IL18R1
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
The interleukin-18 receptor 1 (IL-18R1) is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is its human gene.{{cite web | title = Entrez Gene: IL18R1 interleukin 18 receptor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8809}} IL18R1 is also known as CDw218a (cluster of differentiation w218a).
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q.
See also
References
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Further reading
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- {{cite journal |vauthors=Sergi B, Penttila I |title=Interleukin 18 receptor |journal=J. Biol. Regul. Homeost. Agents |volume=18 |issue= 1 |pages= 55–61 |year= 2005 |pmid= 15323361 }}
- {{cite journal | author=Parnet P |title=IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP |journal=J. Biol. Chem. |volume=271 |issue= 8 |pages= 3967–70 |year= 1996 |pmid= 8626725 |doi=10.1074/jbc.271.8.3967 |name-list-style=vanc| author2=Garka KE | author3=Bonnert TP | display-authors=3 | last4=Dower | first4=SK | last5=Sims | first5=JE |doi-access=free}}
- {{cite journal | author=Lovenberg TW |title=Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2) |journal=J. Neuroimmunol. |volume=70 |issue= 2 |pages= 113–22 |year= 1996 |pmid= 8898719 |doi=10.1016/S0165-5728(96)00047-1 |name-list-style=vanc| author2=Crowe PD | author3=Liu C | display-authors=3 | last4=Chalmers | first4=Derek T. | last5=Liu | first5=Xin-Jun | last6=Liaw | first6=Chen | last7=Clevenger | first7=William | last8=Oltersdorf | first8=Tilman | last9=De Souza | first9=Errol B. |s2cid=53171191 }}
- {{cite journal | author=Torigoe K |title=Purification and characterization of the human interleukin-18 receptor |journal=J. Biol. Chem. |volume=272 |issue= 41 |pages= 25737–42 |year= 1997 |pmid= 9325300 |doi=10.1074/jbc.272.41.25737 |name-list-style=vanc| author2=Ushio S | author3=Okura T | display-authors=3 | last4=Kobayashi | first4=S | last5=Taniai | first5=M | last6=Kunikata | first6=T | last7=Murakami | first7=T | last8=Sanou | first8=O | last9=Kojima | first9=H | doi-access=free }}
- {{cite journal |vauthors=Dale M, Nicklin MJ |title=Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q |journal=Genomics |volume=57 |issue= 1 |pages= 177–9 |year= 1999 |pmid= 10191101 |doi= 10.1006/geno.1999.5767 }}
- {{cite journal | author=Hoshino K |title=Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor |journal=J. Immunol. |volume=162 |issue= 9 |pages= 5041–4 |year= 1999 |pmid= 10227969 |name-list-style=vanc| author2=Tsutsui H | author3=Kawai T | display-authors=3 | last4=Takeda | first4=K | last5=Nakanishi | first5=K | last6=Takeda | first6=Y | last7=Akira | first7=S |doi=10.4049/jimmunol.162.9.5041 |s2cid=37333739 | doi-access=free}}
- {{cite journal |vauthors=Sareneva T, Julkunen I, Matikainen S |title=IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells |journal=J. Immunol. |volume=165 |issue= 4 |pages= 1933–8 |year= 2000 |pmid= 10925275 |doi= 10.4049/jimmunol.165.4.1933|doi-access=free }}
- {{cite journal | author=Kumar S |title=Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production |journal=Cytokine |volume=18 |issue= 2 |pages= 61–71 |year= 2003 |pmid= 12096920 |doi=10.1006/cyto.2002.0873 |name-list-style=vanc| author2=Hanning CR | author3=Brigham-Burke MR | display-authors=3 | last4=Rieman | first4=David J. | last5=Lehr | first5=Ruth | last6=Khandekar | first6=Sanjay | last7=Kirkpatrick | first7=Robert B. | last8=Scott | first8=Gilbert F. | last9=Lee | first9=John C. }}
- {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-style=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal | author=Gutzmer R |title=Human dendritic cells express the IL-18R and are chemoattracted to IL-18 |journal=J. Immunol. |volume=171 |issue= 12 |pages= 6363–71 |year= 2004 |pmid= 14662834 |doi= 10.4049/jimmunol.171.12.6363|name-list-style=vanc| author2=Langer K | author3=Mommert S | display-authors=3 | last4=Wittmann | first4=M | last5=Kapp | first5=A | last6=Werfel | first6=T | doi-access=free}}
- {{cite journal | author=Azam T |title=Identification of a critical Ig-like domain in IL-18 receptor alpha and characterization of a functional IL-18 receptor complex |journal=J. Immunol. |volume=171 |issue= 12 |pages= 6574–80 |year= 2004 |pmid= 14662859 |doi= 10.4049/jimmunol.171.12.6574|name-list-style=vanc| author2=Novick D | author3=Bufler P | display-authors=3 | last4=Yoon | first4=DY | last5=Rubinstein | first5=M | last6=Dinarello | first6=CA | last7=Kim | first7=SH | doi-access=free }}
- {{cite journal | author=Towne JE |title=Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs |journal=J. Biol. Chem. |volume=279 |issue= 14 |pages= 13677–88 |year= 2004 |pmid= 14734551 |doi= 10.1074/jbc.M400117200 |name-list-style=vanc| author2=Garka KE | author3=Renshaw BR | display-authors=3 | last4=Virca | first4=GD | last5=Sims | first5=JE |doi-access=free }}
- {{cite journal |vauthors=Cardoso SP, Keen L, Bidwell J |title=Identification of two novel single nucleotide polymorphisms in the promoter of the human interleukin-18 receptor alpha |journal=Eur. J. Immunogenet. |volume=31 |issue= 1 |pages= 27–9 |year= 2004 |pmid= 15009178 |doi=10.1111/j.1365-2370.2004.00441.x }}
- {{cite journal | author=Reddy SA |title=The IL-1 receptor accessory protein is essential for PI 3-kinase recruitment and activation |journal=Biochem. Biophys. Res. Commun. |volume=316 |issue= 4 |pages= 1022–8 |year= 2004 |pmid= 15044087 |doi= 10.1016/j.bbrc.2004.02.155 |name-list-style=vanc| author2=Lin YF | author3=Huang HJ | display-authors=3 | last4=Samanta | first4=Ajoy K | last5=Liao | first5=Warren S.-L }}
- {{cite journal | author=Yoon- DY |title=Up-regulation of reactive oxygen species (ROS) and resistance to Fas-mediated apoptosis in the C33A cervical cancer cell line transfected with IL-18 receptor |journal=Clin. Chem. Lab. Med. |volume=42 |issue= 5 |pages= 499–506 |year= 2005 |pmid= 15202785 |doi=10.1515/CCLM.2004.085 |name-list-style=vanc| author2=Cho YS | author3=Park JW | display-authors=3 | last4=Kim | first4=Soo-Hyun | last5=Kim | first5=Jong-Wan |s2cid=38410716 }}
- {{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-style=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}
- {{cite journal |vauthors=Fukushima K, Ikehara Y, Yamashita K |title=Functional role played by the glycosylphosphatidylinositol anchor glycan of CD48 in interleukin-18-induced interferon-gamma production |journal=J. Biol. Chem. |volume=280 |issue= 18 |pages= 18056–62 |year= 2005 |pmid= 15760905 |doi= 10.1074/jbc.M413297200 |doi-access= free }}
- {{cite journal | author=Hillier LW |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4 |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 |name-list-style=vanc| author2=Graves TA | author3=Fulton RS | display-authors=3 | last4=Fulton | first4=Lucinda A. | last5=Pepin | first5=Kymberlie H. | last6=Minx | first6=Patrick | last7=Wagner-Mcpherson | first7=Caryn | last8=Layman | first8=Dan | last9=Wylie | first9=Kristine |bibcode=2005Natur.434..724H | doi-access=free }}
- {{cite journal | author=Sahar S |title=Angiotensin II enhances interleukin-18 mediated inflammatory gene expression in vascular smooth muscle cells: a novel cross-talk in the pathogenesis of atherosclerosis |journal=Circ. Res. |volume=96 |issue= 10 |pages= 1064–71 |year= 2005 |pmid= 15860756 |doi= 10.1161/01.RES.0000168210.10358.f4 |name-list-style=vanc| author2=Dwarakanath RS | author3=Reddy MA | display-authors=3 | last4=Lanting | first4=L | last5=Todorov | first5=I | last6=Natarajan | first6=R | doi-access=free}}
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External links
- {{MeshName|IL18R1+protein,+human}}
{{NLM content}}
{{Clusters of differentiation}}
{{Immune receptors}}
{{Cytokine receptors}}
{{Interleukin receptor modulators}}
Category:Clusters of differentiation
Category:Immunoglobulin superfamily cytokine receptors
{{membrane-protein-stub}}