IRF2BP2
{{Short description|Protein-coding gene in the species Homo sapiens}}{{Infobox_gene}}
Interferon regulatory factor 2 binding protein 2 is a protein that in humans is encoded by the IRF2BP2 gene.
{{cite web
| title = Entrez Gene: Interferon regulatory factor 2 binding protein 2
| url = https://www.ncbi.nlm.nih.gov/gene/359948
| access-date = 2017-01-06
}}
Function
This gene encodes an interferon regulatory factor-2 (IRF2) binding protein that interacts with the C-terminal transcriptional repression domain of IRF2. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
References
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Further reading
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- {{cite journal |vauthors=Childs KS, Goodbourn S |title=Identification of novel co-repressor molecules for Interferon Regulatory Factor-2 |journal=Nucleic Acids Res. |volume=31 |issue=12 |pages=3016–26 |year=2003 |pmid=12799427 |pmc=162335 |doi= 10.1093/nar/gkg431}}
- {{cite journal |vauthors=Tinnikov AA, Yeung KT, Das S, Samuels HH |title=Identification of a novel pathway that selectively modulates apoptosis of breast cancer cells |journal=Cancer Res. |volume=69 |issue=4 |pages=1375–82 |year=2009 |pmid=19190336 |pmc=4264605 |doi=10.1158/0008-5472.CAN-08-2896 }}
- {{cite journal |vauthors=Teng AC, Kuraitis D, Deeke SA, Ahmadi A, Dugan SG, Cheng BL, Crowson MG, Burgon PG, Suuronen EJ, Chen HH, Stewart AF |title=IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression |journal=FASEB J. |volume=24 |issue=12 |pages=4825–34 |year=2010 |pmid=20702774 |doi=10.1096/fj.10-167049 |doi-access=free |s2cid=35708173 }}
- {{cite journal |vauthors=Teng AC, Kuraitis D, Deeke SA, Ahmadi A, Dugan SG, Cheng BL, Crowson MG, Burgon PG, Suuronen EJ, Chen HH, Stewart AF |title=IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression |journal=FASEB J. |volume=24 |issue=12 |pages=4825–34 |year=2010 |pmid=20702774 |doi=10.1096/fj.10-167049 |doi-access=free |s2cid=35708173 }}
- {{cite journal |vauthors=Carneiro FR, Ramalho-Oliveira R, Mognol GP, Viola JP |title=Interferon regulatory factor 2 binding protein 2 is a new NFAT1 partner and represses its transcriptional activity |journal=Mol. Cell. Biol. |volume=31 |issue=14 |pages=2889–901 |year=2011 |pmid=21576369 |pmc=3133407 |doi=10.1128/MCB.00974-10 }}
- {{cite journal |vauthors=Teng AC, Al-Montashiri NA, Cheng BL, Lou P, Ozmizrak P, Chen HH, Stewart AF |title=Identification of a phosphorylation-dependent nuclear localization motif in interferon regulatory factor 2 binding protein 2 |journal=PLOS ONE |volume=6 |issue=8 |pages=e24100 |year=2011 |pmid=21887377 |pmc=3162591 |doi=10.1371/journal.pone.0024100 |bibcode=2011PLoSO...624100T |doi-access=free }}
- {{cite journal |vauthors=Nyquist KB, Panagopoulos I, Thorsen J, Haugom L, Gorunova L, Bjerkehagen B, Fosså A, Guriby M, Nome T, Lothe RA, Skotheim RI, Heim S, Micci F |title=Whole-transcriptome sequencing identifies novel IRF2BP2-CDX1 fusion gene brought about by translocation t(1;5)(q42;q32) in mesenchymal chondrosarcoma |journal=PLOS ONE |volume=7 |issue=11 |pages=e49705 |year=2012 |pmid=23185413 |pmc=3504151 |doi=10.1371/journal.pone.0049705 |bibcode=2012PLoSO...749705N |doi-access=free }}
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