Hypoalphalipoproteinemia

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| name = Hypoalphalipoproteinemia

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| image = Autosomal dominant - en.svg

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| caption = Hypoalphalipoproteinemia has an autosomal dominant pattern of inheritance.

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Hypoalphalipoproteinemia is a high-density lipoprotein deficiency, inherited in an autosomal dominant manner.{{OMIM|604091}}

It can be associated with LDL receptor.{{cite journal |vauthors=Pisciotta L, Calabresi L, Lupattelli G, etal |title=Combined monogenic hypercholesterolemia and hypoalphalipoproteinemia caused by mutations in LDL-R and LCAT genes |journal=Atherosclerosis |volume=182 |issue=1 |pages=153–9 |date=September 2005 |pmid=16115486 |doi=10.1016/j.atherosclerosis.2005.01.048 }}

Associated regions and genes include:

class="wikitable"
Name ! OMIM ! Locus ! Candidates
HDLCQ1 | {{OMIM|606613	none}} | 9p | ABCA1 (Tangier disease){{cite journal |vauthors=Soro-Paavonen A, Naukkarinen J, Lee-Rueckert M, etal |title=Common ABCA1 variants, HDL levels, and cellular cholesterol efflux in subjects with familial low HDL |journal=J. Lipid Res. |volume=48 |issue=6 |pages=1409–16 |date=June 2007 |pmid=17372331 |doi=10.1194/jlr.P600012-JLR200 |doi-access=free }}
HDLCQ2 | {{OMIM|607053	none}} | 8q23
HDLCQ3 | {{OMIM|607687	none}} | 16q24.1 | Lecithin cholesterol acyltransferase deficiency (LCAT)
HDLCQ4 | {{OMIM|610239	none}} | 4q32
HDLD3 | {{OMIM|605201	none}} | 11q23.3 | APOA1

Niacin is sometimes prescribed to raise HDL levels.{{cn|date=July 2022}}