Hepatitis C virus cis-acting replication element

{{Infobox rfam

| Name = Hepatitis C virus (HCV) cis-acting replication element (CRE)

| image = RF00260.jpg

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| caption = Predicted secondary structure and sequence conservation of HepC_CRE

| Symbol = HepC_CRE

| AltSymbols =

| Rfam = RF00260

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| miRBase_family =

| RNA_type = Cis-reg

| Tax_domain = Viruses

| GO =

| SO = {{SO|0000233}}

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| EntrezGene =

| HGNCid =

| OMIM =

| PDB =

| RefSeq =

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| Arm =

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The Hepatitis C virus (HCV) cis-acting replication element (CRE) is an RNA element which is found in the coding region of the RNA-dependent RNA polymerase NS5B. Mutations in this family have been found to cause a blockage in RNA replication and it is thought that both the primary sequence and the structure of this element are crucial for HCV RNA replication.{{cite journal | vauthors = You S, Stump DD, Branch AD, Rice CM | title = A cis-acting replication element in the sequence encoding the NS5B RNA-dependent RNA polymerase is required for hepatitis C virus RNA replication | journal = Journal of Virology | volume = 78 | issue = 3 | pages = 1352–1366 | date = February 2004 | pmid = 14722290 | pmc = 321395 | doi = 10.1128/JVI.78.3.1352-1366.2004 }}