Humouse

{{Short description|Type of genetically modified mouse}}

{{Refimprove|date=March 2011}}

A humouse is an immunodeficient mouse reconstituted with a human immune system, also generally known as humanised mouse. Although conventional mouse models have allowed for an increased understanding of mammalian immune systems, this knowledge cannot necessarily be directly applied to humans due to biological differences between the two species.{{Cite journal|last=Hughes|first=Christopher C. W.|last2=Mestas|first2=Javier|date=2004-03-01|title=Of Mice and Not Men: Differences between Mouse and Human Immunology|url=http://www.jimmunol.org/content/172/5/2731|journal=The Journal of Immunology|language=en|volume=172|issue=5|pages=2731–2738|doi=10.4049/jimmunol.172.5.2731|issn=1550-6606|pmid=14978070|doi-access=free}}

Humice could theoretically be used as novel pre-clinical models of the human immune system, with uses including assessing vaccine efficacy.{{cite web|title=Baylor Institute for Immunology Research (BIIR): Humouse |url=http://www.baylorhealth.edu/Research/BIIR/humouse.htm |url-status=dead |archiveurl=https://web.archive.org/web/20101215180808/https://baylorhealth.edu/Research/BIIR/humouse.htm |archivedate=2010-12-15 }}