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IGSF8

{{Short description|Protein-coding gene in the species Homo sapiens}}

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Immunoglobulin superfamily member 8 is a protein that in humans is encoded by the IGSF8 gene.{{cite journal | vauthors = Stipp CS, Kolesnikova TV, Hemler ME | title = EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily | journal = J Biol Chem | volume = 276 | issue = 44 | pages = 40545–40554 | date = Oct 2001 | pmid = 11504738 | doi = 10.1074/jbc.M107338200 | doi-access = free }}{{cite journal | vauthors = Clark KL, Zeng Z, Langford AL, Bowen SM, Todd SC | title = PGRL is a major CD81-associated protein on lymphocytes and distinguishes a new family of cell surface proteins | journal = J Immunol | volume = 167 | issue = 9 | pages = 5115–5121 | date = Oct 2001 | pmid = 11673522 | doi = 10.4049/jimmunol.167.9.5115 | doi-access = free }}{{cite web | title = Entrez Gene: IGSF8 immunoglobulin superfamily, member 8 | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=93185 }} IGSF8 has also been designated as CD316 (cluster of differentiation 316). IGSF8 is an innate immune checkpoint that inhibits the cytotoxic activity of natural killer (NK) cells.{{Cite journal | date = May 2024 | title = IGSF8 is an innate immune checkpoint and cancer immunotherapy target | url = https://linkinghub.elsevier.com/retrieve/pii/S0092867424003556 | journal = Cell | volume = 187 | issue = 11 | pages = 2703–2716.e23 | doi = 10.1016/j.cell.2024.03.039 | pmid = 38657602 | issn = 0092-8674 | vauthors = Li Y, Wu X, Sheng C, Liu H, Liu H, Tang Y, Liu C, Ding Q, Xie B, Xiao X, Zheng R, Yu Q, Guo Z, Ma J, Wang J }} IGSF8 acts by binding to the Killer Ig-like Receptor KIR3DL2 (or, in mice, the analogous Klra9 receptor). IGSF8 is frequently overexpressed relative to normal tissues in many cancers, included melanoma, urothelial carcinoma, and breast cancer, and has been proposed as a potential therapeutic target in gliomas.{{Cite journal | date = September 2024 | title = IGSF8 is a potential target for the treatment of gliomas | url = https://linkinghub.elsevier.com/retrieve/pii/S1015958424003804 | journal = Asian Journal of Surgery | language = en | volume = 47 | issue = 9 | pages = 3883–3891 | doi = 10.1016/j.asjsur.2024.02.118 | doi-access = free | vauthors = Ren J, Huang P, Wang F }} In normal tissues, IGSF8 is highly expressed in the brain, where it may contribute to the immune privilege of the central nervous system.

Cancer biomarker

In gliomas, IGSF8 is strongly correlated with tumor grade and is a potential prognostic marker. IGSF8 is enriched on ovarian cancer-derived extracellular vesicles and is a potential biomarker for the early detection of high grade serous ovarian cancer.{{Cite journal | date = 2023-10-26 | title = Lineage specific extracellular vesicle-associated protein biomarkers for the early detection of high grade serous ovarian cancer | journal = Scientific Reports | language = en | volume = 13 | issue = 1 | page = 18341 | doi = 10.1038/s41598-023-44050-5 | issn = 2045-2322 | pmc = 10603107 | pmid = 37884576 | bibcode = 2023NatSR..1318341T | vauthors = Trinidad CV, Pathak HB, Cheng S, Tzeng S, Madan R, Sardiu ME, Bantis LE, Deighan C, Jewell A, Rayamajhi S, Zeng Y, Godwin AK }}

References

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Further reading

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  • {{cite journal | vauthors = Strausberg RL, Feingold EA, Grouse LH, etal | title = Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 26 | pages = 16899–16903 | year = 2003 | pmid = 12477932 | doi = 10.1073/pnas.242603899 | pmc = 139241 | bibcode = 2002PNAS...9916899M | doi-access = free }}
  • {{cite journal | vauthors = Charrin S, Le Naour F, Labas V, etal | title = EWI-2 is a new component of the tetraspanin web in hepatocytes and lymphoid cells. | journal = Biochem. J. | volume = 373 | issue = Pt 2 | pages = 409–421 | year = 2003 | pmid = 12708969 | doi = 10.1042/BJ20030343 | pmc = 1223506 }}
  • {{cite journal | vauthors = Zhang XA, Lane WS, Charrin S, etal | title = EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells. | journal = Cancer Res. | volume = 63 | issue = 10 | pages = 2665–2674 | year = 2003 | pmid = 12750295 }}
  • {{cite journal | vauthors = Bonkobara M, Das A, Takao J, etal | title = Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes. | journal = Br. J. Dermatol. | volume = 148 | issue = 4 | pages = 654–664 | year = 2003 | pmid = 12752121 | doi = 10.1046/j.1365-2133.2003.05244.x | s2cid = 21635573 }}
  • {{cite journal | vauthors = Stipp CS, Kolesnikova TV, Hemler ME | title = EWI-2 regulates alpha3beta1 integrin-dependent cell functions on laminin-5. | journal = J. Cell Biol. | volume = 163 | issue = 5 | pages = 1167–1177 | year = 2004 | pmid = 14662754 | doi = 10.1083/jcb.200309113 | pmc = 2173626 }}
  • {{cite journal | vauthors = Ota T, Suzuki Y, Nishikawa T, etal | title = Complete sequencing and characterization of 21,243 full-length human cDNAs. | journal = Nat. Genet. | volume = 36 | issue = 1 | pages = 40–45 | year = 2004 | pmid = 14702039 | doi = 10.1038/ng1285 | doi-access = free }}
  • {{cite journal | vauthors = Kolesnikova TV, Stipp CS, Rao RM, etal | title = EWI-2 modulates lymphocyte integrin alpha4beta1 functions. | journal = Blood | volume = 103 | issue = 8 | pages = 3013–3019 | year = 2004 | pmid = 15070678 | doi = 10.1182/blood-2003-07-2201 | doi-access = free }}
  • {{cite journal | vauthors = Gerhard DS, Wagner L, Feingold EA, etal | title = The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | journal = Genome Res. | volume = 14 | issue = 10B | pages = 2121–2127 | year = 2004 | pmid = 15489334 | doi = 10.1101/gr.2596504 | pmc = 528928 }}
  • {{cite journal | vauthors = Yang XH, Kovalenko OV, Kolesnikova TV, etal | title = Contrasting effects of EWI proteins, integrins, and protein palmitoylation on cell surface CD9 organization. | journal = J. Biol. Chem. | volume = 281 | issue = 18 | pages = 12976–12985 | year = 2006 | pmid = 16537545 | doi = 10.1074/jbc.M510617200 | doi-access = free }}
  • {{cite journal | vauthors = Sala-Valdés M, Ursa A, Charrin S, etal | title = EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins. | journal = J. Biol. Chem. | volume = 281 | issue = 28 | pages = 19665–19675 | year = 2006 | pmid = 16690612 | doi = 10.1074/jbc.M602116200 | doi-access = free }}
  • {{cite journal | vauthors = Kettner S, Kalthoff F, Graf P, etal | title = EWI-2/CD316 is an inducible receptor of HSPA8 on human dendritic cells. | journal = Mol. Cell. Biol. | volume = 27 | issue = 21 | pages = 7718–7726 | year = 2007 | pmid = 17785435 | doi = 10.1128/MCB.00180-07 | pmc = 2169036 }}

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External links

  • {{MeshName|IGSF8+protein,+human}}

{{Clusters of differentiation}}

Category:Clusters of differentiation

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