Hypothalamic obesity
{{Short description|Medical condition}}
Hypothalamic obesity (abbreviated HO or HyOb) is a rare condition that can be congenital or acquired. Congenital causes include Prader-Willi syndrome and mutations of LEP (leptin gene), LEPR, POMC, MC4R, and CART. It can also result from injuries to the hypothalamus either from trauma, therapeutic radiation, brain surgery, and especially craniopharyngioma and its treatments. Possible treatments include bariatric surgery and melanocortin 4 receptor agonists such as setmelanotide.{{cite journal |last1=Dimitri |first1=Paul |title=Treatment of Acquired Hypothalamic Obesity: Now and the Future |journal=Frontiers in Endocrinology |date=6 April 2022 |volume=13 |pages=846880 |doi=10.3389/fendo.2022.846880 |pmid=35464063 |pmc=9019363 |issn=1664-2392 |doi-access=free }}{{cite journal |last1=Bereket |first1=A. |last2=Kiess |first2=W. |last3=Lustig |first3=R. H. |last4=Muller |first4=H. L. |last5=Goldstone |first5=A. P. |last6=Weiss |first6=R. |last7=Yavuz |first7=Y. |last8=Hochberg |first8=Z. |title=Hypothalamic obesity in children |journal=Obesity Reviews |date=September 2012 |volume=13 |issue=9 |pages=780–798 |doi=10.1111/j.1467-789X.2012.01004.x |pmid=22577758 |s2cid=9550333 }}{{cite journal |last1=Abuzzahab |first1=M. Jennifer |last2=Roth |first2=Christian L. |last3=Shoemaker |first3=Ashley H. |title=Hypothalamic Obesity: Prologue and Promise |journal=Hormone Research in Paediatrics |date=2019 |volume=91 |issue=2 |pages=128–136 |doi=10.1159/000496564|pmid=30884480 |s2cid=83460590 |doi-access=free }}{{cite journal |last1=Kim |first1=Ja Hye |last2=Choi |first2=Jin-Ho |title=Pathophysiology and clinical characteristics of hypothalamic obesity in children and adolescents |journal=Annals of Pediatric Endocrinology & Metabolism |date=December 2013 |volume=18 |issue=4 |pages=161–167 |doi=10.6065/apem.2013.18.4.161 |pmid=24904871 |pmc=4027083 |issn=2287-1012}}