INPP4B
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Inositol polyphosphate-4-phosphatase, type II, 105kDa is a protein that in humans is encoded by the INPP4B gene.{{cite web | title = Entrez Gene: Inositol polyphosphate-4-phosphatase, type II, 105kDa | url = https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=8821 | access-date = 2012-07-24 }}
INPP4B encodes the inositol polyphosphate 4-phosphatase type II, a dual specificity phosphatase. INPP4B is involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate and phosphate groups from phosphotyrosines.{{cite journal | vauthors = Lopez SM, Hodgson MC, Packianathan C, Bingol-Ozakpinar O, Uras F, Rosen BP, Agoulnik IU | title = Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities | journal = Biochemical and Biophysical Research Communications | volume = 440 | issue = 2 | pages = 277–82 | date = October 2013 | pmid = 24070612 | pmc = 4578723 | doi = 10.1016/j.bbrc.2013.09.077 }} There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme.
References
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Further reading
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- {{cite journal | vauthors = Lopez SM, Hodgson MC, Packianathan C, Bingol-Ozakpinar O, Uras F, Rosen BP, Agoulnik IU | title = Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities | journal = Biochemical and Biophysical Research Communications | volume = 440 | issue = 2 | pages = 277–82 | date = October 2013 | pmid = 24070612 | pmc = 4578723 | doi = 10.1016/j.bbrc.2013.09.077 }}
- {{cite journal | vauthors = Gewinner C, Wang ZC, Richardson A, Teruya-Feldstein J, Etemadmoghadam D, Bowtell D, Barretina J, Lin WM, Rameh L, Salmena L, Pandolfi PP, Cantley LC | title = Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling | journal = Cancer Cell | volume = 16 | issue = 2 | pages = 115–25 | date = August 2009 | pmid = 19647222 | pmc = 2957372 | doi = 10.1016/j.ccr.2009.06.006 }}
- {{cite journal | vauthors = Hodgson MC, Shao LJ, Frolov A, Li R, Peterson LE, Ayala G, Ittmann MM, Weigel NL, Agoulnik IU | title = Decreased expression and androgen regulation of the tumor suppressor gene INPP4B in prostate cancer | journal = Cancer Research | volume = 71 | issue = 2 | pages = 572–82 | date = January 2011 | pmid = 21224358 | pmc = 3077543 | doi = 10.1158/0008-5472.CAN-10-2314 }}
- {{cite journal | vauthors = Norris FA, Atkins RC, Majerus PW | title = The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family | journal = The Journal of Biological Chemistry | volume = 272 | issue = 38 | pages = 23859–64 | date = September 1997 | pmid = 9295334 | doi = 10.1074/jbc.272.38.23859 | doi-access = free }}
- {{cite journal | vauthors = Munday AD, Norris FA, Caldwell KK, Brown S, Majerus PW, Mitchell CA | title = The inositol polyphosphate 4-phosphatase forms a complex with phosphatidylinositol 3-kinase in human platelet cytosol | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 7 | pages = 3640–5 | date = March 1999 | pmid = 10097090 | pmc = 22347 | doi = 10.1073/pnas.96.7.3640 | bibcode = 1999PNAS...96.3640M | doi-access = free }}
- {{cite journal | vauthors = Amato R, Pinelli M, Monticelli A, Miele G, Cocozza S | title = Schizophrenia and vitamin D related genes could have been subject to latitude-driven adaptation | journal = BMC Evolutionary Biology | volume = 10 | pages = 351 | date = November 2010 | issue = 1 | pmid = 21070662 | pmc = 2996405 | doi = 10.1186/1471-2148-10-351 | bibcode = 2010BMCEE..10..351A | doi-access = free }}
- {{cite journal | vauthors = Norris FA, Auethavekiat V, Majerus PW | title = The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase | journal = The Journal of Biological Chemistry | volume = 270 | issue = 27 | pages = 16128–33 | date = July 1995 | pmid = 7608176 | doi = 10.1074/jbc.270.27.16128 | doi-access = free }}
- {{cite journal | vauthors = Rampersaud E, Damcott CM, Fu M, Shen H, McArdle P, Shi X, Shelton J, Yin J, Chang YP, Ott SH, Zhang L, Zhao Y, Mitchell BD, O'Connell J, Shuldiner AR | title = Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the Old Order Amish: evidence for replication from diabetes-related quantitative traits and from independent populations | journal = Diabetes | volume = 56 | issue = 12 | pages = 3053–62 | date = December 2007 | pmid = 17846126 | doi = 10.2337/db07-0457 | doi-access = free }}
- {{cite journal | vauthors = Fedele CG, Ooms LM, Ho M, Vieusseux J, O'Toole SA, Millar EK, Lopez-Knowles E, Sriratana A, Gurung R, Baglietto L, Giles GG, Bailey CG, Rasko JE, Shields BJ, Price JT, Majerus PW, Sutherland RL, Tiganis T, McLean CA, Mitchell CA | title = Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 107 | issue = 51 | pages = 22231–6 | date = December 2010 | pmid = 21127264 | pmc = 3009830 | doi = 10.1073/pnas.1015245107 | bibcode = 2010PNAS..10722231F | doi-access = free }}
- {{cite journal | vauthors = Zhang X, Majerus PW | title = Phosphatidylinositol signalling reactions | journal = Seminars in Cell & Developmental Biology | volume = 9 | issue = 2 | pages = 153–60 | date = April 1998 | pmid = 9599410 | doi = 10.1006/scdb.1997.0220 }}
- {{cite journal | vauthors = Agoulnik IU, Hodgson MC, Bowden WA, Ittmann MM | title = INPP4B: the new kid on the PI3K block | journal = Oncotarget | volume = 2 | issue = 4 | pages = 321–8 | date = April 2011 | pmid = 21487159 | pmc = 3248162 | doi = 10.18632/oncotarget.260 }}
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