IFNAR1

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for type I interferons, including interferon-alpha, -beta, and -lambda. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor.

IFNAR1 has been shown to interact with:

• PRMT1,{{cite journal | vauthors = Abramovich C, Yakobson B, Chebath J, Revel M | title = A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor | journal = EMBO J. | volume = 16 | issue = 2 | pages = 260–6 | date = Jan 1997 | pmid = 9029147 | pmc = 1169633 | doi = 10.1093/emboj/16.2.260 }}
• STAT2,{{cite journal | vauthors = Li X, Leung S, Kerr IM, Stark GR | title = Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling | journal = Mol. Cell. Biol. | volume = 17 | issue = 4 | pages = 2048–56 | date = Apr 1997 | pmid = 9121453 | pmc = 232052 | doi = 10.1128/mcb.17.4.2048}}{{cite journal | vauthors = Uddin S, Chamdin A, Platanias LC | title = Interaction of the transcriptional activator Stat-2 with the type I interferon receptor | journal = J. Biol. Chem. | volume = 270 | issue = 42 | pages = 24627–30 | date = Oct 1995 | pmid = 7559568 | doi = 10.1074/jbc.270.42.24627| doi-access = free }}{{cite journal | vauthors = Yan H, Krishnan K, Greenlund AC, Gupta S, Lim JT, Schreiber RD, Schindler CW, Krolewski JJ | title = Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein | journal = EMBO J. | volume = 15 | issue = 5 | pages = 1064–74 | date = Mar 1996 | pmid = 8605876 | pmc = 450004 | doi = 10.1002/j.1460-2075.1996.tb00444.x}} and
• Tyrosine kinase 2.{{cite journal | vauthors = Richter MF, Duménil G, Uzé G, Fellous M, Pellegrini S | title = Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1 | journal = J. Biol. Chem. | volume = 273 | issue = 38 | pages = 24723–9 | date = Sep 1998 | pmid = 9733772 | doi = 10.1074/jbc.273.38.24723| doi-access = free }}{{cite journal | vauthors = Kumar KG, Varghese B, Banerjee A, Baker DP, Constantinescu SN, Pellegrini S, Fuchs SY | title = Basal ubiquitin-independent internalization of interferon alpha receptor is prevented by Tyk2-mediated masking of a linear endocytic motif | journal = J. Biol. Chem. | volume = 283 | issue = 27 | pages = 18566–72 | date = Jul 2008 | pmid = 18474601 | pmc = 2441555 | doi = 10.1074/jbc.M800991200 | doi-access = free }}

{{reflist}}

{{refbegin | 2}}

• {{cite journal | vauthors = Bürglin TR, Barnes TM | title = Introns in sequence tags | journal = Nature | volume = 357 | issue = 6377 | pages = 367–8 | year = 1992 | pmid = 1350660 | doi = 10.1038/357367a0 | bibcode = 1992Natur.357..367B | s2cid = 2693051 | doi-access = free }}
• {{cite journal |author=Qiujing Yu |author2=Yuliya V Katlinskaya | title = DNA-Damage-Induced Type I Interferon Promotes Senescence and Inhibits Stem Cell Function | journal = Cell Reports | year = 2015 | doi = 10.1016/j.celrep.2015.03.069 |display-authors=etal | volume=11 | issue = 5 | pages=785–797 | pmid=25921537 | pmc=4426031}}
• {{cite journal | vauthors = Lutfalla G, Gardiner K, Proudhon D, Vielh E, Uzé G | title = The structure of the human interferon alpha/beta receptor gene | journal = J. Biol. Chem. | volume = 267 | issue = 4 | pages = 2802–9 | year = 1992 | doi = 10.1016/S0021-9258(18)45950-9 | pmid = 1370833 | doi-access = free }}
• {{cite journal | vauthors = Flores I, Mariano TM, Pestka S | title = Human interferon omega (omega) binds to the alpha/beta receptor | journal = J. Biol. Chem. | volume = 266 | issue = 30 | pages = 19875–7 | year = 1991 | doi = 10.1016/S0021-9258(18)54862-6 | pmid = 1834641 | doi-access = free }}
• {{cite journal | vauthors = Lutfalla G, Roeckel N, Mogensen KE, Mattei MG, Uzé G | title = Assignment of the human interferon-alpha receptor gene to chromosome 21q22.1 by in situ hybridization | journal = J. Interferon Res. | volume = 10 | issue = 5 | pages = 515–7 | year = 1990 | pmid = 2148760 | doi = 10.1089/jir.1990.10.515 }}
• {{cite journal | vauthors = Uzé G, Lutfalla G, Gresser I | title = Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA | journal = Cell | volume = 60 | issue = 2 | pages = 225–34 | year = 1990 | pmid = 2153461 | doi = 10.1016/0092-8674(90)90738-Z | s2cid = 54409221 }}
• {{cite journal | vauthors = Colamonici O, Yan H, Domanski P, Handa R, Smalley D, Mullersman J, Witte M, Krishnan K, Krolewski J | title = Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase | journal = Mol. Cell. Biol. | volume = 14 | issue = 12 | pages = 8133–42 | year = 1994 | pmid = 7526154 | pmc = 359352 | doi = 10.1128/mcb.14.12.8133}}
• {{cite journal | vauthors = Uddin S, Chamdin A, Platanias LC | title = Interaction of the transcriptional activator Stat-2 with the type I interferon receptor | journal = J. Biol. Chem. | volume = 270 | issue = 42 | pages = 24627–30 | year = 1995 | pmid = 7559568 | doi = 10.1074/jbc.270.42.24627 | doi-access = free }}
• {{cite journal | vauthors = Domanski P, Witte M, Kellum M, Rubinstein M, Hackett R, Pitha P, Colamonici OR | title = Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling | journal = J. Biol. Chem. | volume = 270 | issue = 37 | pages = 21606–11 | year = 1995 | pmid = 7665574 | doi = 10.1074/jbc.270.37.21606 | doi-access = free }}
• {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
• {{cite journal | vauthors = Yan H, Krishnan K, Greenlund AC, Gupta S, Lim JT, Schreiber RD, Schindler CW, Krolewski JJ | title = Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein | journal = EMBO J. | volume = 15 | issue = 5 | pages = 1064–74 | year = 1996 | pmid = 8605876 | pmc = 450004 | doi = 10.1002/j.1460-2075.1996.tb00444.x}}
• {{cite journal | vauthors = Yang CH, Shi W, Basu L, Murti A, Constantinescu SN, Blatt L, Croze E, Mullersman JE, Pfeffer LM | title = Direct association of STAT3 with the IFNAR-1 chain of the human type I interferon receptor | journal = J. Biol. Chem. | volume = 271 | issue = 14 | pages = 8057–61 | year = 1996 | pmid = 8626489 | doi = 10.1074/jbc.271.14.8057 | doi-access = free }}
• {{cite journal | vauthors = Abramovich C, Yakobson B, Chebath J, Revel M | title = A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor | journal = EMBO J. | volume = 16 | issue = 2 | pages = 260–6 | year = 1997 | pmid = 9029147 | pmc = 1169633 | doi = 10.1093/emboj/16.2.260 }}
• {{cite journal | vauthors = Eantuzzi L, Eid P, Malorni W, Rainaldi G, Gauzzi MC, Pellegrini S, Belardelli F, Gessani S | title = Post-translational up-regulation of the cell surface-associated alpha component of the human type I interferon receptor during differentiation of peripheral blood monocytes: role in the biological response to type I interferon | journal = Eur. J. Immunol. | volume = 27 | issue = 5 | pages = 1075–81 | year = 1997 | pmid = 9174595 | doi = 10.1002/eji.1830270506 | s2cid = 6569287 }}
• {{cite journal | vauthors = Gessani S, Borghi P, Fantuzzi L, Varano B, Conti L, Puddu P, Belardelli F | title = Induction of cytokines by HIV-1 and its gp120 protein in human peripheral blood monocyte/macrophages and modulation of cytokine response during differentiation | journal = J. Leukoc. Biol. | volume = 62 | issue = 1 | pages = 49–53 | year = 1997 | pmid = 9225992 | doi = 10.1002/jlb.62.1.49| s2cid = 31546644 | doi-access = free }}
• {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
• {{cite journal | vauthors = Krishnan K, Singh B, Krolewski JJ | title = Identification of amino acid residues critical for the Src-homology 2 domain-dependent docking of Stat2 to the interferon alpha receptor | journal = J. Biol. Chem. | volume = 273 | issue = 31 | pages = 19495–501 | year = 1998 | pmid = 9677371 | doi = 10.1074/jbc.273.31.19495 | doi-access = free }}
• {{cite journal | vauthors = Richter MF, Duménil G, Uzé G, Fellous M, Pellegrini S | title = Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1 | journal = J. Biol. Chem. | volume = 273 | issue = 38 | pages = 24723–9 | year = 1998 | pmid = 9733772 | doi = 10.1074/jbc.273.38.24723 | doi-access = free }}
• {{cite journal | vauthors = Rani MR, Leaman DW, Han Y, Leung S, Croze E, Fish EN, Wolfman A, Ransohoff RM | title = Catalytically active TYK2 is essential for interferon-beta-mediated phosphorylation of STAT3 and interferon-alpha receptor-1 (IFNAR-1) but not for activation of phosphoinositol 3-kinase | journal = J. Biol. Chem. | volume = 274 | issue = 45 | pages = 32507–11 | year = 1999 | pmid = 10542297 | doi = 10.1074/jbc.274.45.32507 | doi-access = free }}

{{refend}}

{{Cytokine receptors}}

{{Portal bar|Biology}}

{{gene-21-stub}}