Howell-Jolly body-like inclusions

Howell-Jolly body-like inclusions (HJBLi) are a hematopathological finding of an inclusion arising from detached DNA nuclear fragment in white blood cells caused by dysplastic granulopoiesis.{{cite book |chapter=Morphology of Blood Cells |title=Blood Cells: A Practical Guide |date=9 June 2006 |pages=61–174 |doi=10.1002/9780470987551.ch3|isbn=978-1-4051-4265-6 }} The inclusion is aptly named for its similar appearance of the Howell–Jolly body in erythrocytes. The term was coined in 1989.{{cite journal |last1=Oehadian |first1=A |last2=Huang |first2=I |last3=Kartikasari |first3=A |last4=Alisjahbana |first4=B |last5=Prihatni |first5=D |title=Howell-Jolly Body-Like Inclusions in Coronavirus Disease 2019 (COVID-19): Possible Novel Findings. |journal=Journal of Blood Medicine |date=2023 |volume=14 |pages=233–238 |doi=10.2147/JBM.S399596 |doi-access=free |pmid=37016662|pmc=10066893 }}

They are most often observed in neutrophils, but can also appear in monocytes, lymphocytes, eosinophils.

They may appear in patients on immunosuppression and antiviral therapies with nucleoside analogs, anticancer chemotherapeutic agents, active COVID-19 infections, HIV/AIDS, and myelodysplastic syndrome.{{cite journal |last1=Tong |first1=YT |last2=Nguyen |first2=ND |last3=Wahed |first3=A |title=Howell-Jolly Body-Like Inclusions in Neutrophils of Patients With Myelodysplastic Syndrome: A Novel Correlation. |journal=Archives of Pathology & Laboratory Medicine |date=January 2019 |volume=143 |issue=1 |pages=112–114 |doi=10.5858/arpa.2017-0328-OA |pmid=30059259|doi-access=free }}