IL2RB

The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit (also called CD25) and is not involved in signal transduction. The intermediate affinity form consists of a gamma/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein.

This protein also forms one of the three subunits of the IL-15 receptor.

Activation of the receptor increases proliferation of CD8+ effector T cells.{{cite journal

|vauthors=Boyman O, Sprent J |title=The role of interleukin-2 during homeostasis and activation of the immune system

|journal=Nat Rev Immunol |volume=12 |issue=3 |pages=180–190

|date=February 17, 2012 |doi= 10.1038/nri3156 |pmid=22343569

|s2cid=22680847

}}

IL2RB has been shown to interact with:

• CISH,{{cite journal | vauthors = Aman MJ, Migone TS, Sasaki A, Ascherman DP, ((Zhu Mh)), Soldaini E, Imada K, Miyajima A, Yoshimura A, Leonard WJ | title = CIS associates with the interleukin-2 receptor beta chain and inhibits interleukin-2-dependent signaling | journal = J. Biol. Chem. | volume = 274 | issue = 42 | pages = 30266–72 | date = October 1999 | pmid = 10514520 | doi = 10.1074/jbc.274.42.30266| doi-access = free }}
• HGS,{{cite journal | vauthors = Yamashita Y, Kojima K, Tsukahara T, Agawa H, Yamada K, Amano Y, Kurotori N, Tanaka N, Sugamura K, Takeshita T | title = Ubiquitin-independent binding of Hrs mediates endosomal sorting of the interleukin-2 receptor beta-chain | journal = J. Cell Sci. | volume = 121 | issue = Pt 10 | pages = 1727–38 | date = May 2008 | pmid = 18445679 | doi = 10.1242/jcs.024455 | doi-access = free }}
• Janus kinase 1,{{cite journal | vauthors = Miyazaki T, Kawahara A, Fujii H, Nakagawa Y, Minami Y, Liu ZJ, Oishi I, Silvennoinen O, Witthuhn BA, Ihle JN | title = Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits | journal = Science | volume = 266 | issue = 5187 | pages = 1045–7 | date = November 1994 | pmid = 7973659 | doi = 10.1126/science.7973659| bibcode = 1994Sci...266.1045M }}{{cite journal | vauthors = Russell SM, Johnston JA, Noguchi M, Kawamura M, Bacon CM, Friedmann M, Berg M, McVicar DW, Witthuhn BA, Silvennoinen O | title = Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID | journal = Science | volume = 266 | issue = 5187 | pages = 1042–5 | date = November 1994 | pmid = 7973658 | doi = 10.1126/science.7973658| bibcode = 1994Sci...266.1042R | url = https://zenodo.org/record/1231239 }}{{cite journal | vauthors = Usacheva A, Kotenko S, Witte MM, Colamonici OR | title = Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors | journal = J. Immunol. | volume = 169 | issue = 3 | pages = 1302–8 | date = August 2002 | pmid = 12133952 | doi = 10.4049/jimmunol.169.3.1302| doi-access = free }}{{cite journal | vauthors = Zhu MH, Berry JA, Russell SM, Leonard WJ | title = Delineation of the regions of interleukin-2 (IL-2) receptor beta chain important for association of Jak1 and Jak3. Jak1-independent functional recruitment of Jak3 to Il-2Rbeta | journal = J. Biol. Chem. | volume = 273 | issue = 17 | pages = 10719–25 | date = April 1998 | pmid = 9553136 | doi = 10.1074/jbc.273.17.10719| doi-access = free }}{{cite journal | vauthors = Migone TS, Rodig S, Cacalano NA, Berg M, Schreiber RD, Leonard WJ | title = Functional cooperation of the interleukin-2 receptor beta chain and Jak1 in phosphatidylinositol 3-kinase recruitment and phosphorylation | journal = Mol. Cell. Biol. | volume = 18 | issue = 11 | pages = 6416–22 | date = November 1998 | pmid = 9774657 | pmc = 109227 | doi = 10.1128/mcb.18.11.6416}} and
• SHC1.{{cite journal | vauthors = Delespine-Carmagnat M, Bouvier G, Bertoglio J | title = Association of STAT1, STAT3 and STAT5 proteins with the IL-2 receptor involves different subdomains of the IL-2 receptor beta chain | journal = Eur. J. Immunol. | volume = 30 | issue = 1 | pages = 59–68 | date = January 2000 | pmid = 10602027 | doi = 10.1002/1521-4141(200001)30:1<59::AID-IMMU59>3.0.CO;2-1 | s2cid = 40742391 }}{{cite journal | vauthors = Ravichandran KS, Burakoff SJ | title = The adapter protein Shc interacts with the interleukin-2 (IL-2) receptor upon IL-2 stimulation | journal = J. Biol. Chem. | volume = 269 | issue = 3 | pages = 1599–602 | date = January 1994 | doi = 10.1016/S0021-9258(17)42066-7 | pmid = 8294403 | doi-access = free }}

• IL-2 receptor
• IL-15 receptor

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{{NLM content}}

{{PDB Gallery|geneid=3560}}

{{Cytokine receptors}}

{{Clusters of differentiation}}

{{Interleukin receptor modulators}}