IFITM3
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Interferon-induced transmembrane protein 3 (IFITM3) is a protein that in humans is encoded by the IFITM3 gene.{{cite journal |vauthors=Lewin AR, Reid LE, McMahon M, Stark GR, Kerr IM | title = Molecular analysis of a human interferon-inducible gene family | journal = Eur J Biochem | volume = 199 | issue = 2 | pages = 417–423 |date=Aug 1991 | pmid = 1906403 | doi =10.1111/j.1432-1033.1991.tb16139.x | doi-access = free }}{{cite journal |vauthors=Tanaka SS, Yamaguchi YL, Tsoi B, Lickert H, Tam PP | title = IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion | journal = Dev Cell | volume = 9 | issue = 6 | pages = 745–756 |date=Dec 2005 | pmid = 16326387 | doi = 10.1016/j.devcel.2005.10.010 | doi-access = free }}{{cite web | title = Entrez Gene: IFITM3 interferon induced transmembrane protein 3 (1-8U)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10410}} It plays a critical role in the immune system's defense against Swine Flu, where heightened levels of IFITM3 keep viral levels low, and the removal of IFITM3 allows the virus to multiply unchecked.{{cite web|url=https://www.telegraph.co.uk/health/swine-flu/6834606/Natural-swine-flu-defence-found.html|archive-url=https://web.archive.org/web/20091220004257/http://www.telegraph.co.uk/health/swine-flu/6834606/Natural-swine-flu-defence-found.html|url-status=dead|archive-date=December 20, 2009|title=Natural swine flu defence found}} This observation has been further advanced by a recent study from Paul Kellam's lab that shows that a single nucleotide polymorphism in the human IFITM3 gene purported to increase influenza susceptibility is overrepresented in people hospitalised with pandemic H1N1.{{cite journal |author=Everitt A.R.|title=IFITM3 restricts the morbidity and mortality associated with influenza. |journal=Nature |volume= 484|date=March 2012 |pmid=22446628 |doi=10.1038/nature10921 |issue=7395 |pages=519–23|display-authors=etal|pmc=3648786 |bibcode=2012Natur.484..519. }} The prevalence of this mutation is thought to be approximately 1/400 in European populations.{{cite news|url=https://www.bbc.co.uk/news/health-17474197|title=Gene flaw linked to serious flu risk|work=BBC News|date=25 March 2012}}
References
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Further reading
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- {{cite journal |vauthors=Vaarala MH, Porvari K, Kyllönen A, Vihko P |title=Differentially expressed genes in two LNCaP prostate cancer cell lines reflecting changes during prostate cancer progression |journal=Lab. Invest. |volume=80 |issue= 8 |pages= 1259–1268 |year= 2000 |pmid= 10950117 |doi=10.1038/labinvest.3780134 |doi-access=free }}
- {{cite journal |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–1795 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000 | pmc=310948 }}
- {{cite journal | author=Simpson JC |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–292 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 | pmc=1083732 |name-list-style=vanc| author2=Wellenreuther R | author3=Poustka A | display-authors=3 | last4=Pepperkok | first4=R | last5=Wiemann | first5=S }}
- {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
- {{cite journal | author=Wiemann S |title=From ORFeome to biology: a functional genomics pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–2144 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930 |name-list-style=vanc| author2=Arlt D | author3=Huber W | display-authors=3 | last4=Wellenreuther | first4=R | last5=Schleeger | first5=S | last6=Mehrle | first6=A | last7=Bechtel | first7=S | last8=Sauermann | first8=M | last9=Korf | first9=U }}
- {{cite journal | author=Kimura K |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |name-list-style=vanc| author2=Wakamatsu A | author3=Suzuki Y | display-authors=3 | last4=Ota | first4=T | last5=Nishikawa | first5=T | last6=Yamashita | first6=R | last7=Yamamoto | first7=J | last8=Sekine | first8=M | last9=Tsuritani | first9=K }}
- {{cite journal | author=Mehrle A |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–D418 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 |name-list-style=vanc| author2=Rosenfelder H | author3=Schupp I | display-authors=3 | last4=Del Val | first4=C | last5=Arlt | first5=D | last6=Hahne | first6=F | last7=Bechtel | first7=S | last8=Simpson | first8=J | last9=Hofmann | first9=O }}
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