IGFBP5

{{Short description|Protein-coding gene in the species Homo sapiens}}

Insulin-like growth factor-binding protein 5 (IBF-5) is a protein that in humans is encoded by the IGFBP5 gene.{{cite journal |vauthors=Allander SV, Larsson C, Ehrenborg E, Suwanichkul A, Weber G, Morris SL, Bajalica S, Kiefer MC, Luthman H, Powell DR | title = Characterization of the chromosomal gene and promoter for human insulin-like growth factor binding protein-5 | journal = J Biol Chem | volume = 269 | issue = 14 | pages = 10891–8 |date=May 1994 | doi = 10.1016/S0021-9258(17)34142-X | pmid = 7511611 | doi-access = free }} An IGFBP5 gene was recently identified as being important for adaptation to varying water salinity in fish.{{cite journal | vauthors = Kusakabe M, Ishikawa A, Ravinet M, Yoshida K, Makino T, Toyoda A, Fujiyama A, Kitano J | title = Genetic basis for variation in salinity tolerance between stickleback ecotypes | journal = Molecular Ecology | volume = 26 | issue = 1 | pages = 304–319 | year = 2017 | pmid = 27706866 | doi = 10.1111/mec.13875 | bibcode = 2017MolEc..26..304K | s2cid = 7821799 | doi-access = free }}

References

{{cite journal |vauthors=Mohan S, Farley JR, Baylink DJ |title=Age-related changes in IGFBP-4 and IGFBP-5 levels in human serum and bone: implications for bone loss with aging. |journal=Prog. Growth Factor Res. |volume=6 |issue= 2–4 |pages= 465–73 |year= 1996 |pmid= 8817691 |doi=10.1016/0955-2235(95)00027-5 }}
{{cite journal |vauthors=Schneider MR, Wolf E, Hoeflich A, Lahm H |title=IGF-binding protein-5: flexible player in the IGF system and effector on its own |journal=J. Endocrinol. |volume=172 |issue= 3 |pages= 423–40 |year= 2002 |pmid= 11874691 |doi=10.1677/joe.0.1720423 |doi-access=free }}
{{cite journal |vauthors=Firth SM, Baxter RC |title=Cellular actions of the insulin-like growth factor binding proteins |journal=Endocr. Rev. |volume=23 |issue= 6 |pages= 824–54 |year= 2003 |pmid= 12466191 |doi=10.1210/er.2001-0033 |doi-access=free }}
{{cite journal |vauthors=Shimasaki S, Shimonaka M, Zhang HP, Ling N |title=Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human |journal=J. Biol. Chem. |volume=266 |issue= 16 |pages= 10646–53 |year= 1991 |doi=10.1016/S0021-9258(18)99272-0 |pmid= 1709938 |doi-access=free }}
{{cite journal |vauthors=Ehrenborg E, Vilhelmsdotter S, Bajalica S, etal |title=Structure and localization of the human insulin-like growth factor-binding protein 2 gene |journal=Biochem. Biophys. Res. Commun. |volume=176 |issue= 3 |pages= 1250–5 |year= 1991 |pmid= 1710112 |doi=10.1016/0006-291X(91)90420-C }}
{{cite journal |vauthors=Andress DL, Birnbaum RS |title=A novel human insulin-like growth factor binding protein secreted by osteoblast-like cells |journal=Biochem. Biophys. Res. Commun. |volume=176 |issue= 1 |pages= 213–8 |year= 1991 |pmid= 1850257 |doi=10.1016/0006-291X(91)90911-P }}
{{cite journal |vauthors=Kiefer MC, Ioh RS, Bauer DM, Zapf J |title=Molecular cloning of a new human insulin-like growth factor binding protein |journal=Biochem. Biophys. Res. Commun. |volume=176 |issue= 1 |pages= 219–25 |year= 1991 |pmid= 1850258 |doi=10.1016/0006-291X(91)90912-Q }}
{{cite journal |vauthors=Ilvesmäki V, Blum WF, Voutilainen R |title=Insulin-like growth factor binding proteins in the human adrenal gland |journal=Mol. Cell. Endocrinol. |volume=97 |issue= 1–2 |pages= 71–9 |year= 1994 |pmid= 7511544 |doi=10.1016/0303-7207(93)90212-3 |s2cid=22503525 }}
{{cite journal |vauthors=Kou K, James PL, Clemmons DR, etal |title=Identification of two clusters of mouse insulin-like growth factor binding protein genes on chromosomes 1 and 11 |journal=Genomics |volume=21 |issue= 3 |pages= 653–5 |year= 1994 |pmid= 7525452 |doi= 10.1006/geno.1994.1329 }}
{{cite journal |vauthors=Andersson B, Wentland MA, Ricafrente JY, etal |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
{{cite journal |vauthors=Yu W, Andersson B, Worley KC, etal |title=Large-Scale Concatenation cDNA Sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi= 10.1101/gr.7.4.353| pmc=139146 }}
{{cite journal |vauthors=Nam TJ, Busby W, Clemmons DR |title=Insulin-like growth factor binding protein-5 binds to plasminogen activator inhibitor-I |journal=Endocrinology |volume=138 |issue= 7 |pages= 2972–8 |year= 1997 |pmid= 9202242 |doi=10.1210/endo.138.7.5230 |doi-access=free }}
{{cite journal |vauthors=Twigg SM, Baxter RC |title=Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with IGFs and the acid-labile subunit |journal=J. Biol. Chem. |volume=273 |issue= 11 |pages= 6074–9 |year= 1998 |pmid= 9497324 |doi=10.1074/jbc.273.11.6074 |doi-access=free }}
{{cite journal |vauthors=Zheng B, Clarke JB, Busby WH, etal |title=Insulin-like growth factor-binding protein-5 is cleaved by physiological concentrations of thrombin |journal=Endocrinology |volume=139 |issue= 4 |pages= 1708–14 |year= 1998 |pmid= 9528953 |doi=10.1210/endo.139.4.5945 |doi-access=free }}
{{cite journal |vauthors=Twigg SM, Kiefer MC, Zapf J, Baxter RC |title=Insulin-like growth factor-binding protein 5 complexes with the acid-labile subunit. Role of the carboxyl-terminal domain |journal=J. Biol. Chem. |volume=273 |issue= 44 |pages= 28791–8 |year= 1998 |pmid= 9786878 |doi=10.1074/jbc.273.44.28791 |doi-access=free }}
{{cite journal |vauthors=Kalus W, Zweckstetter M, Renner C, etal |title=Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactions |journal=EMBO J. |volume=17 |issue= 22 |pages= 6558–72 |year= 1999 |pmid= 9822601 |doi= 10.1093/emboj/17.22.6558 | pmc=1171003 }}
{{cite journal |vauthors=Ständker L, Wobst P, Mark S, Forssmann WG |title=Isolation and characterization of circulating 13-kDa C-terminal fragments of human insulin-like growth factor binding protein-5 |journal=FEBS Lett. |volume=441 |issue= 2 |pages= 281–6 |year= 1999 |pmid= 9883900 |doi=10.1016/S0014-5793(98)01497-5 |s2cid=23392744 |doi-access=free }}
{{cite journal |vauthors=Kecha O, Martens H, Franchimont N, etal |title=Characterization of the insulin-like growth factor axis in the human thymus |journal=J. Neuroendocrinol. |volume=11 |issue= 6 |pages= 435–40 |year= 1999 |pmid= 10336724 |doi=10.1046/j.1365-2826.1999.00343.x |s2cid=36605514 |url=http://orbi.ulg.ac.be/handle/2268/26404 }}

IGFBP5

References

Further reading