IER3

{{Short description|Protein-coding gene in the species Homo sapiens}}

Radiation-inducible immediate-early gene IEX-1 is a protein that in humans is encoded by the IER3 gene.{{cite journal |vauthors=Kondratyev AD, Chung KN, Jung MO | title = Identification and characterization of a radiation-inducible glycosylated human early-response gene | journal = Cancer Res | volume = 56 | issue = 7 | pages = 1498–502 |date=May 1996 | pmid = 8603392 }}{{cite journal |vauthors=Wu MX, Ao Z, Prasad KV, Wu R, Schlossman SF | title = IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survival | journal = Science | volume = 281 | issue = 5379 | pages = 998–1001 |date=Aug 1998 | pmid = 9703517 | doi =10.1126/science.281.5379.998 | bibcode = 1998Sci...281..998W }}

This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein.{{cite web | title = Entrez Gene: IER3 immediate early response 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8870}}

References

{{cite journal | author=Wu MX |title=Roles of the stress-induced gene IEX-1 in regulation of cell death and oncogenesis. |journal=Apoptosis |volume=8 |issue= 1 |pages= 11–8 |year= 2003 |pmid= 12510147 |doi=10.1023/A:1021688600370 |s2cid=20935065 }}
{{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
{{cite journal |vauthors=Schäfer H, Trauzold A, Siegel EG, etal |title=PRG1: a novel early-response gene transcriptionally induced by pituitary adenylate cyclase activating polypeptide in a pancreatic carcinoma cell line. |journal=Cancer Res. |volume=56 |issue= 11 |pages= 2641–8 |year= 1996 |pmid= 8653710 }}
{{cite journal |vauthors=Pietzsch A, Büchler C, Aslanidis C, Schmitz G |title=Identification and characterization of a novel monocyte/macrophage differentiation-dependent gene that is responsive to lipopolysaccharide, ceramide, and lysophosphatidylcholine. |journal=Biochem. Biophys. Res. Commun. |volume=235 |issue= 1 |pages= 4–9 |year= 1997 |pmid= 9196025 |doi= 10.1006/bbrc.1997.6715 }}
{{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
{{cite journal |vauthors=Pietzsch A, Büchler C, Schmitz G |title=Genomic organization, promoter cloning, and chromosomal localization of the Dif-2 gene. |journal=Biochem. Biophys. Res. Commun. |volume=245 |issue= 3 |pages= 651–7 |year= 1998 |pmid= 9588170 |doi= 10.1006/bbrc.1998.8500 }}
{{cite journal |vauthors=Schäfer H, Diebel J, Arlt A, etal |title=The promoter of human p22/PACAP response gene 1 (PRG1) contains functional binding sites for the p53 tumor suppressor and for NFkappaB. |journal=FEBS Lett. |volume=436 |issue= 2 |pages= 139–43 |year= 1998 |pmid= 9781666 |doi=10.1016/S0014-5793(98)01109-0 |s2cid=28479652 |doi-access= }}
{{cite journal |vauthors=Kobayashi T, Pittelkow MR, Warner GM, etal |title=Regulation of a novel immediate early response gene, IEX-1, in keratinocytes by 1alpha,25-dihydroxyvitamin D3. |journal=Biochem. Biophys. Res. Commun. |volume=251 |issue= 3 |pages= 868–73 |year= 1998 |pmid= 9791001 |doi= 10.1006/bbrc.1998.9556 }}
{{cite journal |vauthors=Kumar R, Kobayashi T, Warner GM, etal |title=A novel immediate early response gene, IEX-1, is induced by ultraviolet radiation in human keratinocytes. |journal=Biochem. Biophys. Res. Commun. |volume=253 |issue= 2 |pages= 336–41 |year= 1999 |pmid= 9878538 |doi= 10.1006/bbrc.1998.9692 }}
{{cite journal |vauthors=Schäfer H, Arlt A, Trauzold A, etal |title=The putative apoptosis inhibitor IEX-1L is a mutant nonspliced variant of p22(PRG1/IEX-1) and is not expressed in vivo. |journal=Biochem. Biophys. Res. Commun. |volume=262 |issue= 1 |pages= 139–45 |year= 1999 |pmid= 10448082 |doi= 10.1006/bbrc.1999.1131 }}
{{cite journal |vauthors=Feldmann KA, Pittelkow MR, Roche PC, etal |title=Expression of an immediate early gene, IEX-1, in human tissues. |journal=Histochem. Cell Biol. |volume=115 |issue= 6 |pages= 489–97 |year= 2001 |pmid= 11455449 |doi= 10.1007/s004180100284 |s2cid=24380294 }}
{{cite journal |vauthors=Zhang Y, Schlossman SF, Edwards RA, etal |title=Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 2 |pages= 878–83 |year= 2002 |pmid= 11782530 |doi= 10.1073/pnas.022326699 | pmc=117399 |bibcode=2002PNAS...99..878Z |doi-access=free }}
{{cite journal |vauthors=Im HJ, Pittelkow MR, Kumar R |title=Divergent regulation of the growth-promoting gene IEX-1 by the p53 tumor suppressor and Sp1. |journal=J. Biol. Chem. |volume=277 |issue= 17 |pages= 14612–21 |year= 2002 |pmid= 11844788 | pmc=2895739 |doi= 10.1074/jbc.M109414200 |doi-access=free }}
{{cite journal |vauthors=Ohki R, Yamamoto K, Mano H, etal |title=Identification of mechanically induced genes in human monocytic cells by DNA microarrays. |journal=J. Hypertens. |volume=20 |issue= 4 |pages= 685–91 |year= 2002 |pmid= 11910304 |doi=10.1097/00004872-200204000-00026 |s2cid=34968458 }}
{{cite journal |vauthors=Im HJ, Craig TA, Pittelkow MR, Kumar R |title=Characterization of a novel hexameric repeat DNA sequence in the promoter of the immediate early gene, IEX-1, that mediates 1alpha,25-dihydroxyvitamin D(3)-associated IEX-1 gene repression. |journal=Oncogene |volume=21 |issue= 23 |pages= 3706–14 |year= 2002 |pmid= 12032839 |doi= 10.1038/sj.onc.1205450 |s2cid=38132204 |doi-access= }}
{{cite journal |vauthors=Garcia J, Ye Y, Arranz V, etal |title=IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation. |journal=EMBO J. |volume=21 |issue= 19 |pages= 5151–63 |year= 2002 |pmid= 12356731 |doi=10.1093/emboj/cdf488 | pmc=129026 }}
{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}

IER3

References

Further reading