ICAM5

{{Short description|Protein-coding gene in the species Homo sapiens}}

Intercellular adhesion molecule 5 is a protein that in humans is encoded by the ICAM5 gene.{{cite journal |vauthors=Mizuno T, Yoshihara Y, Inazawa J, Kagamiyama H, Mori K | title = cDNA cloning and chromosomal localization of the human telencephalin and its distinctive interaction with lymphocyte function-associated antigen-1 | journal = J Biol Chem | volume = 272 | issue = 2 | pages = 1156–63 |date=Feb 1997 | pmid = 8995416 | doi =10.1074/jbc.272.2.1156 | doi-access = free }}{{cite journal |vauthors=Kilgannon P, Turner T, Meyer J, Wisdom W, Gallatin WM | title = Mapping of the ICAM-5 (telencephalin) gene, a neuronal member of the ICAM family, to a location between ICAM-1 and ICAM-3 on human chromosome 19p13.2 | journal = Genomics | volume = 54 | issue = 2 | pages = 328–30 |date=Jan 1999 | pmid = 9828136 | doi = 10.1006/geno.1998.5565 }}{{cite web | title = Entrez Gene: ICAM5 intercellular adhesion molecule 5, telencephalin| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7087}}

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases.

Studies mentioned a role for ICAM5 in cell adhesion and cell signalling and dysregulation and disfunction of it will increase the risk of breast cancer.{{Cite journal |last=Kammerer |first=Stefan |last2=Roth |first2=Richard B. |last3=Reneland |first3=Richard |last4=Marnellos |first4=George |last5=Hoyal |first5=Carolyn R. |last6=Markward |first6=Nathan J. |last7=Ebner |first7=Florian |last8=Kiechle |first8=Marion |last9=Schwarz-Boeger |first9=Ulrike |last10=Griffiths |first10=Lyn R. |last11=Ulbrich |first11=Christian |last12=Chrobok |first12=Korbinian |last13=Forster |first13=Gerhard |last14=Praetorius |first14=Georg M. |last15=Meyer |first15=Peter |date=2004-12-16 |title=Large-Scale Association Study Identifies ICAM Gene Region as Breast and Prostate Cancer Susceptibility Locus |url=https://aacrjournals.org/cancerres/article/64/24/8906/512116/Large-Scale-Association-Study-Identifies-ICAM-Gene |journal=Cancer Research |volume=64 |issue=24 |pages=8906–8910 |doi=10.1158/0008-5472.CAN-04-1788 |issn=0008-5472}} Study of the association between polymorphisms and breast cancer has been shown that ICAM5 rs1056538 and ICAM5 rs281439 variants might contribute the most in the development of breast cancer.{{Cite journal |last=Liu |first=Lin |last2=Sun |first2=Meili |last3=Song |first3=Degang |last4=Wang |first4=Zhehai |date=2013-02-01 |title=The genetic polymorphisms of intercellular cell adhesion molecules and breast cancer susceptibility: a meta-analysis |url=https://link.springer.com/article/10.1007/s11033-012-2241-4 |journal=Molecular Biology Reports |language=en |volume=40 |issue=2 |pages=1855–1860 |doi=10.1007/s11033-012-2241-4 |issn=1573-4978}}

Interactions

ICAM5 has been shown to interact with PSEN1.{{cite journal |doi=10.1016/S0896-6273(01)00512-8 |last=Annaert |first=W G |author2=Esselens C |author3=Baert V |author4=Boeve C |author5=Snellings G |author6=Cupers P |author7=Craessaerts K |author8=De Strooper B |date=Nov 2001 |title=Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins |journal=Neuron |volume=32 |issue=4 |pages=579–89 | issn = 0896-6273| pmid = 11719200 |s2cid=2096602 |doi-access=free }}

References

{{cite journal |vauthors=Yoshihara Y, Mori K |title=Telencephalin: a neuronal area code molecule? |journal=Neurosci. Res. |volume=21 |issue= 2 |pages= 119–24 |year= 1995 |pmid= 7724062 |doi=10.1016/0168-0102(94)90153-8 |s2cid=19931440 }}
{{cite journal |vauthors=Hayflick JS, Kilgannon P, Gallatin WM |title=The intercellular adhesion molecule (ICAM) family of proteins. New members and novel functions. |journal=Immunol. Res. |volume=17 |issue= 3 |pages= 313–27 |year= 1998 |pmid= 9638475 |doi=10.1007/BF02786454 |s2cid=19901365 }}
{{cite journal |vauthors=Benson DL, Yoshihara Y, Mori K |title=Polarized distribution and cell type-specific localization of telencephalin, an intercellular adhesion molecule. |journal=J. Neurosci. Res. |volume=52 |issue= 1 |pages= 43–53 |year= 1998 |pmid= 9556028 |doi=10.1002/(SICI)1097-4547(19980401)52:1<43::AID-JNR5>3.0.CO;2-K |s2cid=22675478 |doi-access=free }}
{{cite journal |vauthors=Rieckmann P, Turner T, Kligannon P, Steinhoff BJ |title=Telencephalin as an indicator for temporal-lobe dysfunction. |journal=Lancet |volume=352 |issue= 9125 |pages= 370–1 |year= 1998 |pmid= 9717930 |doi=10.1016/S0140-6736(05)60469-2 |s2cid=6255738 }}
{{cite journal |vauthors=Arii N, Mizuguchi M, Mori K, Takashima S |title=Development of telencephalin in the human cerebrum. |journal=Microsc. Res. Tech. |volume=46 |issue= 1 |pages= 18–23 |year= 1999 |pmid= 10402269 |doi= 10.1002/(SICI)1097-0029(19990701)46:1<18::AID-JEMT2>3.0.CO;2-G |s2cid=22133468 }}
{{cite journal |vauthors=Mizuno T, Yoshihara Y, Kagamiyama H, etal |title=Neuronal adhesion molecule telencephalin induces rapid cell spreading of microglia. |journal=Brain Res. |volume=849 |issue= 1–2 |pages= 58–66 |year= 2000 |pmid= 10592287 |doi=10.1016/S0006-8993(99)01984-8 |s2cid=353053 }}
{{cite journal |vauthors=Tian L, Kilgannon P, Yoshihara Y, etal |title=Binding of T lymphocytes to hippocampal neurons through ICAM-5 (telencephalin) and characterization of its interaction with the leukocyte integrin CD11a/CD18. |journal=Eur. J. Immunol. |volume=30 |issue= 3 |pages= 810–8 |year= 2000 |pmid= 10741396 |doi= 10.1002/1521-4141(200003)30:3<810::AID-IMMU810>3.0.CO;2-X |doi-access= free }}
{{cite journal |vauthors=Tian L, Nyman H, Kilgannon P, etal |title=Intercellular adhesion molecule-5 induces dendritic outgrowth by homophilic adhesion. |journal=J. Cell Biol. |volume=150 |issue= 1 |pages= 243–52 |year= 2000 |pmid= 10893271 |doi=10.1083/jcb.150.1.243 | pmc=2185561 }}
{{cite journal |vauthors=Annaert WG, Esselens C, Baert V, etal |title=Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins. |journal=Neuron |volume=32 |issue= 4 |pages= 579–89 |year= 2002 |pmid= 11719200 |doi=10.1016/S0896-6273(01)00512-8 |s2cid=2096602 |doi-access=free }}
{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
{{cite journal |vauthors=Gevaert K, Goethals M, Martens L, etal |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 |s2cid=23783563 }}
{{cite journal |vauthors=Brill LM, Salomon AR, Ficarro SB, etal |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763–72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d }}
{{cite journal |vauthors=Cox DG, Hankinson SE, Hunter DJ |title=Polymorphisms in the ICAM gene locus are not associated with breast cancer Risk. |journal=Cancer Epidemiol. Biomarkers Prev. |volume=15 |issue= 1 |pages= 178–9 |year= 2006 |pmid= 16434609 |doi= 10.1158/1055-9965.EPI-05-0790 |doi-access= free }}

ICAM5

Interactions

References

Further reading