ITPK1

{{Short description|Protein-coding gene in the species Homo sapiens}}

Inositol-tetrakisphosphate 1-kinase is an enzyme that in humans is encoded by the ITPK1 gene.{{cite journal |vauthors=Wilson MP, Majerus PW | title = Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme | journal = J Biol Chem | volume = 271 | issue = 20 | pages = 11904–10 |date=Aug 1996 | pmid = 8662638 | doi =10.1074/jbc.271.20.11904 | doi-access = free }}{{cite journal |vauthors=Yang X, Shears SB | title = Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P(4) 1-kinase/Ins(1,3,4)P(3) 5/6-kinase | journal = Biochem J | volume = 351 | issue = 3| pages = 551–5 |date=Jan 2001 | pmid = 11042108 | pmc = 1221393 | doi = 10.1042/0264-6021:3510551}}{{cite web | title = Entrez Gene: ITPK1 inositol 1,3,4-triphosphate 5/6 kinase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3705}}

It is involved in inositol signalling pathways which regulate the conductance of calcium-activated chloride channels, and therefore could be relevant in the study of cystic fibrosis.{{cite journal |vauthors=Saiardi A, Cockcroft S | title = Human ITPK1: a reversible inositol phosphate kinase/phosphatase that links receptor-dependent phospholipase C to Ca2+-activated chloride channels | journal = Sci Signal | volume = 1 | issue = 4 | pages = pe5 | year = 2008 | pmid = 18272466 | doi = 10.1126/stke.14pe5 | s2cid = 36710246 }}{{cite journal |vauthors=Chamberlain PP, Qian X, Stiles AR, Cho J, Jones DH, Lesley SA, Grabau EA, Shears SB, Spraggon G | title = Integration of inositol phosphate signaling pathways via human ITPK1 | journal = J. Biol. Chem. | volume = 282 | issue = 38 | pages = 28117–25 |date=September 2007 | pmid = 17616525 | pmc = 2244811 | doi = 10.1074/jbc.M703121200 | doi-access = free }}

References

{{cite journal |vauthors=Wilson MP, Sun Y, Cao L, Majerus PW |title=Inositol 1,3,4-trisphosphate 5/6-kinase is a protein kinase that phosphorylates the transcription factors c-Jun and ATF-2. |journal=J. Biol. Chem. |volume=276 |issue= 44 |pages= 40998–1004 |year= 2001 |pmid= 11533064 |doi= 10.1074/jbc.M106605200 |doi-access=free }}
{{cite journal |vauthors=Ho MW, Yang X, Carew MA, etal |title=Regulation of Ins(3,4,5,6)P(4) signaling by a reversible kinase/phosphatase. |journal=Curr. Biol. |volume=12 |issue= 6 |pages= 477–82 |year= 2002 |pmid= 11909533 |doi=10.1016/S0960-9822(02)00713-3 |doi-access=free }}
{{cite journal |vauthors=Sun Y, Wilson MP, Majerus PW |title=Inositol 1,3,4-trisphosphate 5/6-kinase associates with the COP9 signalosome by binding to CSN1. |journal=J. Biol. Chem. |volume=277 |issue= 48 |pages= 45759–64 |year= 2003 |pmid= 12324474 |doi= 10.1074/jbc.M208709200 |doi-access= free }}
{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
{{cite journal |vauthors=Sun Y, Mochizuki Y, Majerus PW |title=Inositol 1,3,4-trisphosphate 5/6-kinase inhibits tumor necrosis factor-induced apoptosis. |journal=J. Biol. Chem. |volume=278 |issue= 44 |pages= 43645–53 |year= 2003 |pmid= 12925536 |doi= 10.1074/jbc.M300674200 |doi-access= free }}
{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
{{cite journal |vauthors=Qian X, Mitchell J, Wei SJ, etal |title=The Ins(1,3,4)P3 5/6-kinase/Ins(3,4,5,6)P4 1-kinase is not a protein kinase. |journal=Biochem. J. |volume=389 |issue= Pt 2 |pages= 389–95 |year= 2005 |pmid= 15762844 |doi= 10.1042/BJ20050297 | pmc=1175116 }}
{{cite journal |vauthors=Miller GJ, Wilson MP, Majerus PW, Hurley JH |title=Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase. |journal=Mol. Cell |volume=18 |issue= 2 |pages= 201–12 |year= 2005 |pmid= 15837423 |doi= 10.1016/j.molcel.2005.03.016 |doi-access= free }}
{{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }}

ITPK1

References

Further reading