INPP5A
{{Short description|Protein-coding gene in the species Homo sapiens}}
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Type I inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the INPP5A gene.{{cite journal |vauthors=De Smedt F, Verjans B, Mailleux P, Erneux C | title = Cloning and expression of human brain type I inositol 1,4,5-trisphosphate 5-phosphatase. High levels of mRNA in cerebellar Purkinje cells | journal = FEBS Lett | volume = 347 | issue = 1 | pages = 69–72 |date=Jul 1994 | pmid = 8013665 | doi =10.1016/0014-5793(94)00509-5 | s2cid = 4936881 | doi-access = }}{{cite web | title = Entrez Gene: INPP5A inositol polyphosphate-5-phosphatase, 40kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3632}}
The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins (1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation.
References
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Further reading
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- {{cite journal |vauthors=Laxminarayan KM, Chan BK, Tetaz T, etal |title=Characterization of a cDNA encoding the 43-kDa membrane-associated inositol-polyphosphate 5-phosphatase. |journal=J. Biol. Chem. |volume=269 |issue= 25 |pages= 17305–10 |year= 1994 |doi=10.1016/S0021-9258(17)32555-3 |pmid= 8006039 |doi-access=free }}
- {{cite journal |vauthors=Mitchell CA, Speed CJ, Nicholl J, Sutherland GR | authorlink4=Grant Robert Sutherland |title=Chromosomal mapping of the gene (INPP5A) encoding the 43-kDa membrane-associated inositol polyphosphate 5-phosphatase to 10q26.3 by fluorescence in situ hybridization. |journal=Genomics |volume=31 |issue= 1 |pages= 139–40 |year= 1996 |pmid= 8808294 |doi= 10.1006/geno.1996.0023 }}
- {{cite journal |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 |doi-access=free }}
- {{cite journal |vauthors=Auethavekiat V, Abrams CS, Majerus PW |title=Phosphorylation of platelet pleckstrin activates inositol polyphosphate 5-phosphatase I. |journal=J. Biol. Chem. |volume=272 |issue= 3 |pages= 1786–90 |year= 1997 |pmid= 8999861 |doi=10.1074/jbc.272.3.1786 |doi-access=free }}
- {{cite journal |vauthors=Campbell JK, Gurung R, Romero S, etal |title=Activation of the 43 kDa inositol polyphosphate 5-phosphatase by 14-3-3zeta. |journal=Biochemistry |volume=36 |issue= 49 |pages= 15363–70 |year= 1998 |pmid= 9398266 |doi= 10.1021/bi9708085 }}
- {{cite journal |vauthors=Lee SH, Davison JA, Vidal SM, Belouchi A |title=Cloning, expression and chromosomal location of NKX6B TO 10Q26, a region frequently deleted in brain tumors. |journal=Mamm. Genome |volume=12 |issue= 2 |pages= 157–62 |year= 2001 |pmid= 11210186 |doi=10.1007/s003350010247 |s2cid=22368753 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Hartmann TB, Thiel D, Dummer R, etal |title=SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma. |journal=Br. J. Dermatol. |volume=150 |issue= 2 |pages= 252–8 |year= 2004 |pmid= 14996095 |doi=10.1111/j.1365-2133.2004.05651.x |s2cid=42495130 }}
- {{cite journal |vauthors=Deloukas P, Earthrowl ME, Grafham DV, etal |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 |bibcode=2004Natur.429..375D |doi-access= free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
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