinat H |title=Temperature dependence of cross-effect dynamic nuclear polarization in rotating solids: advantages of elevated temperatures |journal=Phys Chem Chem Phys |volume=18 |issue=44 |pages=30696–30704 |year=2016 |pmid=27791210 |doi=10.1039/c6cp06154k |bibcode=2016PCCP...1830696G }}
{{cite journal |vauthors=Stöppler D, Song C, van Rossum BJ, Geiger MA, Lang C, Mroginski MA, Jagtap AP, Sigurdsson ST, Matysik J, Hughes J, Oschkinat H |title=Dynamic Nuclear Polarization Provides New Insights into Chromophore Structure in Phytochrome Photoreceptors |journal=Angew. Chem. Int. Ed. Engl. |volume=55 |issue=52 |pages=16017–16020 |year=2016 |pmid=27879035 |doi=10.1002/anie.201608119 }}
{{cite web | url = http://people.embo.org/profile/hartmut-oschkinat | title = Find people in the EMBO Communities | website = EMBO | access-date = 24 January 2017 }}
{{cite web | url = https://vimeo.com/145541139 | title = 2014 Laukien: Hartmut Oschkinat (Leibniz-Institut, Berlin) | website = Vimeo | access-date = 24 January 2017 | date = 2015-11-12 }}
{{cite web | url = https://www.theresonance.com/monday-at-enc-laukien-prize-winners-2014/ | title = Monday at ENC: Laukien Prize Winners 2014 | website = The Resonance | access-date = 24 January 2017 | date = 2014-03-25 }}
{{cite web | url = http://nmrs.iisc.ernet.in/members-hon.htm | title = NMRS Members | website = National Magnetic Resonance Society of India | access-date =27 February 2017}}
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External links
- {{Google scholar id|RXgJTgIAAAAJ}}
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{{DEFAULTSORT:Oschkinat, Hartmut}}
Category:20th-century German chemists
Category:20th-century German biologists