IKZF4
{{Infobox_gene}}
Zinc finger protein Eos is a protein that in humans is encoded by the IKZF4 gene.{{cite journal |vauthors=Perdomo J, Holmes M, Chong B, Crossley M | title = Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities | journal = J Biol Chem | volume = 275 | issue = 49 | pages = 38347–54 |date=Jan 2001 | pmid = 10978333 | doi = 10.1074/jbc.M005457200 | doi-access = free }}{{cite web | title = Entrez Gene: IKZF4 IKAROS family zinc finger 4 (Eos)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64375}}
Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM]
Interactions
IKZF4 has been shown to interact with CTBP1{{cite journal |last=Perdomo |first=José |author2=Crossley Merlin |date=Dec 2002 |title=The Ikaros family protein Eos associates with C-terminal-binding protein corepressors |journal=Eur. J. Biochem. |volume=269 |issue=23 |pages=5885–92 |location = Germany| issn = 0014-2956| pmid = 12444977 |doi=10.1046/j.1432-1033.2002.03313.x |doi-access=free }} and IKZF1.{{cite journal |last=Honma |first=Y |author2=Kiyosawa H |author3=Mori T |author4=Oguri A |author5=Nikaido T |author6=Kanazawa K |author7=Tojo M |author8=Takeda J |author9=Tanno Y |author10=Yokoya S |author11=Kawabata I |author12=Ikeda H |author13=Wanaka A |date=Mar 1999 |title=Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system |journal=FEBS Lett. |volume=447 |issue=1 |pages=76–80 |location = NETHERLANDS| issn = 0014-5793| pmid = 10218586 |doi=10.1016/S0014-5793(99)00265-3 |s2cid=28898354 |doi-access=free }}
References
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Further reading
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- {{cite journal | author=Kimura K |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |name-list-style=vanc| author2=Wakamatsu A | author3=Suzuki Y | display-authors=3 | last4=Ota | first4=T | last5=Nishikawa | first5=T | last6=Yamashita | first6=R | last7=Yamamoto | first7=J | last8=Sekine | first8=M | last9=Tsuritani | first9=K }}
- {{cite journal | author=Bao J |title=Activity-dependent transcription regulation of PSD-95 by neuregulin-1 and Eos |journal=Nat. Neurosci. |volume=7 |issue= 11 |pages= 1250–8 |year= 2005 |pmid= 15494726 |doi= 10.1038/nn1342 |name-list-style=vanc| author2=Lin H | author3=Ouyang Y | display-authors=3 | last4=Lei | first4=Debin | last5=Osman | first5=Abdullah | last6=Kim | first6=Tae-Wan | last7=Mei | first7=Lin | last8=Dai | first8=Penggao | last9=Ohlemiller | first9=Kevin K |s2cid=1964177 }}
- {{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-style=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki | doi-access=free }}
- {{cite journal |vauthors=Perdomo J, Crossley M |title=The Ikaros family protein Eos associates with C-terminal-binding protein corepressors |journal=Eur. J. Biochem. |volume=269 |issue= 23 |pages= 5885–92 |year= 2003 |pmid= 12444977 |doi=10.1046/j.1432-1033.2002.03313.x |doi-access=free }}
- {{cite journal |vauthors=Koipally J, Georgopoulos K |title=A molecular dissection of the repression circuitry of Ikaros |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 27697–705 |year= 2002 |pmid= 12015313 |doi= 10.1074/jbc.M201694200 |doi-access= free }}
- {{cite journal | author=Nagase T |title=Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=8 |issue= 2 |pages= 85–95 |year= 2001 |pmid= 11347906 |doi=10.1093/dnares/8.2.85 |name-list-style=vanc| author2=Nakayama M | author3=Nakajima D | display-authors=3 | last4=Kikuno | first4=R | last5=Ohara | first5=O |doi-access=free}}
- {{cite journal | author=Honma Y |title=Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system |journal=FEBS Lett. |volume=447 |issue= 1 |pages= 76–80 |year= 1999 |pmid= 10218586 |doi=10.1016/S0014-5793(99)00265-3 |name-list-style=vanc| author2=Kiyosawa H | author3=Mori T | display-authors=3 | last4=Oguri | first4=A | last5=Nikaido | first5=T | last6=Kanazawa | first6=K | last7=Tojo | first7=M | last8=Takeda | first8=J | last9=Tanno | first9=Y |s2cid=28898354 | doi-access=free }}
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