IFT74
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Intraflagellar transport protein 74 homolog (IFT74), also known as coiled-coil domain-containing protein 2 (CCDC2) and capillary morphogenesis gene 1 protein (CMG1), is a protein that in humans is encoded by the IFT74 gene.{{cite web | title = Entrez Gene: intraflagellar transport 74 homolog (Chlamydomonas)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80173}}{{cite journal |vauthors=Bell SE, Mavila A, Salazar R, Bayless KJ, Kanagala S, Maxwell SA, Davis GE | title = Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling | journal = J. Cell Sci. | volume = 114 | issue = Pt 15 | pages = 2755–73 |date=August 2001 | doi = 10.1242/jcs.114.15.2755 | pmid = 11683410 }}
BCMG1 is upregulated by umbilical vein endothelial cells during capillary morphogenesis.
References
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Further reading
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- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
- {{cite journal |vauthors=Xiao S, Sato C, Kawarai T, etal |title=Genetic studies of GRN and IFT74 in amyotrophic lateral sclerosis. |journal=Neurobiol. Aging |volume=29 |issue= 8 |pages= 1279–82 |year= 2008 |pmid= 17383054 |doi= 10.1016/j.neurobiolaging.2007.02.022 |s2cid=10392826 }}
- {{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
- {{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |pmc=1356129 |doi= 10.1101/gr.4039406 }}
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