IL13RA2

IL-13Rα2 is closely related to IL-13Rα1, a subunit of the interleukin-13 receptor complex. This protein binds IL13 with high affinity, but lacks any significant cytoplasmic domain, and does not appear to function as a signal mediator. It is, however, able to regulate the effects of both IL-13 and IL-4, despite the fact it is unable to bind directly to the latter. It is also reported to play a role in the internalization of IL13.

== Clinical Significance ==

IL-13Rα2 has been found to be over-expressed in a variety of cancers, including pancreatic, ovarian, melanomas, and malignant gliomas. {{cite journal | vauthors = Fujisawa T, Joshi B, Nakajima A, Puri RK | title = A novel role of interleukin-13 receptor alpha2 in pancreatic cancer invasion and metastasis | journal = Cancer Research | volume = 69 | issue = 22 | pages = 8678–85 | date = November 2009 | pmid = 19887609 | doi = 10.1158/0008-5472.CAN-09-2100 | url = http://cancerres.aacrjournals.org/content/69/22/8678 | doi-access = free }}{{cite journal | vauthors = Kioi M, Kawakami M, Shimamura T, Husain SR, Puri RK | title = Interleukin-13 receptor alpha2 chain: a potential biomarker and molecular target for ovarian cancer therapy | journal = Cancer | volume = 107 | issue = 6 | pages = 1407–18 | date = September 2006 | pmid = 16902988 | doi = 10.1002/cncr.22134 | s2cid = 70773746 | doi-access = free }}{{cite journal | vauthors = Okamoto H, Yoshimatsu Y, Tomizawa T, Kunita A, Takayama R, Morikawa T, Komura D, Takahashi K, Oshima T, Sato M, Komai M, Podyma-Inoue KA, Uchida H, Hamada H, Fujiu K, Ishikawa S, Fukayama M, Fukuhara T, Watabe T | title = Interleukin-13 receptor α2 is a novel marker and potential therapeutic target for human melanoma | journal = Scientific Reports | volume = 9 | issue = 1 | pages = 1281 | date = February 2019 | pmid = 30718742 | pmc = 6362032 | doi = 10.1038/s41598-019-39018-3 | bibcode = 2019NatSR...9.1281O }}{{cite journal | vauthors = Joshi BH, Plautz GE, Puri RK | title = Interleukin-13 receptor alpha chain: a novel tumor-associated transmembrane protein in primary explants of human malignant gliomas | journal = Cancer Research | volume = 60 | issue = 5 | pages = 1168–72 | date = March 2000 | pmid = 10728667 | url = http://cancerres.aacrjournals.org/content/60/5/1168 }}

• Interleukin-13 receptor

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• {{cite journal | vauthors = Andrews AL, Nasir T, Bucchieri F, Holloway JW, Holgate ST, Davies DE | title = IL-13 receptor alpha 2: a regulator of IL-13 and IL-4 signal transduction in primary human fibroblasts | journal = The Journal of Allergy and Clinical Immunology | volume = 118 | issue = 4 | pages = 858–65 | date = October 2006 | pmid = 17030238 | doi = 10.1016/j.jaci.2006.06.041 | doi-access = free }}
• {{cite journal | vauthors = Caput D, Laurent P, Kaghad M, Lelias JM, Lefort S, Vita N, Ferrara P | title = Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain | journal = The Journal of Biological Chemistry | volume = 271 | issue = 28 | pages = 16921–6 | date = July 1996 | pmid = 8663118 | doi = 10.1074/jbc.271.28.16921 | doi-access = free }}
• {{cite journal | vauthors = Zhang JG, Hilton DJ, Willson TA, McFarlane C, Roberts BA, Moritz RL, Simpson RJ, Alexander WS, Metcalf D, Nicola NA | title = Identification, purification, and characterization of a soluble interleukin (IL)-13-binding protein. Evidence that it is distinct from the cloned Il-13 receptor and Il-4 receptor alpha-chains | journal = The Journal of Biological Chemistry | volume = 272 | issue = 14 | pages = 9474–80 | date = April 1997 | pmid = 9083087 | doi = 10.1074/jbc.272.14.9474 | doi-access = free}}
• {{cite journal | vauthors = Gauchat JF, Schlagenhauf E, Feng NP, Moser R, Yamage M, Jeannin P, Alouani S, Elson G, Notarangelo LD, Wells T, Eugster HP, Bonnefoy JY | title = A novel 4-kb interleukin-13 receptor alpha mRNA expressed in human B, T, and endothelial cells encoding an alternate type-II interleukin-4/interleukin-13 receptor | journal = European Journal of Immunology | volume = 27 | issue = 4 | pages = 971–8 | date = April 1997 | pmid = 9130652 | doi = 10.1002/eji.1830270425 | s2cid = 23762963 }}
• {{cite journal | vauthors = Guo J, Apiou F, Mellerin MP, Lebeau B, Jacques Y, Minvielle S | title = Chromosome mapping and expression of the human interleukin-13 receptor | journal = Genomics | volume = 42 | issue = 1 | pages = 141–5 | date = May 1997 | pmid = 9177784 | doi = 10.1006/geno.1997.4628 }}
• {{cite journal | vauthors = Donaldson DD, Whitters MJ, Fitz LJ, Neben TY, Finnerty H, Henderson SL, O'Hara RM, Beier DR, Turner KJ, Wood CR, Collins M | title = The murine IL-13 receptor alpha 2: molecular cloning, characterization, and comparison with murine IL-13 receptor alpha 1 | journal = Journal of Immunology | volume = 161 | issue = 5 | pages = 2317–24 | date = September 1998 | doi = 10.4049/jimmunol.161.5.2317 | pmid = 9725226 | s2cid = 255357984 }}
• {{cite journal | vauthors = Osawa M, Miyoshi S, Copeland NG, Gilbert DJ, Jenkins NA, Hiroyama T, Motohashi T, Nakamura Y, Iwama A, Nakauchi H | title = Characterization of the mouse interleukin-13 receptor alpha1 gene | journal = Immunogenetics | volume = 51 | issue = 11 | pages = 974–81 | date = September 2000 | pmid = 11003391 | doi = 10.1007/s002510000225 | s2cid = 9030454 }}
• {{cite journal | vauthors = Kawakami K, Takeshita F, Puri RK | title = Identification of distinct roles for a dileucine and a tyrosine internalization motif in the interleukin (IL)-13 binding component IL-13 receptor alpha 2 chain | journal = The Journal of Biological Chemistry | volume = 276 | issue = 27 | pages = 25114–20 | date = July 2001 | pmid = 11352909 | doi = 10.1074/jbc.M100936200 | doi-access = free }}
• {{cite journal | vauthors = Daines MO, Hershey GK | title = A novel mechanism by which interferon-gamma can regulate interleukin (IL)-13 responses. Evidence for intracellular stores of IL-13 receptor alpha -2 and their rapid mobilization by interferon-gamma | journal = The Journal of Biological Chemistry | volume = 277 | issue = 12 | pages = 10387–93 | date = March 2002 | pmid = 11786536 | doi = 10.1074/jbc.M108109200 | doi-access = free }}
• {{cite journal | vauthors = Okano F, Storkus WJ, Chambers WH, Pollack IF, Okada H | title = Identification of a novel HLA-A*0201-restricted, cytotoxic T lymphocyte epitope in a human glioma-associated antigen, interleukin 13 receptor alpha2 chain | journal = Clinical Cancer Research | volume = 8 | issue = 9 | pages = 2851–5 | date = September 2002 | pmid = 12231526 }}
• {{cite journal | vauthors = Cancino-Díaz JC, Reyes-Maldonado E, Bañuelos-Pánuco CA, Jiménez-Zamudio L, García-Latorre E, León-Dorantes G, Blancas-González F, Paredes-Cabrera G, Cancino-Díaz ME | title = Interleukin-13 receptor in psoriatic keratinocytes: overexpression of the mRNA and underexpression of the protein | journal = The Journal of Investigative Dermatology | volume = 119 | issue = 5 | pages = 1114–20 | date = November 2002 | pmid = 12445201 | doi = 10.1046/j.1523-1747.2002.19509.x | doi-access = free }}
• {{cite journal | vauthors = David M, Bertoglio J, Pierre J | title = TNF-alpha potentiates IL-4/IL-13-induced IL-13Ralpha2 expression | journal = Annals of the New York Academy of Sciences | volume = 973 | pages = 207–9 | date = November 2002 | issue = 1 | pmid = 12485861 | doi = 10.1111/j.1749-6632.2002.tb04633.x | bibcode = 2002NYASA.973..207D | s2cid = 86154739 }}
• {{cite journal | vauthors = Wu AH, Low WC | title = Molecular cloning and identification of the human interleukin 13 alpha 2 receptor (IL-13Ra2) promoter | journal = Neuro-Oncology | volume = 5 | issue = 3 | pages = 179–87 | date = July 2003 | pmid = 12816724 | pmc = 1920687 | doi = 10.1215/s1152851702000510 }}
• {{cite journal | vauthors = Arima K, Sato K, Tanaka G, Kanaji S, Terada T, Honjo E, Kuroki R, Matsuo Y, Izuhara K | title = Characterization of the interaction between interleukin-13 and interleukin-13 receptors | journal = The Journal of Biological Chemistry | volume = 280 | issue = 26 | pages = 24915–22 | date = July 2005 | pmid = 15870068 | doi = 10.1074/jbc.M502571200 | doi-access = free }}
• {{cite journal | vauthors = Fichtner-Feigl S, Strober W, Kawakami K, Puri RK, Kitani A | title = IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis | journal = Nature Medicine | volume = 12 | issue = 1 | pages = 99–106 | date = January 2006 | pmid = 16327802 | doi = 10.1038/nm1332 | s2cid = 38397076 }}
• {{cite journal | vauthors = Daines MO, Tabata Y, Walker BA, Chen W, Warrier MR, Basu S, Hershey GK | title = Level of expression of IL-13R alpha 2 impacts receptor distribution and IL-13 signaling | journal = Journal of Immunology | volume = 176 | issue = 12 | pages = 7495–501 | date = June 2006 | pmid = 16751396 | doi = 10.4049/jimmunol.176.12.7495 | doi-access = free }}
• {{cite journal | vauthors = Kioi M, Kawakami M, Shimamura T, Husain SR, Puri RK | title = Interleukin-13 receptor alpha2 chain: a potential biomarker and molecular target for ovarian cancer therapy | journal = Cancer | volume = 107 | issue = 6 | pages = 1407–18 | date = September 2006 | pmid = 16902988 | doi = 10.1002/cncr.22134 | s2cid = 70773746 | doi-access = free }}
• {{cite journal | vauthors = Granel B, Allanore Y, Chevillard C, Arnaud V, Marquet S, Weiller PJ, Durand JM, Harlé JR, Grange C, Frances Y, Berbis P, Gaudart J, de Micco P, Kahan A, Dessein A | title = IL13RA2 gene polymorphisms are associated with systemic sclerosis | journal = The Journal of Rheumatology | volume = 33 | issue = 10 | pages = 2015–9 | date = October 2006 | pmid = 16981293 }}

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• {{MeshName|IL13RA2+protein,+human}}
• {{PDBe-KB2|Q14627|Interleukin-13 receptor subunit alpha-2}}

{{NLM content}}

{{Clusters of differentiation}}

{{Interleukin receptor modulators}}

Category:Clusters of differentiation

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