IRX4

{{Short description|Protein-coding gene in the species Homo sapiens}}

Iroquois-class homeodomain protein IRX-4, also known as Iroquois homeobox protein 4, is a protein that in humans is encoded by the IRX4 gene.{{cite web | title = Entrez Gene: iroquois homeobox 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50805 }}{{cite journal |vauthors=Bruneau BG, Bao ZZ, Tanaka M, Schott JJ, Izumo S, Cepko CL, Seidman JG, Seidman CE | title = Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand | journal = Dev. Biol. | volume = 217 | issue = 2 | pages = 266–77 |date=January 2000 | pmid = 10625552 | doi = 10.1006/dbio.1999.9548 | doi-access = free }}

Function

IRX4 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.

References

{{cite journal |vauthors=Lewis MT, Ross S, Strickland PA, etal |title=Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast. |journal=Cell Tissue Res. |volume=296 |issue= 3 |pages= 549–54 |year= 1999 |pmid= 10370142 |doi= 10.1007/s004410051316|s2cid=37046813 |url=https://escholarship.org/uc/item/6q61x39v |url-access=subscription }}
{{cite journal |vauthors=Wang GF, Nikovits W, Bao ZZ, Stockdale FE |title=Irx4 forms an inhibitory complex with the vitamin D and retinoic X receptors to regulate cardiac chamber-specific slow MyHC3 expression. |journal=J. Biol. Chem. |volume=276 |issue= 31 |pages= 28835–41 |year= 2001 |pmid= 11382777 |doi= 10.1074/jbc.M103716200 |doi-access= free }}
{{cite journal |vauthors=Bayrak F, Kömürcü-Bayrak E, Mutlu B, etal |title=Genetic analysis of the Irx4 gene in hypertrophic cardiomyopathy. |journal=Turk Kardiyol Dern Ars |volume=36 |issue= 2 |pages= 90–5 |year= 2008 |pmid= 18497553 }}
{{cite journal |vauthors=Cirulli ET, Kasperavičiūtė D, Attix DK, etal |title=Common genetic variation and performance on standardized cognitive tests. |journal=European Journal of Human Genetics |volume= 18|issue= 7|pages= 815–820 |year= 2010 |pmid= 20125193 |doi= 10.1038/ejhg.2010.2 |pmc=2987367}}
{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241|bibcode=2002PNAS...9916899M |doi-access=free }}

IRX4

Function

References

Further reading