Hi1a
Hi1a molecule is a peptide from the venom of Australian spider Hadronyche infensa (K’gari funnel web spider) which researchers have found, in studies done on mice, to be an acid-sensing ion channel 1a (ASIC1a) inhibitor.{{Cite journal|url=https://pubs.acs.org/doi/10.1021/acs.orglett.1c03112|title=Total Synthesis of the Spider-Venom Peptide Hi1a|first1=Nisharnthi M.|last1=Duggan|first2=Natalie J.|last2=Saez|first3=Daniel|last3=Clayton|first4=Elena|last4=Budusan|first5=Emma E.|last5=Watson|first6=Isaac J.|last6=Tucker|first7=Lachlan D.|last7=Rash|first8=Glenn F.|last8=King|first9=Richard J.|last9=Payne|date=November 5, 2021|journal=Organic Letters|volume=23|issue=21|pages=8375–8379|via=CrossRef|doi=10.1021/acs.orglett.1c03112|pmid=34632783 |url-access=subscription}}{{cite journal | url=https://academic.oup.com/eurheartj/article/45/17/1571/7473189 | doi=10.1093/eurheartj/ehad793 | title=Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarction | date=2024 | last1=Redd | first1=Meredith A. | last2=Yoshikawa | first2=Yusuke | last3=Khan | first3=Nemat | last4=Waqar | first4=Maleeha | last5=Saez | first5=Natalie J. | last6=Outhwaite | first6=Jennifer E. | last7=Russell | first7=Jake S. | last8=Hanna | first8=Amy D. | last9=Chiu | first9=Han S. | last10=Er | first10=Sing Yan | last11=Butcher | first11=Neville J. | last12=Mardon | first12=Karine | last13=Fraser | first13=John F. | last14=Smythe | first14=Mark L. | last15=Rash | first15=Lachlan D. | last16=Thomas | first16=Walter G. | last17=King | first17=Glenn F. | last18=Reichelt | first18=Melissa E. | last19=Palpant | first19=Nathan J. | journal=European Heart Journal | volume=45 | issue=17 | pages=1571–1574 | doi-access=free | hdl=10072/432411 | hdl-access=free }}{{Cite web|url=https://www.uq.edu.au/news/article/2024/10/spider-venom-heart-drug-moves-clinical-trials|title=Spider venom heart drug moves to clinical trials|website=UQ News}} It has cardioprotective properties - preventing heart tissue from degradation during a heart attack{{Cite web|url=https://www.livescience.com/health/medicine-drugs/drug-inspired-by-spider-venom-aims-to-reverse-heart-attack-damage|title=Drug inspired by spider venom aims to reverse heart attack damage|first=Emily|last=Cooke|date=October 16, 2024|website=livescience.com}} and also has a highly neuroprotective effect in case of stroke.{{Cite journal|title=Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a|first1=Irène R.|last1=Chassagnon|first2=Claudia A.|last2=McCarthy|first3=Yanni K.-Y.|last3=Chin|first4=Sandy S.|last4=Pineda|first5=Angelo|last5=Keramidas|first6=Mehdi|last6=Mobli|first7=Vi|last7=Pham|first8=T. Michael|last8=De Silva|first9=Joseph W.|last9=Lynch|first10=Robert E.|last10=Widdop|first11=Lachlan D.|last11=Rash|first12=Glenn F.|last12=King|date=April 4, 2017|journal=Proceedings of the National Academy of Sciences|volume=114|issue=14|pages=3750–3755|doi=10.1073/pnas.1614728114|doi-access=free |pmid=28320941|pmc=5389327|bibcode=2017PNAS..114.3750C }}{{Cite web|url=https://www.bioworld.com/articles/713191-hi1a-demonstrates-neuroprotective-activity-in-eae-mice?v=preview|title=Hi1a demonstrates neuroprotective activity in EAE mice | BioWorld|website=www.bioworld.com}} It has the potential to become the first drug for acute ischemic events that act by preventing cell death.{{cite web |title=Funnel-web spider venom may provide a new drug for heart attacks |url=https://www.health.gov.au/news/mrff-funnel-web-spider-venom-may-provide-a-new-drug-for-heart-attacks |website=Australian Government Department of Health and Aged Care |access-date=22 January 2025 |language=en |date=13 December 2022}}