IQSEC1

The ARF-GEP₁₀₀ protein is involved in signal transduction. It is a guanine nucleotide exchange factor that promotes binding of GTP to ADP ribosylation factor protein ARF6 and to a lesser extent ARF1 and ARF5. This activates the ADP-ribosylation activity of the target protein and cause it to modify its substrates. ARF-GEP₁₀₀, through activation of ARF6, is therefore involved in the control of processes such as endocytosis of plasma membrane proteins, E-cadherin recycling and actin cytoskeleton remodeling.{{cite journal |vauthors=Hiroi T, Someya A, Thompson W, Moss J, Vaughan M | title = GEP100/BRAG2: Activator of ADP-ribosylation factor 6 for regulation of cell adhesion and actin cytoskeleton via E-cadherin and α-catenin | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 103 | issue = 28 | pages = 10672–7 | year = 2006 | pmid = 16807291 | doi = 10.1073/pnas.0604091103| pmc = 1502290 | bibcode = 2006PNAS..10310672H | doi-access = free }} ARF-GEP₁₀₀ appears particularly important in regulating cell adhesion, with reductions in the level of this protein causing enhanced spreading and attachment of cells.{{cite journal |vauthors=Dunphy JL, Moravec R, Ly K, Lasell TK, Melancon P, Casanova JE | title = The Arf6 GEF GEP100/BRAG2 regulates cell adhesion by controlling endocytosis of beta1 integrins | journal = Curr. Biol. | volume = 16 | issue = 3 | pages = 315–20 | year = 2006 | pmid = 16461286 | doi = 10.1016/j.cub.2005.12.032 | pmc = 3600433 | bibcode = 2006CBio...16..315D }}

It is highly expressed in the prefrontal cortex, and throughout the rest of the brain, and is believed to have a role in learning and memory, having been detected as phosphorylated in a phospho screen of the PSD.{{cite journal |vauthors=Trinidad JC, Specht CG, Thalhammer A, Schoepfer R, Burlingame AL | title = Comprehensive identification of phosphorylation sites in postsynaptic density preparations | journal = Mol. Cell. Proteomics | volume = 5 | issue = 5 | pages = 914–22 |date=May 2006 | pmid = 16452087 | doi = 10.1074/mcp.T500041-MCP200 | doi-access = free }}

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• {{MeshName|IQSEC1+protein,+human}}

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