ITPR3

ITP3 channels serve an important role in the taste transduction pathway of sweet, bitter and umami tastes the gustatory system. ITP3 channels allow the flow of Calcium out of the endoplasmic reticulum in response to IP3. Calcium cations result in the activation of TRPM5 which leads to a depolarisation generating potential and an action potential.{{cite journal |vauthors=Chaudhari N, Roper SD | title = The cell biology of taste | journal = J. Cell Biol. | volume = 190 | issue = 3 | pages = 285–96 |date=August 2010 | pmid = 20696704 | pmc = 2922655 | doi = 10.1083/jcb.201003144 }}

• Inositol trisphosphate receptor

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• {{cite journal |vauthors=Kline CF, Cunha SR, Lowe JS, etal |title=Revisiting ankyrin-InsP3 receptor interactions: ankyrin-B associates with the cytoplasmic N-terminus of the InsP3 receptor |journal=J. Cell. Biochem. |volume=104 |issue= 4 |pages= 1244–53 |year= 2008 |pmid= 18275062 |doi= 10.1002/jcb.21704 |pmc=2858327 }}
• {{cite journal |vauthors=Oishi T, Iida A, Otsubo S, etal |title=A functional SNP in the NKX2.5-binding site of ITPR3 promoter is associated with susceptibility to systemic lupus erythematosus in Japanese population |journal=J. Hum. Genet. |volume=53 |issue= 2 |pages= 151–62 |year= 2008 |pmid= 18219441 |doi= 10.1007/s10038-007-0233-3 |doi-access= free }}
• {{cite journal |vauthors=Hirose M, Stuyvers B, Dun W, etal |title=Wide long lasting perinuclear Ca²⁺ release events generated by an interaction between ryanodine and IP3 receptors in canine Purkinje cells |journal=J. Mol. Cell. Cardiol. |volume=45 |issue= 2 |pages= 176–84 |year= 2008 |pmid= 18586264 |doi= 10.1016/j.yjmcc.2008.05.008 |pmc=2566512 }}
• {{cite journal |vauthors=Miyachi K, Iwai M, Asada K, etal |title=Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases |journal=Mod Rheumatol |volume=17 |issue= 2 |pages= 137–43 |year= 2007 |pmid= 17437169 |doi= 10.1007/s10165-006-0555-6 |s2cid=36516047 }}
• {{cite journal |vauthors=Tang TS, Guo C, Wang H, etal |title=Neuroprotective effects of inositol 1,4,5-trisphosphate receptor C-terminal fragment in a Huntington's disease mouse model |journal=J. Neurosci. |volume=29 |issue= 5 |pages= 1257–66 |year= 2009 |pmid= 19193873 |doi= 10.1523/JNEUROSCI.4411-08.2009 |pmc=2768402 }}
• {{cite journal |vauthors=Nagaleekar VK, Diehl SA, Juncadella I, etal |title=IP3 receptor-mediated Ca²⁺ release in naive CD4 T cells dictates their cytokine program |journal=J. Immunol. |volume=181 |issue= 12 |pages= 8315–22 |year= 2008 |pmid= 19050248 |doi= 10.4049/jimmunol.181.12.8315|pmc=2756541 }}
• {{cite journal |vauthors=Bandyopadhyay BC, Swaim WD, Liu X, etal |title=Apical localization of a functional TRPC3/TRPC6-Ca²⁺-signaling complex in polarized epithelial cells. Role in apical Ca²⁺ influx |journal=J. Biol. Chem. |volume=280 |issue= 13 |pages= 12908–16 |year= 2005 |pmid= 15623527 |doi= 10.1074/jbc.M410013200 |doi-access= free }}
• {{cite journal |vauthors=Kasri NN, Holmes AM, Bultynck G, etal |title=Regulation of InsP3 receptor activity by neuronal Ca²⁺-binding proteins |journal=EMBO J. |volume=23 |issue= 2 |pages= 312–21 |year= 2004 |pmid= 14685260 |doi= 10.1038/sj.emboj.7600037 |pmc=1271747 }}
• {{cite journal |vauthors=Hattori M, Suzuki AZ, Higo T, etal |title=Distinct roles of inositol 1,4,5-trisphosphate receptor types 1 and 3 in Ca²⁺ signaling |journal=J. Biol. Chem. |volume=279 |issue= 12 |pages= 11967–75 |year= 2004 |pmid= 14707143 |doi= 10.1074/jbc.M311456200 |doi-access= free }}
• {{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |doi-access=free }}
• {{cite journal |vauthors=Roach JC, Deutsch K, Li S, etal |title=Genetic mapping at 3-kilobase resolution reveals inositol 1,4,5-triphosphate receptor 3 as a risk factor for type 1 diabetes in Sweden |journal=Am. J. Hum. Genet. |volume=79 |issue= 4 |pages= 614–27 |year= 2006 |pmid= 16960798 |doi= 10.1086/507876 |pmc=1592562 }}
• {{cite journal |vauthors=Tojyo Y, Morita T, Nezu A, Tanimura A |title=The clustering of inositol 1,4,5-trisphosphate (IP(3)) receptors is triggered by IP(3) binding and facilitated by depletion of the Ca²⁺ store |journal=J. Pharmacol. Sci. |volume=107 |issue= 2 |pages= 138–50 |year= 2008 |pmid= 18544901 |doi=10.1254/jphs.08021FP |doi-access=free }}
• {{cite journal |vauthors=Singleton PA, Bourguignon LY |title=CD44 interaction with ankyrin and IP3 receptor in lipid rafts promotes hyaluronan-mediated Ca²⁺ signaling leading to nitric oxide production and endothelial cell adhesion and proliferation |journal=Exp. Cell Res. |volume=295 |issue= 1 |pages= 102–18 |year= 2004 |pmid= 15051494 |doi= 10.1016/j.yexcr.2003.12.025 }}
• {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
• {{cite journal |author=Ogasawara H |title=The calcium kinetics and inositol trisphosphate receptor properties shape the asymmetric timing window of coincidence detection |journal=J. Neurosci. |volume=28 |issue= 17 |pages= 4293–4 |year= 2008 |pmid= 18434505 |doi= 10.1523/JNEUROSCI.0644-08.2008 |pmc=6670947 |doi-access= free }}
• {{cite journal |vauthors=Qu HQ, Marchand L, Szymborski A, etal |title=The association between type 1 diabetes and the ITPR3 gene polymorphism due to linkage disequilibrium with HLA class II |journal=Genes Immun. |volume=9 |issue= 3 |pages= 264–6 |year= 2008 |pmid= 18340361 |doi= 10.1038/gene.2008.12 |doi-access= |s2cid=8563179 }}
• {{cite journal |vauthors=Wu Z, Bowen WD |title=Role of sigma-1 receptor C-terminal segment in inositol 1,4,5-trisphosphate receptor activation: constitutive enhancement of calcium signaling in MCF-7 tumor cells |journal=J. Biol. Chem. |volume=283 |issue= 42 |pages= 28198–215 |year= 2008 |pmid= 18539593 |doi= 10.1074/jbc.M802099200 |pmc=2661391 |doi-access=free }}
• {{cite journal |vauthors=Martínez-Gámez A, Dent MA |title=Expression of IP3 receptor isoforms at the nodes of Ranvier in rat sciatic nerve |journal=NeuroReport |volume=18 |issue= 5 |pages= 447–50 |year= 2007 |pmid= 17496801 |doi= 10.1097/WNR.0b013e32805868a6 |s2cid=28136973 }}
• {{cite journal |vauthors=Garcia-Elias A, Lorenzo IM, Vicente R, Valverde MA |title=IP3 receptor binds to and sensitizes TRPV4 channel to osmotic stimuli via a calmodulin-binding site |journal=J. Biol. Chem. |volume=283 |issue= 46 |pages= 31284–8 |year= 2008 |pmid= 18826956 |doi= 10.1074/jbc.C800184200 |doi-access= free }}
• {{cite journal |vauthors=Sundivakkam PC, Kwiatek AM, Sharma TT, etal |title=Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca²⁺ store release-induced Ca²⁺ entry in endothelial cells |journal=Am. J. Physiol., Cell Physiol. |volume=296 |issue= 3 |pages= C403–13 |year= 2009 |pmid= 19052258 |doi= 10.1152/ajpcell.00470.2008 |pmc=2660268 }}

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• {{MeshName|ITPR3+protein,+human}}

{{Ion channels|g1}}

Category:Ion channels

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