IL1RL2
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Interleukin-1 receptor-like 2 is a protein that in humans is encoded by the IL1RL2 gene.{{cite journal |vauthors=Lovenberg TW, Crowe PD, Liu C, Chalmers DT, Liu XJ, Liaw C, Clevenger W, Oltersdorf T, De Souza EB, Maki RA | title = Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2) | journal = J Neuroimmunol | volume = 70 | issue = 2 | pages = 113–22 |date=Dec 1996 | pmid = 8898719 | doi =10.1016/S0165-5728(96)00047-1 | s2cid = 53171191 }}{{cite journal |vauthors=Dale M, Nicklin MJ | title = Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q | journal = Genomics | volume = 57 | issue = 1 | pages = 177–9 |date=Jun 1999 | pmid = 10191101 | doi = 10.1006/geno.1999.5767 }}{{cite journal |vauthors=Debets R, Timans JC, Homey B, Zurawski S, Sana TR, Lo S, Wagner J, Edwards G, Clifford T, Menon S, Bazan JF, Kastelein RA | title = Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2 | journal = Journal of Immunology | volume = 167 | issue = 3 | pages = 1440–6 |date=Jul 2001 | pmid = 11466363 | doi = 10.4049/jimmunol.167.3.1440| doi-access = free }}{{cite web | title = Entrez Gene: IL1RL2 interleukin 1 receptor-like 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8808}}
The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.
References
{{reflist}}
Further reading
{{refbegin | 2}}
- {{cite journal |vauthors=McMahan CJ, Slack JL, Mosley B, etal |title=A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types. |journal=EMBO J. |volume=10 |issue= 10 |pages= 2821–32 |year= 1991 |pmid= 1833184 |doi= 10.1002/j.1460-2075.1991.tb07831.x| pmc=452992 }}
- {{cite journal |vauthors=Colotta F, Re F, Muzio M, etal |title=Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4. |journal=Science |volume=261 |issue= 5120 |pages= 472–5 |year= 1993 |pmid= 8332913 |doi=10.1126/science.8332913 |bibcode=1993Sci...261..472C }}
- {{cite journal |vauthors=Torigoe K, Ushio S, Okura T, etal |title=Purification and characterization of the human interleukin-18 receptor. |journal=J. Biol. Chem. |volume=272 |issue= 41 |pages= 25737–42 |year= 1997 |pmid= 9325300 |doi=10.1074/jbc.272.41.25737 |doi-access=free }}
- {{cite journal |vauthors=Born TL, Smith DE, Garka KE, etal |title=Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling. |journal=J. Biol. Chem. |volume=275 |issue= 39 |pages= 29946–54 |year= 2000 |pmid= 10882729 |doi= 10.1074/jbc.M004077200 |doi-access= free }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Ozkara C, Uzan M, Tanriverdi T, etal |title=Lack of association between IL-1beta/alpha gene polymorphisms and temporal lobe epilepsy with hippocampal sclerosis. |journal=Seizure: The Journal of the British Epilepsy Association |volume=15 |issue= 5 |pages= 288–91 |year= 2006 |pmid= 16546408 |doi= 10.1016/j.seizure.2006.02.016 |doi-access= free }}
{{refend}}
{{Cytokine receptors}}
{{Interleukin receptor modulators}}
{{gene-2-stub}}