IRX2
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Iroquois-class homeodomain protein IRX-2, also known as Iroquois homeobox protein 2, is a protein that in humans is encoded by the IRX2 gene.{{cite web | title = Entrez Gene: iroquois homeobox 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=153572 }}{{cite journal |vauthors=Ogura K, Matsumoto K, Kuroiwa A, Isobe T, Otoguro T, Jurecic V, Baldini A, Matsuda Y, Ogura T | title = Cloning and chromosome mapping of human and chicken Iroquois (IRX) genes | journal = Cytogenet. Cell Genet. | volume = 92 | issue = 3–4 | pages = 320–5 | year = 2001 | pmid = 11435706 | doi = 10.1159/000056921| s2cid = 46509502 }}
Function
IRX2 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.
Cancer
IRX2 gene has been observed progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy. {{cite journal | vauthors = Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F | title = Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes. | journal = J Cell Physiol | volume = 230| issue = 4 | pages = 802–812 | date = April 2015 | pmid = 25205602 | doi = 10.1002/jcp.24808| hdl = 11392/2066612 | s2cid = 24986454 | hdl-access = free }} For this reason, IRX2 is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression. {{cite journal | vauthors = Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F | title = Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes. | journal = J Cell Physiol | volume = 230| issue = 4 | pages = 802–812 | date = April 2015 | pmid = 25205602 | doi = 10.1002/jcp.24808| hdl = 11392/2066612 | s2cid = 24986454 | hdl-access = free }}
References
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Further reading
{{refbegin | 2}}
- {{cite journal |vauthors=Lam CY, Tam PO, Fan DS, etal |title=A genome-wide scan maps a novel high myopia locus to 5p15 |journal=Invest. Ophthalmol. Vis. Sci. |volume=49 |issue= 9 |pages= 3768–78 |year= 2008 |pmid= 18421076 |doi= 10.1167/iovs.07-1126 |doi-access= free }}
- {{cite journal |vauthors=Cirulli ET, Kasperavičiūtė D, Attix DK, etal |title=Common genetic variation and performance on standardized cognitive tests |journal=European Journal of Human Genetics |volume= 18|issue= 7|pages= 815–20 |year= 2010 |pmid= 20125193 |pmc=2987367 |doi= 10.1038/ejhg.2010.2 }}
- {{cite journal |vauthors=Adamowicz M, Radlwimmer B, Rieker RJ, etal |title=Frequent amplifications and abundant expression of TRIO, NKD2, and IRX2 in soft tissue sarcomas |journal=Genes Chromosomes Cancer |volume=45 |issue= 9 |pages= 829–38 |year= 2006 |pmid= 16752383 |doi= 10.1002/gcc.20343 |s2cid=24491021 }}
- {{cite journal |vauthors=Matsumoto K, Nishihara S, Kamimura M, etal |title=The prepattern transcription factor Irx2, a target of the FGF8/MAP kinase cascade, is involved in cerebellum formation |journal=Nat. Neurosci. |volume=7 |issue= 6 |pages= 605–12 |year= 2004 |pmid= 15133517 |doi= 10.1038/nn1249 |s2cid=23807922 }}
- {{cite journal |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1996 |pmid= 8889548 |doi=10.1101/gr.6.9.791 |doi-access=free }}
- {{cite journal |vauthors=Lewis MT, Ross S, Strickland PA, etal |title=Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast |journal=Cell Tissue Res. |volume=296 |issue= 3 |pages= 549–54 |year= 1999 |pmid= 10370142 |doi=10.1007/s004410051316 |s2cid=37046813 |url=https://escholarship.org/uc/item/6q61x39v }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |pmc=139241 |doi= 10.1073/pnas.242603899 |bibcode=2002PNAS...9916899M |doi-access=free }}
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{{Transcription factors|g3}}
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