IL1F10
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{{Short description|Human protein and coding gene}}
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Interleukin-1 family member 10 is a protein that in humans is encoded by the IL1F10 gene.{{cite journal |vauthors=Bensen JT, Dawson PA, Mychaleckyj JC, Bowden DW | title = Identification of a novel human cytokine gene in the interleukin gene cluster on chromosome 2q12-14 | journal = J Interferon Cytokine Res | volume = 21 | issue = 11 | pages = 899–904 |date=Dec 2001 | pmid = 11747621 | doi = 10.1089/107999001753289505 }}{{cite journal |vauthors=Taylor SL, Renshaw BR, Garka KE, Smith DE, Sims JE | title = Genomic organization of the interleukin-1 locus | journal = Genomics | volume = 79 | issue = 5 | pages = 726–33 |date=May 2002 | pmid = 11991723 | doi = 10.1006/geno.2002.6752 }}{{cite journal |vauthors=Nicklin MJ, Barton JL, Nguyen M, FitzGerald MG, Duff GW, Kornman K | title = A sequence-based map of the nine genes of the human interleukin-1 cluster | journal = Genomics | volume = 79 | issue = 5 | pages = 718–25 |date=May 2002 | pmid = 11991722 | doi = 10.1006/geno.2002.6751 }}{{cite web | title = Entrez Gene: IL1F10 interleukin 1 family, member 10 (theta)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84639}}
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. This cytokine is thought to participate in a network of interleukin 1 family members to regulate adapted and innate immune responses. Two alternatively spliced transcript variants encoding the same protein have been reported.
References
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Further reading
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- {{cite journal |vauthors=Nicklin MJ, Weith A, Duff GW |title=A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes. |journal=Genomics |volume=19 |issue= 2 |pages= 382–4 |year= 1994 |pmid= 8188271 |doi= 10.1006/geno.1994.1076 }}
- {{cite journal |vauthors=Nothwang HG, Strahm B, Denich D, etal |title=Molecular cloning of the interleukin-1 gene cluster: construction of an integrated YAC/PAC contig and a partial transcriptional map in the region of chromosome 2q13. |journal=Genomics |volume=41 |issue= 3 |pages= 370–8 |year= 1997 |pmid= 9169134 |doi= 10.1006/geno.1997.4654 }}
- {{cite journal |vauthors=Mulero JJ, Pace AM, Nelken ST, etal |title=IL1HY1: A novel interleukin-1 receptor antagonist gene. |journal=Biochem. Biophys. Res. Commun. |volume=263 |issue= 3 |pages= 702–6 |year= 1999 |pmid= 10512743 |doi= 10.1006/bbrc.1999.1440 }}
- {{cite journal |vauthors=Smith DE, Renshaw BR, Ketchem RR, etal |title=Four new members expand the interleukin-1 superfamily. |journal=J. Biol. Chem. |volume=275 |issue= 2 |pages= 1169–75 |year= 2000 |pmid= 10625660 |doi=10.1074/jbc.275.2.1169 |doi-access=free }}
- {{cite journal |vauthors=Kumar S, McDonnell PC, Lehr R, etal |title=Identification and initial characterization of four novel members of the interleukin-1 family. |journal=J. Biol. Chem. |volume=275 |issue= 14 |pages= 10308–14 |year= 2000 |pmid= 10744718 |doi=10.1074/jbc.275.14.10308 |doi-access=free }}
- {{cite journal |vauthors=Busfield SJ, Comrack CA, Yu G, etal |title=Identification and gene organization of three novel members of the IL-1 family on human chromosome 2. |journal=Genomics |volume=66 |issue= 2 |pages= 213–6 |year= 2000 |pmid= 10860666 |doi= 10.1006/geno.2000.6184 }}
- {{cite journal |vauthors=Barton JL, Herbst R, Bosisio D, etal |title=A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities. |journal=Eur. J. Immunol. |volume=30 |issue= 11 |pages= 3299–308 |year= 2001 |pmid= 11093146 |doi=10.1002/1521-4141(200011)30:11<3299::AID-IMMU3299>3.0.CO;2-S |doi-access=free }}
- {{cite journal |vauthors=Pan G, Risser P, Mao W, etal |title=IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp. |journal=Cytokine |volume=13 |issue= 1 |pages= 1–7 |year= 2001 |pmid= 11145836 |doi= 10.1006/cyto.2000.0799 }}
- {{cite journal |vauthors=Lin H, Ho AS, Haley-Vicente D, etal |title=Cloning and characterization of IL-1HY2, a novel interleukin-1 family member. |journal=J. Biol. Chem. |volume=276 |issue= 23 |pages= 20597–602 |year= 2001 |pmid= 11278614 |doi= 10.1074/jbc.M010095200 |doi-access= free }}
- {{cite journal |vauthors=Debets R, Timans JC, Homey B, etal |title=Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2. |journal=Journal of Immunology |volume=167 |issue= 3 |pages= 1440–6 |year= 2001 |pmid= 11466363 |doi= 10.4049/jimmunol.167.3.1440|s2cid=85986577 |doi-access= }}
- {{cite journal |vauthors=Sims JE, Nicklin MJ, Bazan JF, etal |title=A new nomenclature for IL-1-family genes. |journal=Trends Immunol. |volume=22 |issue= 10 |pages= 536–7 |year= 2001 |pmid= 11574262 |doi=10.1016/S1471-4906(01)02040-3 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Hillier LW, Graves TA, Fulton RS, etal |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 |bibcode=2005Natur.434..724H |doi-access= free }}
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{{Cytokines}}
{{Interleukin receptor modulators}}
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