IGHV@
{{Short description|Protein}}
{{Infobox_gene}}
Ig heavy chain V-III region VH26 is a protein that in humans is encoded by the IGHV@ gene.{{cite journal |vauthors=Walter MA, Dosch HM, Cox DW | title = A deletion map of the human immunoglobulin heavy chain variable region | journal = J Exp Med | volume = 174 | issue = 2 | pages = 335–49 |date=Aug 1991 | pmid = 1649888 | pmc = 2118905 | doi =10.1084/jem.174.2.335 }}{{cite journal |author1=Schroeder HW Jr |author2=Walter MA |author3=Hofker MH |author4=Ebens A |author5=Willems van Dijk K |author6=Liao LC |author7=Cox DW |author8=Milner EC |author9=Perlmutter RM | title = Physical linkage of a human immunoglobulin heavy chain variable region gene segment to diversity and joining region elements | journal = Proc Natl Acad Sci U S A | volume = 85 | issue = 21 | pages = 8196–200 |date=Dec 1988 | pmid = 3141924 | pmc = 282394 | doi =10.1073/pnas.85.21.8196 |bibcode=1988PNAS...85.8196S |doi-access=free }}{{cite web | title = Entrez Gene: IGHV@ immunoglobulin heavy variable group| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3509| accessdate = }}
IGHV is the immunoglobulin heavy chain variable region genes; in B-cell neoplasms like chronic lymphocytic leukemia, mutations of IGHV are associated with better responses to some treatments and with prolonged survival.{{cite journal
|vauthors=Forconi F, Sozzi E, Cencini E, etal |title=Hairy cell leukemias with unmutated IGHV genes define the minor subset refractory to single agent cladribine and with more aggressive behavior
|journal=Blood
|volume=114
|issue=21
|pages=4696–4702
|date=November 2009
|pmid=19667403
|doi=10.1182/blood-2009-03-212449
|url=http://bloodjournal.hematologylibrary.org/cgi/content/full/114/21/4696
|doi-access=free
}}
See also
References
{{reflist}}
Further reading
{{refbegin | 2}}
- {{cite journal |vauthors=Matsuda F, Shin EK, Hirabayashi Y, etal |title=Organization of variable region segments of the human immunoglobulin heavy chain: duplication of the D5 cluster within the locus and interchromosomal translocation of variable region segments. |journal=EMBO J. |volume=9 |issue= 8 |pages= 2501–6 |year= 1990 |pmid= 2114977 |doi= 10.1002/j.1460-2075.1990.tb07429.x| pmc=552279 }}
- {{cite journal |vauthors=Cherif D, Berger R |title=New localizations of VH sequences by in situ hybridization with biotinylated probes. |journal=Genes Chromosomes Cancer |volume=2 |issue= 2 |pages= 103–8 |year= 1991 |pmid= 2126193 |doi=10.1002/gcc.2870020205 |s2cid=22489747 }}
- {{cite journal |vauthors=Toyonaga B, Yoshikai Y, Vadasz V, etal |title=Organization and sequences of the diversity, joining, and constant region genes of the human T-cell receptor beta chain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=82 |issue= 24 |pages= 8624–8 |year= 1986 |pmid= 3866244 |doi=10.1073/pnas.82.24.8624 | pmc=390970 |doi-access=free }}
- {{cite journal |vauthors=Matthyssens G, Rabbitts TH |title=Structure and multiplicity of genes for the human immunoglobulin heavy chain variable region. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=77 |issue= 11 |pages= 6561–5 |year= 1981 |pmid= 6450418 |doi=10.1073/pnas.77.11.6561 | pmc=350325 |doi-access=free }}
- {{cite journal |vauthors=Mariette X, Tsapis A, Brouet JC |title=Nucleotidic sequence analysis of the variable domains of four human monoclonal IgM with an antibody activity to myelin-associated glycoprotein. |journal=Eur. J. Immunol. |volume=23 |issue= 4 |pages= 846–51 |year= 1993 |pmid= 7681398 |doi=10.1002/eji.1830230412 |s2cid=38756102 }}
- {{cite journal |vauthors=Boursier L, Su W, Spencer J |title=Imprint of somatic hypermutation differs in human immunoglobulin heavy and lambda chain variable gene segments. |journal=Mol. Immunol. |volume=39 |issue= 16 |pages= 1025–34 |year= 2003 |pmid= 12749909 |doi=10.1016/S0161-5890(03)00033-6 }}
- {{cite journal |vauthors=Nakamura N, Nakamura S, Yamaguchi M, etal |title=CD5+ diffuse large B-cell lymphoma consists of germline cases and hypermutated cases in the immunoglobulin heavy chain gene variable region. |journal=Int. J. Hematol. |volume=81 |issue= 1 |pages= 58–61 |year= 2005 |pmid= 15717690 |doi=10.1532/IJH97.04119 |s2cid=22639228 }}
- {{cite journal |vauthors=Suárez E, Magadán S, Sanjuán I, etal |title=Rearrangement of only one human IGHV gene is sufficient to generate a wide repertoire of antigen specific antibody responses in transgenic mice. |journal=Mol. Immunol. |volume=43 |issue= 11 |pages= 1827–35 |year= 2006 |pmid= 16343622 |doi= 10.1016/j.molimm.2005.10.015 }}
- {{cite journal |vauthors=Balogh Z, Reiniger L, Deák L, etal |title=IgVH gene mutation status and genomic imbalances in chronic lymphocytic leukaemia with increased prolymphocytes (CLL/PL). |journal=Hematological Oncology |volume=25 |issue= 2 |pages= 90–5 |year= 2007 |pmid= 17410523 |doi= 10.1002/hon.812 |s2cid=19587621 }}
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