IGFALS

The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Three transcript variants encoding two different isoforms have been found for this gene.

Defects in this gene are a cause of acid-labile subunit deficiency, which manifests itself in a delayed and slow puberty.

{{cite web |url=https://www.omim.org/entry/615961 |title=ACID-LABILE SUBUNIT DEFICIENCY; ACLSD |last=Bocchini |first=Carol A. |date=2014-08-25 |website= OMIM - An Online Catalog of Human Genes and Genetic Disorders |access-date=2024-02-21}}

IGFALS has been shown to interact with IGFBP3.{{cite journal | vauthors = Twigg SM, Baxter RC | title = Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with IGFs and the acid-labile subunit | journal = J. Biol. Chem. | volume = 273 | issue = 11 | pages = 6074–9 | date = Mar 1998 | pmid = 9497324 | doi = 10.1074/jbc.273.11.6074 | doi-access = free }}{{cite journal | vauthors = Firth SM, Ganeshprasad U, Baxter RC | title = Structural determinants of ligand and cell surface binding of insulin-like growth factor-binding protein-3 | journal = J. Biol. Chem. | volume = 273 | issue = 5 | pages = 2631–8 | date = Jan 1998 | pmid = 9446566 | doi = 10.1074/jbc.273.5.2631 | doi-access = free }}

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• {{cite journal | vauthors = Deming SL, Ren Z, Wen W, Shu XO, Cai Q, Gao YT, Zheng W | title = Genetic variation in IGF1, IGF-1R, IGFALS, and IGFBP3 in breast cancer survival among Chinese women: a report from the Shanghai Breast Cancer Study. | journal = Breast Cancer Res. Treat. | volume = 104 | issue = 3 | pages = 309–19 | year = 2007 | pmid = 17063263 | doi = 10.1007/s10549-006-9420-8 | s2cid = 31516153 }}

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