IFNAR2

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene.{{cite web | title = Entrez Gene: IFNAR2 interferon (alpha, beta and omega) receptor 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3455}}

IFNAR2 has been shown to interact with:

• GNB2L1,{{cite journal | vauthors = Croze E, Usacheva A, Asarnow D, Minshall RD, Perez HD, Colamonici O | title = Receptor for activated C-kinase (RACK-1), a WD motif-containing protein, specifically associates with the human type I IFN receptor | journal = J. Immunol. | volume = 165 | issue = 9 | pages = 5127–32 | date = November 2000 | pmid = 11046044 | doi = 10.4049/jimmunol.165.9.5127| doi-access = free }}
• IFNA2,{{cite journal | vauthors = Piehler J, Schreiber G | title = Biophysical analysis of the interaction of human ifnar2 expressed in E. coli with IFNalpha2 | journal = J. Mol. Biol. | volume = 289 | issue = 1 | pages = 57–67 | date = May 1999 | pmid = 10339405 | doi = 10.1006/jmbi.1999.2726 }}
• STAT1,{{cite journal | vauthors = Usacheva A, Smith R, Minshall R, Baida G, Seng S, Croze E, Colamonici O | title = The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor | journal = J. Biol. Chem. | volume = 276 | issue = 25 | pages = 22948–53 | date = June 2001 | pmid = 11301323 | doi = 10.1074/jbc.M100087200 | doi-access = free }} and
• STAT2.{{cite journal | vauthors = Li X, Leung S, Kerr IM, Stark GR | title = Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling | journal = Mol. Cell. Biol. | volume = 17 | issue = 4 | pages = 2048–56 | date = April 1997 | pmid = 9121453 | pmc = 232052 | doi = 10.1128/mcb.17.4.2048}}{{cite journal | vauthors = Nguyen VP, Saleh AZ, Arch AE, Yan H, Piazza F, Kim J, Krolewski JJ | title = Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling | journal = J. Biol. Chem. | volume = 277 | issue = 12 | pages = 9713–21 | date = March 2002 | pmid = 11786546 | doi = 10.1074/jbc.M111161200 | doi-access = free }}

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• {{cite journal | vauthors = Caraglia M, Marra M, Pelaia G, Maselli R, Caputi M, Marsico SA, Abbruzzese A | title = Alpha-interferon and its effects on signal transduction pathways | journal = J. Cell. Physiol. | volume = 202 | issue = 2 | pages = 323–35 | year = 2005 | pmid = 15389589 | doi = 10.1002/jcp.20137 | s2cid = 4833543 | doi-access = free }}
• {{cite journal | vauthors = Raz R, Cheung K, Ling L, Levy DE | title = Three distinct loci on human chromosome 21 contribute to interferon-alpha/beta responsiveness | journal = Somat. Cell Mol. Genet. | volume = 21 | issue = 2 | pages = 139–45 | year = 1995 | pmid = 7570186 | doi = 10.1007/BF02255789 | s2cid = 972314 }}
• {{cite journal | vauthors = Lutfalla G, Holland SJ, Cinato E, Monneron D, Reboul J, Rogers NC, Smith JM, Stark GR, Gardiner K, Mogensen KE | title = Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster | journal = EMBO J. | volume = 14 | issue = 20 | pages = 5100–8 | year = 1995 | pmid = 7588638 | pmc = 394613 | doi = 10.1002/j.1460-2075.1995.tb00192.x}}
• {{cite journal | vauthors = Domanski P, Witte M, Kellum M, Rubinstein M, Hackett R, Pitha P, Colamonici OR | title = Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling | journal = J. Biol. Chem. | volume = 270 | issue = 37 | pages = 21606–11 | year = 1995 | pmid = 7665574 | doi = 10.1074/jbc.270.37.21606 | doi-access = free }}
• {{cite journal | vauthors = Novick D, Cohen B, Tal N, Rubinstein M | title = Soluble and membrane-anchored forms of the human IFN-alpha/beta receptor | journal = J. Leukoc. Biol. | volume = 57 | issue = 5 | pages = 712–8 | year = 1995 | pmid = 7759950 | doi = 10.1002/jlb.57.5.712| s2cid = 24680458 }}
• {{cite journal | vauthors = Platanias LC, Uddin S, Domanski P, Colamonici OR | title = Differences in interferon alpha and beta signaling. Interferon beta selectively induces the interaction of the alpha and betaL subunits of the type I interferon receptor | journal = J. Biol. Chem. | volume = 271 | issue = 39 | pages = 23630–3 | year = 1996 | pmid = 8798579 | doi = 10.1074/jbc.271.39.23630 | doi-access = free }}
• {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Res. | volume = 6 | issue = 9 | pages = 791–806 | year = 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 | doi-access = free }}
• {{cite journal | vauthors = Croze E, Russell-Harde D, Wagner TC, Pu H, Pfeffer LM, Perez HD | title = The human type I interferon receptor. Identification of the interferon beta-specific receptor-associated phosphoprotein | journal = J. Biol. Chem. | volume = 271 | issue = 52 | pages = 33165–8 | year = 1996 | pmid = 8969169 | doi = 10.1074/jbc.271.52.33165 | doi-access = free }}
• {{cite journal | vauthors = Li X, Leung S, Kerr IM, Stark GR | title = Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling | journal = Mol. Cell. Biol. | volume = 17 | issue = 4 | pages = 2048–56 | year = 1997 | pmid = 9121453 | pmc = 232052 | doi = 10.1128/mcb.17.4.2048}}
• {{cite journal | vauthors = Piehler J, Schreiber G | title = Biophysical analysis of the interaction of human ifnar2 expressed in E. coli with IFNalpha2 | journal = J. Mol. Biol. | volume = 289 | issue = 1 | pages = 57–67 | year = 1999 | pmid = 10339405 | doi = 10.1006/jmbi.1999.2726 }}
• {{cite journal | vauthors = Chuntharapai A, Gibbs V, Lu J, Ow A, Marsters S, Ashkenazi A, De Vos A, Jin Kim K | title = Determination of residues involved in ligand binding and signal transmission in the human IFN-alpha receptor 2 | journal = J. Immunol. | volume = 163 | issue = 2 | pages = 766–73 | year = 1999 | doi = 10.4049/jimmunol.163.2.766 | pmid = 10395669 | doi-access = free }}
• {{cite journal | vauthors = Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML | title = The DNA sequence of human chromosome 21 | journal = Nature | volume = 405 | issue = 6784 | pages = 311–9 | year = 2000 | pmid = 10830953 | doi = 10.1038/35012518 | bibcode = 2000Natur.405..311H | doi-access = free }}
• {{cite journal | vauthors = Croze E, Usacheva A, Asarnow D, Minshall RD, Perez HD, Colamonici O | title = Receptor for activated C-kinase (RACK-1), a WD motif-containing protein, specifically associates with the human type I IFN receptor | journal = J. Immunol. | volume = 165 | issue = 9 | pages = 5127–32 | year = 2000 | pmid = 11046044 | doi = 10.4049/jimmunol.165.9.5127 | doi-access = free }}
• {{cite journal | vauthors = Usacheva A, Smith R, Minshall R, Baida G, Seng S, Croze E, Colamonici O | title = The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor | journal = J. Biol. Chem. | volume = 276 | issue = 25 | pages = 22948–53 | year = 2001 | pmid = 11301323 | doi = 10.1074/jbc.M100087200 | doi-access = free }}
• {{cite journal | vauthors = Nguyen VP, Saleh AZ, Arch AE, Yan H, Piazza F, Kim J, Krolewski JJ | title = Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling | journal = J. Biol. Chem. | volume = 277 | issue = 12 | pages = 9713–21 | year = 2002 | pmid = 11786546 | doi = 10.1074/jbc.M111161200 | doi-access = free }}
• {{cite journal | vauthors = Chill JH, Nivasch R, Levy R, Albeck S, Schreiber G, Anglister J | title = The human interferon receptor: NMR-based modeling, mapping of the IFN-alpha 2 binding site, and observed ligand-induced tightening | journal = Biochemistry | volume = 41 | issue = 11 | pages = 3575–85 | year = 2002 | pmid = 11888273 | doi = 10.1021/bi011778f }}
• {{cite journal | vauthors = Velichko S, Wagner TC, Turkson J, Jove R, Croze E | title = STAT3 activation by type I interferons is dependent on specific tyrosines located in the cytoplasmic domain of interferon receptor chain 2c. Activation of multiple STATS proceeds through the redundant usage of two tyrosine residues | journal = J. Biol. Chem. | volume = 277 | issue = 38 | pages = 35635–41 | year = 2002 | pmid = 12105218 | doi = 10.1074/jbc.M204578200 | doi-access = free }}
• {{cite journal | vauthors = Usacheva A, Kotenko S, Witte MM, Colamonici OR | title = Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors | journal = J. Immunol. | volume = 169 | issue = 3 | pages = 1302–8 | year = 2002 | pmid = 12133952 | doi = 10.4049/jimmunol.169.3.1302 | doi-access = free }}
• {{cite journal | vauthors = Gauzzi MC, Canini I, Eid P, Belardelli F, Gessani S | title = Loss of type I IFN receptors and impaired IFN responsiveness during terminal maturation of monocyte-derived human dendritic cells | journal = J. Immunol. | volume = 169 | issue = 6 | pages = 3038–45 | year = 2002 | pmid = 12218119 | doi = 10.4049/jimmunol.169.6.3038 | doi-access = free }}

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{{PDB Gallery|geneid=3455}}

{{Cytokine receptors}}