Hydrangea febrifuga
{{Short description|Species of plant}}
{{speciesbox
|image = Dichroa febrifuga Glasgow.jpg
|genus = Hydrangea
|species = febrifuga
|authority = (Lour.) Y.De Smet & Granados
|synonyms={{collapsible list|bullets=true
|title=Synonymy
|Adamia chinensis {{small|Gardner & Champ.}}
|Adamia sylvatica {{small|Meisn.}}
|Callicarpa esquirolii {{small|H.Lév.}}
|Callicarpa leveilleana {{small|Fedde}}
|Cianitis chinensis {{small|Hook.f. & Thomson}}
|Cianitis sylvatica {{small|Reinw.}}
|Dichroa cyanitis {{small|Miq.}}
|Dichroa febrifuga {{small|Lour.}} (basionym)
|Dichroa febrifuga var. glabra {{small|S.Y.Hu}}
|Dichroa henryi {{small|H.Lév.}}
|Dichroa latifolia {{small|Miq.}}
|Dichroa parviflora {{small|Schltr.}}
|Dichroa pentandra {{small|Schltr.}}
|Dichroa philippinensis {{small|Schltr.}}
|Dichroa pubescens {{small|Miq.}}
|Dichroa schumanniana {{small|Schltr.}}
|Dichroa sylvatica {{small|(Reinw.) Mottet}}
|Dichroa thyrsoidea {{small|Elmer}}
|Hydrangea pubescens {{small|Zipp. ex Miq.}}
}}
|synonyms_ref = {{cite web |title=Hydrangea febrifuga (Lour.) Y.De Smet & Granados |url=https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:77152127-1 |website=Plants of the World Online |publisher=Royal Botanic Gardens, Kew |access-date=25 April 2025}}
}}
File:Dichroa febrifuga white.jpg
Hydrangea febrifuga is a flowering plant in the family Hydrangeaceae. It is a subshrub or shrub native to central and southern China, Indochina, Malesia, and New Guinea.
National names
Traditional Chinese medicine
Dichroa febrifuga is an important herb in traditional Chinese medicine, where it is considered one of the 50 fundamental herbs.{{cite web|url=http://www.pfaf.org/database/plants.php?Dichroa+febrifuga |title=Dichroa febrifuga - Plants For A Future database report |access-date=2008-02-05 }} The alkaloids febrifugine and isofebrifugine are believed to be responsible for its antimalarial effects.{{cite journal | pmc = 2072810 | doi = 10.1016/j.bmcl.2006.01.009 | title = Synthesis and evaluation of febrifugine analogues as potential antimalarial agents | year = 2006 | last1 = Zhu | first1 = Shuren | last2 = Meng | first2 = Li | last3 = Zhang | first3 = Quan | last4 = Wei | first4 = Lai | journal = Bioorganic & Medicinal Chemistry Letters | volume = 16 | issue = 7 | pages = 1854–1858 | pmid=16434194}} In traditional preparations, it is used in conjunction with other plants such as Glycyrrhiza glabra (licorice), Ziziphus jujuba and Zingiber officinale (ginger).{{cite journal | pmc = 3059462 | doi = 10.1186/1475-2875-10-S1-S4 | title = Whole plant extracts versus single compounds for the treatment of malaria: Synergy and positive interactions | year = 2011 | last1 = Rasoanaivo | first1 = Philippe | last2 = Wright | first2 = Colin W | last3 = Willcox | first3 = Merlin L | last4 = Gilbert | first4 = Ben | journal = Malaria Journal | volume = 10 | pages = S4 | pmid = 21411015 | issue = Suppl 1 | doi-access = free }}
Potential drug against autoimmune disease
Halofuginone, sold under the brand name Halocur, is a coccidiostat used in veterinary medicine. It is a synthetic halogenated derivative of febrifugine, a natural quinazolinone alkaloid which can be found in dichroa febrifuga.{{cite web | url = http://www.cancer.gov/drugdictionary/?CdrID=38485 | title = Halofuginone hydrobromide | work = NCI Drug Dictionary | publisher = National Cancer Institute, National Institutes of Health, U.S. Department of Health and Human Services }}
Halofuginone inhibits the development of T helper 17 cells, immune cells that play an important role in autoimmune disease, but it does not affect other kinds of T cells which are involved in normal immune function.{{cite journal | vauthors = Sundrud MS, Koralov SB, Feuerer M, Calado DP, Kozhaya AE, Rhule-Smith A, Lefebvre RE, Unutmaz D, Mazitschek R, Waldner H, Whitman M, Keller T, Rao A | display-authors = 6 | title = Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response | journal = Science | volume = 324 | issue = 5932 | pages = 1334–8 | date = June 2009 | pmid = 19498172 | pmc = 2803727 | doi = 10.1126/science.1172638 | bibcode = 2009Sci...324.1334S }} Halofuginone therefore has potential for the treatment of autoimmune disorders.{{cite journal | vauthors = Sundrud MS, Koralov SB, Feuerer M, Calado DP, Kozhaya AE, Rhule-Smith A, Lefebvre RE, Unutmaz D, Mazitschek R, Waldner H, Whitman M, Keller T, Rao A | title = Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response | journal = Science | volume = 324 | issue = 5932 | pages = 1334–8 | date = June 2009 | pmid = 19498172 | pmc = 2803727 | doi = 10.1126/science.1172638 | bibcode = 2009Sci...324.1334S}}
- {{cite press release |date=4 June 2009 |title=A new lead for autoimmune disease |website=EurekAlert! |url=http://www.eurekalert.org/pub_releases/2009-06/chb-anl060109.php}}
References
{{Reflist}}
External links
{{Commons}}
- [https://images.google.com/images?as_q=%22Dichroa+febrifuga%22&num=20&btnG=Google+Search&imgsafe=active Dichroa febrifuga (Google Images)]
- [https://archive.today/20121128180106/http://211.114.21.20/tropicalplant/html/print.jsp?rno=724 Dichroa febrifuga Lour ASEAN Tropical Plant DB]
{{Taxonbar|from=Q42688896}}
Category:Flora of North-Central China
Category:Flora of South-Central China
Category:Flora of Southeast China
Category:Medicinal plants of Asia
Category:Plants used in traditional Chinese medicine
Category:Plants described in 1790
Category:Taxa named by João de Loureiro
{{Cornales-stub}}
{{medicinal-plant-stub}}