Hsp17 thermometer

{{Short description|RNA element in cynobacteria}}

{{Infobox rfam

| Name = Hsp17 thermometer

| image = RF02358.svg

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| caption = Predicted secondary structure and sequence conservation of PinT small RNA

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| Rfam = RF02358

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| Tax_domain = Bacteria

| GO = {{GO|0009266}}

| SO = {{SO|0005836}}

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In molecular biology, the Hsp17 thermometer is an RNA element (RNA thermometer) found in the 5' UTR of Hsp17 mRNA.{{cite journal|vauthors=Kortmann J, Sczodrok S, Rinnenthal J, Schwalbe H, Narberhaus F | title=Translation on demand by a simple RNA-based thermosensor. | journal=Nucleic Acids Res | year= 2011 | volume= 39 | issue= 7 | pages= 2855–2868 | pmid=21131278 | doi=10.1093/nar/gkq1252 | pmc=3074152 }} Hsp17 is a cyanobacterial heat shock protein belonging to the Hsp20 family.{{cite journal |vauthors=Török Z, Goloubinoff P, Horváth I, Tsvetkova NM, Glatz A, Balogh G, etal | title=Synechocystis HSP17 is an amphitropic protein that stabilizes heat-stressed membranes and binds denatured proteins for subsequent chaperone-mediated refolding. | journal=Proc Natl Acad Sci U S A | year= 2001 | volume= 98 | issue= 6 | pages= 3098–3103 | pmid=11248038 | doi=10.1073/pnas.051619498 | pmc=30613 | doi-access=free }}

At physiological temperature (28 degrees Celsius) the Hsp17 thermometer forms a hairpin structure, preventing translation of Hsp17. Under heat shock conditions the hairpin structure melts and translation takes place.