IFNB1

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{{Short description|Protein-coding gene in the species Homo sapiens}}

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Interferon beta is a protein that in humans is encoded by the IFNB1 gene.{{cite web | title = Entrez Gene: IFNB1 interferon, beta 1, fibroblast| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3456}} The natural and recombinant protein forms have antiviral, antibacterial, and anticancer properties.

Interferon beta 1a (tradenames: Avonex and Rebif) and Interferon beta 1b (tradenames: Betaseron/Betaferon) are used as drugs.

References

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Further reading

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  • {{cite book |vauthors=Biron CA, Nguyen KB, Pien GC |chapter=Innate Immune Responses to LCMV Infections: Natural Killer Cells and Cytokines |title=Arenaviruses II |pages= 7–27 |year= 2002 |pmid= 11987821 |doi= 10.1007/978-3-642-56055-2_2|series=Current Topics in Microbiology and Immunology, vol. 263 |isbn=978-3-642-62724-8 }}
  • {{cite journal |vauthors=Conti L, Fantuzzi L, Del Cornò M, etal |title=Immunomodulatory effects of the HIV-1 gp120 protein on antigen presenting cells: implications for AIDS pathogenesis. |journal=Immunobiology |volume=209 |issue= 1–2 |pages= 99–115 |year= 2005 |pmid= 15481145 |doi=10.1016/j.imbio.2004.02.008 }}
  • {{cite journal |vauthors=Bekisz J, Schmeisser H, Hernandez J, etal |title=Human interferons alpha, beta and omega |journal=Growth Factors |volume=22 |issue= 4 |pages= 243–51 |year= 2005 |pmid= 15621727 |doi= 10.1080/08977190400000833 |s2cid=84918367 |url=https://zenodo.org/record/1234455 }}
  • {{cite journal | author=Copeland KF |title=Modulation of HIV-1 transcription by cytokines and chemokines |journal=Mini Reviews in Medicinal Chemistry |volume=5 |issue= 12 |pages= 1093–101 |year= 2006 |pmid= 16375755 |doi=10.2174/138955705774933383 }}
  • {{cite journal |vauthors=Silverman RH, Sengupta DN |title=Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes |journal=J. Exp. Pathol. |volume=5 |issue= 2 |pages= 69–77 |year= 1991 |pmid= 1708818 }}
  • {{cite journal |vauthors=Flores I, Mariano TM, Pestka S |title=Human interferon omega (omega) binds to the alpha/beta receptor |journal=J. Biol. Chem. |volume=266 |issue= 30 |pages= 19875–7 |year= 1991 |doi=10.1016/S0021-9258(18)54862-6 |pmid= 1834641 |doi-access=free }}
  • {{cite journal |vauthors=May LT, Sehgal PB |title=On the relationship between human interferon alpha 1 and beta 1 genes |journal=J. Interferon Res. |volume=5 |issue= 3 |pages= 521–6 |year= 1985 |pmid= 2414376 |doi= 10.1089/jir.1985.5.521}}
  • {{cite journal |vauthors=Francois DT, Katona IM, June CH, etal |title=Examination of the inhibitory and stimulatory effects of IFN-alpha, -beta, and -gamma on human B-cell proliferation induced by various B-cell mitogens |journal=Clin. Immunol. Immunopathol. |volume=48 |issue= 3 |pages= 297–306 |year= 1988 |pmid= 3135963 |doi=10.1016/0090-1229(88)90023-2 }}
  • {{cite journal |vauthors=Conradt HS, Egge H, Peter-Katalinic J, etal |title=Structure of the carbohydrate moiety of human interferon-beta secreted by a recombinant Chinese hamster ovary cell line |journal=J. Biol. Chem. |volume=262 |issue= 30 |pages= 14600–5 |year= 1987 |doi=10.1016/S0021-9258(18)47838-6 |pmid= 3667593 |doi-access=free }}
  • {{cite journal |vauthors=Blank KJ, McKernan LN, Murasko DM |title=Poly I:C or IFN-alpha/beta treatment inhibits macrophage induced T cell proliferation |journal=J. Interferon Res. |volume=5 |issue= 1 |pages= 215–21 |year= 1985 |pmid= 3872918 |doi= 10.1089/jir.1985.5.215}}
  • {{cite journal |vauthors=Derynck R, Content J, DeClercq E, etal |title=Isolation and structure of a human fibroblast interferon gene |journal=Nature |volume=285 |issue= 5766 |pages= 542–7 |year= 1980 |pmid= 6157094 |doi=10.1038/285542a0 |bibcode=1980Natur.285..542D |s2cid=4272787 }}
  • {{cite journal |vauthors=Taniguchi T, Ohno S, Fujii-Kuriyama Y, Muramatsu M |title=The nucleotide sequence of human fibroblast interferon cDNA |journal=Gene |volume=10 |issue= 1 |pages= 11–5 |year= 1980 |pmid= 6157601 |doi=10.1016/0378-1119(80)90138-9 }}
  • {{cite journal |vauthors=Houghton M, Easton MA, Stewart AG, etal |title=The complete amino acid sequence of human fibroblast interferon as deduced using synthetic oligodeoxyribonucleotide primers of reverse transcriptase |journal=Nucleic Acids Res. |volume=8 |issue= 13 |pages= 2885–94 |year= 1981 |pmid= 6159580 |doi=10.1093/nar/8.13.2885 | pmc=324132 }}
  • {{cite journal |vauthors=Goeddel DV, Shepard HM, Yelverton E, etal |title=Synthesis of human fibroblast interferon by E. coli |journal=Nucleic Acids Res. |volume=8 |issue= 18 |pages= 4057–74 |year= 1981 |pmid= 6159584 |doi=10.1093/nar/8.18.4057 | pmc=324219 }}
  • {{cite journal |vauthors=Houghton M, Stewart AG, Doel SM, etal |title=The amino-terminal sequence of human fibroblast interferon as deduced from reverse transcripts obtained using synthetic oligonucleotide primers |journal=Nucleic Acids Res. |volume=8 |issue= 9 |pages= 1913–31 |year= 1981 |pmid= 6159597 |doi=10.1093/nar/8.9.1913 | pmc=324047 }}
  • {{cite journal | author=Wetzel R |title=Assignment of the disulphide bonds of leukocyte interferon |journal=Nature |volume=289 |issue= 5798 |pages= 606–7 |year= 1981 |pmid= 6162107 |doi=10.1038/289606a0 |bibcode=1981Natur.289..606W |s2cid=4327734 }}
  • {{cite journal |vauthors=Lawn RM, Adelman J, Franke AE, etal |title=Human fibroblast interferon gene lacks introns |journal=Nucleic Acids Res. |volume=9 |issue= 5 |pages= 1045–52 |year= 1981 |pmid= 6164984 |doi=10.1093/nar/9.5.1045 | pmc=326735 }}
  • {{cite journal |vauthors=Shepard HM, Leung D, Stebbing N, Goeddel DV |title=A single amino acid change in IFN-beta1 abolishes its antiviral activity |journal=Nature |volume=294 |issue= 5841 |pages= 563–5 |year= 1982 |pmid= 6171735 |doi=10.1038/294563a0 |s2cid=4344841 }}
  • {{cite journal |vauthors=Content J, De Wit L, Pierard D, etal |title=Secretory proteins induced in human fibroblasts under conditions used for the production of interferon beta |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=79 |issue= 9 |pages= 2768–72 |year= 1982 |pmid= 6178110 |doi=10.1073/pnas.79.9.2768 | pmc=346287 |bibcode=1982PNAS...79.2768C |doi-access=free }}
  • {{cite journal |vauthors=Fiers W, Remaut E, Devos R, etal |title=The human fibroblast and human immune interferon genes and their expression in homologous and heterologous cells |journal=Philos. Trans. R. Soc. Lond. B Biol. Sci. |volume=299 |issue= 1094 |pages= 29–38 |year= 1983 |pmid= 6183692 |doi= 10.1098/rstb.1982.0103 |doi-access= }}

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